In an attempt to synthesize new chemical entities with promising biological activity, a set of six novel pyrimidinedione analogues 6(a-f) was prepared. The compound 4 was coupled with different amines by using HBTU as a coupling reagent. The derivatives were characterized by ¹HNMR,¹³CNMR and HRMS. The analogues were evaluated for their antibacterial and antioxidant activity. The DPPH and ABTS methods were used to test the antioxidant activity of the moieties. Among the six pyrimidinedione analogues, 6b, 6d, and 6f exhibited significant antioxidant effects. The paper disc diffusion method was adopted to evaluate the antibacterial activity of the samples. The analogues 6b, 6c and 6e exhibited potency against gram-negative and gram-positive pathogens. Further, to evaluate the binding abilities of the analogues to the protein active sites, molecular docking studies were performed. The results of the docking studies were found to be consistent with the antibacterial potential of the analogues. The efficacy of these analogues provides insight into their use as novel antioxidant and antibacterial agents.

Titled compounds 3a-j were synthesized by the reaction of 4-benzyloxyindole-2-carboxylic acid (1) with different amines 2a-j in the presence of NMM and Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium. The in vitro antibacterial activities of compounds (3a-j) against the strains of bacteria Pseudomonas aeruginosa and Staphylococcus aureus revealed that compounds 3a, 3b, 3c, 3h, 3i, and 3j have good potency, whereas compounds 3d and 3e have activity only against S. aureus. Molecular docking studies were carried out by choosing FabH protein from the PDB, which gave good binding free energy ranging from -10.507 to -6.40. The pharmacokinetic properties and toxicity of these compounds were predicted using pkCSM online tool.. KEYWORDS :Antibacterial activity, FabH transferase, Indole derivatives, Minimum inhibitory concentration, PkCSM.

The study of 1,3,4-oxadiazole derivatives has witnessed significant growth due to their versatile biological activities and therapeutic potential in medicinal chemistry. The present study reports bibliometric analysis from 2000 to 2025, focusing on a comprehensive overview of research trajectory associated with 1,3,4-oxadiazoles. The Scopus and Web of Science databases have been used in the study to collect bibliometric data. The bibliometric tools Biblioshiny and VOS viewer are used. The evolution of literature regarding oxadiazoles was presented using publication metrics, citation patterns, institutions and influential journals. Along with the mentioned metrics, trend, thematic and tree maps were also included in the study. The study enables the researchers to identify the research gap and give future directions in the area of 1,3,4-oxadiazoles.