The hemophilias are the most common X-linked inherited bleeding disorders, and if not managed properly, they can lead to chronic disease and lifelong disabilities. The hemophilias remains a hot topic in the field of hematology. This bibliometric study aimed to investigate the current status of publications on haemophilia. The goal of this study was to retrieve data from journals that were indexed in the Web of Science (WoS; Thomson Reuters, New York, NY, USA) database. Keywords related to “Hemophilia” were used. The time span was set from 1970 to 2021. Data pertaining to growth of publications, the most active countries and institutions, the most cited journals, and mapping of publications and keywords were analyzed. Retrieved data were analyzed to present various bibliometric indicators while maps were visualized using the VOS viewer technique. The Hirsch (H) index and the impact factor (IF) of the publishing journal were used as indicators of impact of publications. A total of 7.736 articles were retrieved with an average of 22.06 and total of 170.624 citations. H index was found as 149. Study searches the publications in the period between 1970 and 2020 first article was in the year 1970. The leading country on journal number is the United States of America (USA) with (n=2474; 31.98%), followed by England (11.69%), Germany (9.76%), Italy (8.59%), Canada (6.81%), France (6.67%). Most of the retrieved articles were from research areas of Hematology (n=4706; 60.83%), Cardiovascular System/Cardiology (11.46%), General Internal Medicine (10.12%), Pediatrics (4.52%), Genetics Heredity (n4.25%). The number of publications from the development countries should be increased and research on hemophilia should be supported. The landscape of this illness is changing continuously, and bibliometric studies like the one presented are a useful tool for highlighting developments inside this field.

Thalassemia minor carriage is one of the most common causes of anemia in Mediterranean countries. This study aimed to investigate the publications in scientific journals on thalassemia minor, which is an important health problem, especially in Mediterranean countries. The goal of this study was to retrieve data from journals that were indexed in the Web of Science (WoS; Thomson Reuters, New York, NY, USA) database. The WOS Core Collection was used to retrieve comprehensive bibliometric data. Keywords related to "beta-thalassemia carrier," or "beta-thalassemia trait," thalassemia minor" or "heterozygous beta-thalassemia" were used in a search query in the WOS search engine. The time frame was specified since 10 March 2022. The analysis included information on the increase of publications, the most active countries and institutions, the most cited journals, and the mapping of publications and keywords. A total of 8618 publications were retrieved. The first article was published in 1970, and the period between 1970 and 2021 was searched. The maximum number of publications was published in the year 2021. The number of publications had increased since 2009. Most of the publications were articles (61.696 %). The publications were from more than 100 disciplines and most of them were from Hematology (49.176%). The publications were from 274 different countries. Most of the publications were from the USA, Italy, and Greece. The USA is at the top of the list in the number of publications. But with active funding and support from the governments especially the Mediterranean countries, which have a higher prevalence of thalassemia minor, the productivity of scientific research should be increased.

Aim: Inflammatory bowel disease (IBD) is a chronic disease with systemic implications, including cardiovascular effects. The aim of this study was to investigate the impact of IBD on right ventricular (RV) function and pulmonary hemodynamics, focusing on the relationship between pulmonary pulse transit time (pPTT) and other echocardiographic markers. Material and Methods: Fifty IBD patients and 50 matched healthy controls underwent echocardiographic evaluation to assess RV function, including parameters such as RV myocardial performance index (RVMPI), RV ejection fraction (RV EF) and tricuspid annular plane systolic excursion (TAPSE). Pulmonary hemodynamics were assessed by pPTT and pulmonary arterial stiffness (PAS). Statistical analyses explored the associations between IBD and these echocardiographic parameters. Results: No differences in systolic pulmonary artery pressure (sPAP) or TAPSE were observed between the groups. PAS was increased and pPTT was shortened in IBD patients compared to controls. pPTT correlated with PAS, IBD duration, RV EF, RV fractional area change (RVFAC), TAPSE, tricuspid S', RVMPI and C-reactive protein (CRP). pPTT was an independent predictor of PAS (p < 0.001). Conclusion: IBD patients show impaired RV function and increased pulmonary stiffness. pPTT may serve as a practical marker for early detection of pulmonary vascular changes in IBD, replacing PAS for hemodynamic assessment.

Giriş: Mide kanseri, dünya çapında en sık teşhis edilen beşinci malignite olup, tanı anında sıklıkla ileri evrede olması nedeniyle mortalitesi yüksektir. Bu çalışmada merkezimizde takip ve tedavi edilen mide kanseri hastalarında genel sağkalım (GS) sonuçlarını ve sağ kalım ile ilişkili prognostik faktörleri araştırmayı amaçladık. Yöntemler: Ocak 2013 - Eylül 2020 yılları arasında takip edilen mide adenokanseri olan 200 hastanın verileri retrospektif olarak değerlendirilip kaydedildi. Bulgular: Çalışmaya alınan hastaların erkek/kadın oranı 2.3:1 ve ortanca yaş 63,83± 11,88 yıl olarak tespit edildi. Hastaların %7'sinin evre 1, %12,5'inin evre 2, %23'ünün evre 3 ve %55,5'inin evre 4 olduğu izlendi. Yaş (≤60 ve >60), cinsiyet, tümör histolojik alt tipi, tümör boyutu (≤) 5 ve >5 cm), tümör yerleşimi (antrum, korpus, kardia), TNM evresi (1, 2, 3 veya 4), lenfovasküler invazyon (var veya yok), perinöral invazyon (var veya yok), operasyon öyküsü (opere, inoperabl), cerrahi sınır durumu (pozitif veya negatif), progresyon varlığı (var veya yok) ve metastaz varlığı (var veya yok) GS'yi etkileyebilecek prognostik faktörler olarak araştırıldı. Faktörlerin tek değişkenli analizine göre; erken TNM evresi, metastaz yokluğu, adjuvan KRT ve FUFA rejimi almak, artmış GS ile ilişkiliydi (p=0.001). Sadece erken T evresi [OR: 1.38 (%95 CI, 1.046 1.822)], (p=0.023) ve adjuvan KT almak [OR: 4.5 (%95 CI, 1.554-13.046)], (p=0.006) prognostik faktörlerin çok değişkenli lojistik regresyon analizinde artan GS ile ilişkiliydi. Sonuç: Mide adenokarsinomlu hastalarda TNM evresi, adjuvan KRT, kemoterapi rejimi ve küratif cerrahi rezeksiyon GS'yi önemli ölçüde etkiledi.

Background/Objectives: Hashimoto’s thyroiditis (HT) is associated with autoimmune thyroid inflammation, but its systemic inflammatory, immunonutritional, and atherogenic lipid profile across thyroid functional groups remains insufficiently characterized. This study aimed to evaluate routinely available inflammatory, immunonutritional, and atherogenic indices across the HT spectrum and to examine their relationships with thyroid function and autoimmunity. Methods: This retrospective study included newly diagnosed, untreated adult patients with HT and healthy controls without documented comorbidities. After exclusions and propensity score matching for age, sex, and body mass index, 148 patients with HT and 74 controls were analyzed. Patients with HT were classified as euthyroid HT (EH, n = 62), subclinical hypothyroidism (SCH, n = 47), or overt hypothyroidism (OH, n = 39). A total of 44 demographic, thyroid-related, hematologic, biochemical, lipid, inflammatory, immunonutritional, and atherogenic variables were evaluated. Elastic Net–penalized logistic regression, multivariable logistic regression, correlation analysis, and receiver operating characteristic curve analysis were performed. Results: HT was associated with a distinct systemic profile characterized by higher inflammatory and atherogenic indices and alterations in immunonutritional indices. Across the control, EH, SCH, and OH groups, systemic inflammation response index (SIRI; 0.5 vs. 0.8 vs. 1.0 vs. 1.4, p < 0.001) and atherogenic index of plasma (AIP; 0.1 vs. 0.3 vs. 0.5 vs. 0.8, p < 0.001) showed an ascending pattern, whereas prognostic nutritional index (PNI; 56.0 ± 3.2 vs. 50.2 ± 6.0 vs. 46.8 ± 5.5 vs. 40.6 ± 7.0, p < 0.001) showed a descending pattern. In multivariable models, SIRI and AIP were independently associated with EH compared with controls, whereas SIRI, AIP, and PNI were independently associated with SCH compared with EH and with OH compared with SCH. SIRI and AIP showed strong positive correlations with thyroid-stimulating hormone and negative correlations with free thyroxine, while PNI showed the opposite pattern. These indices also differed significantly according to anti-thyroid peroxidase and anti-thyroglobulin antibody status. Conclusions: Distinct inflammatory, immunonutritional, and atherogenic lipid profiles were observed across HT groups. SIRI and AIP may reflect systemic alterations even in EH, whereas lower PNI may reflect immunonutritional alterations associated with SCH or OH.