Background: Various symptoms have been associated with COVID-19, but little is known about the impacts of COVID-19 on the sensory system, risk factors, and the duration of symptoms. This study assesses olfactory, gustatory, hearing, and vestibular systems after COVID-19. Methods: This cross-sectional, single-center study involved 50 patients one to six months after COVID-19 and reports their patient records and the extent, onset, and duration of olfactory, gustatory, hearing, and balance disorders using questionnaires during and after COVID-19. Sensory symptoms were objectively studied using the following clinical tests after COVID-19 Sniffin’ Sticks, taste tests, tone/speech audiometry, and video head impulse test. Results: Post-COVID-19-patients were suffering from olfactory and gustatory impairment for up to six months. According to the Dizziness Handicap Inventory, balance disorders were less noticed: Overall, about 40% of the patients during COVID-19 and nearly all patients recovered within six months. After COVID-19, clinical tests revealed that 75% were suffering from hyposomnia/anosmia, and 20% of all patients reported mild hypogeusia for up to six months. Vestibular disorders and hearing impairment rarely/did not occur. Females were significantly more affected by sensory impairments than males. Conclusions: COVID-19 particularly caused olfactory and gustatory impairment; balance disorders were present too; vestibular and auditory symptoms were negligible.

Salivary duct carcinomas (SDC) of the parotid gland are rarely occurring highly malignant tumors. A 65-year-old man presented with a preauricular mass. After surgical treatment and histologic examination, the findings were interpreted as a squamous cell carcinoma (SCC) metastasis of the parotid gland deriving from a cancer of unknown primary DD primary SCC of the parotid gland. Adjuvant platinum-based radiochemotherapy was administered in domo. However, re-staging revealed multiple size-progressive pulmonary round lesions. After resection and histological examination of a pulmonary mass and in synopsis with the primary tumor, the initial diagnosis of SCC was revised to SDC of the parotid gland. With positive HER-2 status, off-label trastuzumab/docetaxel was initiated in an individual healing attempt, during which the pulmonary metastases showed clear progression. Consequently, the patient received immunotherapy with nivolumab according to his negative PD-L1 status. After 57 cycles of nivolumab, the patient presents with partial remission and in good condition. We report, for the first time, a robust response of metastatic SDC to checkpoint inhibition with nivolumab without additional radiotherapy.

Introduction: Auricular keloids may be associated with social stigma and impair patients’ quality of life (QoL) significantly. Little is known about the effect of different therapeutic concepts on the patient’s QoL. This study aims to investigate the QoL in patients with auricular keloids undergoing a specific multimodal therapeutic regimen. Materials and Methods: Patients suffering from auricular keloids were treated by a multimodal treatment comprising surgical excision, intralesional triamcinolone acetonide, and subsequent application of customized magnetic pressure splints. A prospective assessment of QoL was conducted using the validated Keloid Intervention Benefit Inventory-21 questionnaire at three time points. Results: In total, 22 auricular keloids were included in our study. All patients completed a comprehensive 1-year follow-up assessment, with an average follow-up duration of 29 months post-surgery. Quantitative analysis of QoL metrics demonstrated significant improvement of QoL at the three times of measurement ( P < .0001). Significant results were also found for the subcategories general health, physical health, social interaction, and self-esteem. Conclusion: This study underscores the necessity of assessment of QoL in keloid treatment. Our findings highlight the advantages of multimodal treatment in enhancing patients’ QoL throughout the treatment period and managing auricular keloids with low recurrence. Trial Registration: The study was registered at the German Clinical Trials Register (Register ID: DRKS00016348, https://drks.de/search/en/trial/DRKS00016348 ).

Introduction As accurate as possible planning of operating times is an important topic with potential for conflicts. High capacity utilisation of OR is essential for economic efficiency. At the same time working hours (also of other specific fields and occupational groups) must be respected. To detect sources of error, objective (obj.) and by surgeons estimated times were compared. Method In a retrospective analysis the duration of 1809 operations (22 different types) by 31 different surgeons (12 specialist (S), 19 residents (R)) of the ENT department at Mannheim university medical centre were compared. By questionnaires estimated incision to suture, preparation and postprocessing times from 10 S and 17 R were compared to the obj. times. Both comparisons were analysed by Mann-Whitney-U-test. Results Comparison of obj. times from S and R showed significant differences for times of surgical action in 6 out of 15 types of surgery (p<0,001). By S estimated postprocessing times deviate from obj. times in 2 out of 22 types of surgery (p<0,05). By R estimated postprocessing times deviate in 7 out of 15 types (p<0,05). S misjudge incision to suture times in 7 out of 22 types of surgery (p<0,05), R in 3 out of 15 (p<0,05). By S estimate preparation times deviate significant from obj. times in 16 out of 22 types of surgery (p<0,05), by R estimate preparation times in 7 out of 15 (p = 0,00). Discussion For the estimation of operating times the surgeon`s routine for the planned surgery must be considered. S underrate preparation and postprocessing and overrate incision to suture times. R underestimate all these times. Preparation and postprocessing times must be considered in the planning of OR-times and in ideal circumstances be determined together with the operating room assistants. Poster-PDF A-1763.PDF Publication Date: 10 June 2020 (online) © . © Georg Thieme Verlag KG Stuttgart · New York

Introduction: Measurement of health-related quality of life (QoL) is a firmly established method for evaluating therapeutic procedures. Studies have demonstrated positive effects of passive music interventions. To date, however, no standardized approach to music therapy interventions after head and neck surgery has been developed. Furthermore, the effects of such interventions in the immediate postoperative phase following surgery in head and neck region have yet to be adequately investigated. Methods: Patients undergoing tonsillectomy were consecutively included in a prospective randomized study. The intervention group received passive music therapy (60 minutes/day). QoL was recorded using the Glasgow Benefit Inventory (GBI) and Brief Pain Inventory (BPI) at 3 fixed time points after operation. In addition, the participants filled out a pain diary throughout the observation period using a Visual Analog Scale. Results: Study sample comprised 31 patients. Fifteen patients (6 women and 9 men) were included in the intervention group and 16 (6 women and 10 men) in the control group. Participants’ average ages were 28 years (intervention group) and 39 years (control group). Significant differences in QoL emerged 5 and 14 days after surgery ( P = .049 and <.01). In addition, the BPI results differed significantly at time point 3 ( P < .01). Significant differences were observed in the pain diary from day 8 after surgery. Discussion/Conclusion: Complementary music interventions may improve QoL as well as patients’ pain perception. Owing to its ubiquitous availability and cost-effectiveness, passive music interventions with their measurable positive benefits may be easily implemented into clinical routine.

Einleitung Die möglichst genaue Planung von Op-Zeiten ist wichtig und oft konfliktbehaftet. Die Auslastung von Op-Sälen ist essentiell für die Wirtschaftlichkeit. Gleichzeitig muss die Einhaltung von Arbeitszeiten (auch anderer Fachdisziplinen/Berufsgruppen) berücksichtigt werden. Um Fehlerquellen aufzudecken, wurden durch Chirurgen geschätzte mit objektiv (obj.) Zeiten verglichen. Methoden In einer retrospektiven Analyse in der HNO-Universitätsklinik Mannheim wurden 1809 Ops (22 Op-Arten) durch 31 Operateure (12 Fach- (FÄ), 19 Assistenzärzte (AÄ)) hinsichtlich ihrer Dauer verglichen. Die zusätzlich in Fragebögen geschätzte Schnitt-Naht-, Vorbereitungs- und Nachbereitungszeit von 10 FÄ und 17 AÄ wurden mit den obj. Zeiten verglichen. Beide Vergleiche wurden mit dem Mann-Whitney-U-Test hinsichtlich ihrer statistischen Signifikanz geprüft. Ergebnisse Der Vergleich der obj. Zeiten von FÄ und AÄ zeigt signifikante Unterschiede in der obj. Zeit der chirurg. Maßnahmen für 6 von 15 Op-Arten (p<0,001). Die durch FÄ geschätzte Nachbereitungszeit wich bei 2 von 22 Op-Arten von der obj. Zeit ab (p<0,05), die durch AÄ geschätzte Zeit bei 7 von 15 Op-Arten (p<0,05). In Schnitt- Naht- Zeit verschätzten sich FÄ bei 7 von 22 (p<0,05), AÄ bei 3 von 15 (p<0,05) Op-Arten. Die durch FÄ geschätzte Vorbereitungszeit wich bei 16 von 22 Op-Arten signifikant von der obj. Zeit ab (p<0,05) bei AÄ bei 7 von 15 (p = 0,00). Diskussion: Für die die Op-Zeiteneinschätzung muss die Routine des Chirurgen für den entsprechenden Eingriff berücksichtigt werden. Vor- und Nachbereitungszeiten wurden durch FÄ unter-, Schnitt-Naht-Zeiten überschätzt. AÄ unterschätzten alle Zeiten. Vor- und Nachbereitungszeiten müssen idealerweise gemeinsam mit dem Pflegepersonal bestimmt und in der Op-Planung berücksichtigt werden. Publication Date: 10 June 2020 (online) © . © Georg Thieme Verlag KG Stuttgart · New York