Although millions of people have been infected by Helicobacter pylori (H. pylori), only a small proportion of infected individuals will develop adverse outcomes, ranging from chronic gastritis to gastric cancer. Advanced development of the disease has been well-linked with chronic inflammation, which is significantly impacted by the adaptive and humoral immunity response. From the perspective of cellular immunity, this review aims to clarify the intricate axis between IL-17, IL-21, and IL-23 in H. pylori-related diseases and the pathogenesis of inflammatory gastrointestinal diseases. CD4⁺ helper T (Th)-17 cells, with the hallmark pleiotropic cytokine IL-17, can affect antimicrobial activity and the pathogenic immune response in the gut environment. These circumstances cannot be separated, as the existence of affiliated cytokines, including IL-21 and IL-23, help maintain Th17 and accommodate humoral immune cells. Comprehensive understanding of the dynamic interaction between molecular host responses in H. pylori-related diseases and the inflammation process may facilitate further development of immune-based therapy.

Many attempts have been made to improve human body resistance towards infection. These attempts were exemplified by promotion of hygiene and the use of antiseptic ingredients, pharmaceutical compounds, and vaccines. To prove an aspect which intentionally less explored was attempt to boosting the host immune responses by creating a psychological balance, which was important aspect of psychological well-being. These article reviews searched and compiled using database Google Scholar, from 1995 to latest. Search keywords were: immune response, psychological well-being, psychological ill-being. Based on literature our findings showed that psychological well-being was proven could increase human body immune response. The evidenced were by improvements of several indicators in saliva, blood and plasma. In other way, psychological ill-being was associated with decreased immune responses. Numerous studies compiled and discussed in review also suggested that improving immune response through psychological well-being could increase living comfort. The psychological well-being could improve the human body immune responses, enhance resistance towards diseases (including infectious diseases), and create a spiritually and physically more prosperous life.

Poor oral health has been reported to correlate to the body mass index (BMI) of the overweight and the obesity groups. These has yet widely studied in Indonesia. The aim of this study was to analysed the oral health, socioeconomy factors (FSE) and the BMI in the seemingly healthy university students in Kediri aged 18-21 years old. This cross-sectional study was conducted amongst male and female students of IIKBW, Kediri, Indonesia (n=150). We analysed their BMI from the body weight and height (kg/m2). Their oral health was determined by the DMFT index (decayed missing filled teeth index), the stimulated salivary flow rate (SSFR) and the gingival index (GI). FSE studied include father’s highest education and monthly income, tooth brushing frequency in a day and dental floss habitual use. Data was analysed using SPSS 17 with level of significance of p 0.05). There were 41.8% of males and 57.8% of females have “bad” score of DMFT and 98.6% of males and 92.1% of females have “bad” score of GI; 4.1% of males and 2.6% of females have low score of SSFR. Although we found no significant differences in the BMI and oral health parameters between genders, in the seemingly healthy young adults oral health hygiene could be compromised as found in the current study indicated by bad scores of DMFT, SSFR or GI. Here we found that either BMI or FSE was not significantly correlated to any of oral health parameters measured in the current study.

Context: Dry cupping and acupuncture are complementary treatments that can be used to decrease low back pain (LBP) in postpartum mothers. Aims: To analyze the pain intensity after each treatment measured by visual analog scale (VAS) in postpartum mothers with LBP. Methods: Articles for this systematic review and meta-analysis were retrieved from Web of Science, Science Direct, PubMed, Google Scholar, and Scopus (10/1/2013-12/31/2022), adjusted for inclusion and exclusion criteria, and filtered according to PRISMA guidelines, and the meta-analysis was using Review Manager 5.4. The Newcastle-Ottawa scale was selected to ascertain the quality of each included paper. Results: Four randomized controlled- trials (RCTs) with 157 patients were included. VAS scores from these studies showed that after acupuncture and dry cupping treatment, the VAS scores were significantly lower in LBP-postpartum mothers than in controls (SMD IV, Random 95%: 1.69 [95% I2 = 83%; p = 0.00001]) and (SMD IV, Random, 95%: 2.06 [95% I2 = 63 %; p = 0.0001]), respectively. The LBP among these postpartum mothers can be triggered by perinatal stress, postpartum baby blues, and other back pain-related morbidities. Conclusions: Both acupuncture and dry cupping effectively reduced LBP in postpartum mothers. However, dry cupping showed a higher impact and was arguably more beneficial due to this method's non-invasiveness. Furthermore, acupuncture and dry cupping are considered safe treatments after giving birth because they do not interfere with breast milk production.

J. Pharm. Pharmacogn. Res., vol. 12, no. 2, pp. 218-230, Mar-Apr 2024. DOI: https://doi.org/10.56499/jppres23.1741_12.2.218 Review Atorvastatin versus tetrahydrolipstatin in male patients with dyslipidemia: A systematic review and meta-analysis [Atorvastatina frente a tetrahidrolipstatina en pacientes varones con dislipidemia: Una revisión sistemática y meta-análisis] Nur Aini Hasan1,3, Viskasari Pintoko Kalanjati2*, Kusuma Eko Purwantari2, Abdurachman Abdurachman2, Muhammad Miftahussurur4,5 Atorvastatin versus tetrahydrolipstatin in male patients with dyslipidemia: A systematic review and meta-analysis