The use of hydraulic models for carrying out flood simulations is a common practice globally. The current study used HEC-RAS (2D) in order to simulate different flood scenarios on the River Yesil (Ishim). Comparison of different mesh sizes (25, 50 and 75 m) indicated no significant difference in model performance. However, a significant difference was observed in simulation time. In addition, the inclusion of breaklines showed that there was a slight improvement in model performance and a shortening of the simulation time. Sensitivity analysis and the consequent manual calibration of sensitive parameters resulted in a slight improvement (an increase in the model accuracy from 58.4% for uncalibrated to 59.7% for calibrated). Following the simulations inundation maps for 10-, 20- and 100-year flood events were obtained. Hazard classification of the flood extents generated indicated that the settlements of Zhibek Zholy and Arnasay were flooded in all the simulated events. Volgodonovka village experienced flooding when a 100-year flood event was simulated. On the other hand, settlement No. 42 did not experience any flooding in any of the scenarios. The model results also demonstrate that the Counter-Regulator was not overtopped in the event of the 100-year hydrograph.