Pharmacists working in the multidisciplinary gynaecological oncology pre-admission clinic (PAC) are involved in the perioperative assessment of patients for a comprehensive medication history and information provision regarding withholding of medications before surgery. To evaluate the current services provided by pharmacists to multidisciplinary staff and patients attending the PAC. A staff and a patient feedback survey on the value and impact of PAC pharmacy services were distributed within the PAC. The impact of the PAC pharmacist was also assessed by analysing pharmacist interventions and key performance indicators documented. Fifteen staff responses were recorded, 5 nursing staff, 2 midwives and 8 anaesthetists. Eighty-seven percent (n = 13) strongly agreed or agreed that pharmacists at PAC help reduce medication errors on admission. Staff strongly agreed 73% (n = 11) pharmacists obtain a more accurate medication history. Staff reported benefits in having a pharmacist at the clinic to discuss medication related questions with 87% (n = 13) strongly agreeing or agreeing with the statement. A staff overall satisfaction rating of 4.87 out of 5 was recorded. In the patient survey, respondents (n = 6) gave a 4.83 out of 5 rating in confidence in making changes to their medication and their overall satisfaction with the service provided. In reviewing data from January to June 2022, the number of patients seen by the pharmacist were 178 of 681 patients (26.1%) who attended the clinic. The most common medications involved in the pharmacist intervention include those that were advised to be withheld and those that required other changes to therapy prior to their procedure. The role of a PAC pharmacist can be greatly appreciated by the multidisciplinary team and patients. Pharmacist interventions and key performance indicators have demonstrated the important activities of clinical pharmacy services in the PAC in optimising patient care in medication management.

(1) Background: Medication-related problems (MRPs) are a significant burden on health care systems. Pharmacists play an important role in preventing and reducing MRPs through clinical review, education, and policy governance. This study analyzed pharmacist interventions within a 92-bed neonatal clinical care unit to better understand MRPs and guide targeted medication safety initiatives. (2) Methods: All pharmacist interventions documented in REDCap^® between 1 July 2022 and 30 June 2025 were analyzed identifying MRP incidence, types, and acceptability following interventions. (3) Results: A total of 873 pharmacist interventions were recorded during the study period. The most common MRPs were related to dosing errors (320/873, 36.7%), compliance with hospital policy (152/873, 17.4%), no indication apparent (106/873, 12.1%), drug interactions (66/873, 7.6%), and inadequate laboratory monitoring (40/873, 4.6%). Of these, 545/873, 62.4% were accepted by prescribers, while 228/873, 26.1% had unknown outcomes at the time of data entry. 343/873, 39.3% of interventions documented were from the Neonatal Intensive Care Unit, involving medications such as gentamicin (n = 46/343, 13.4%), benzylpenicillin (n = 37/343, 10.8%), caffeine (n = 34/343, 9.9%), parenteral nutrition (n = 23/343, 6.7%), and morphine (n = 16/343, 4.7%) and meropenem (n = 16/343, 4.7%)). (4) Conclusions: Regular analysis of pharmacist interventions provides valuable insights into local MRP trends and highlights opportunities for quality improvement and education.

Total parenteral nutrition (TPN) is a nutritional therapy in children when oral or enteral feeding is not possible, fails to meet nutritional requirements or is contraindicated due to underlying clinical conditions. There are many cases where children who are given one or more than one intravenous medication also need TPN. In order to minimise vein access, these medications are commonly administered via a Y-site IV connection where they admix with TPN, implying a need for compatibility studies before admixing the medication into the nutritional fluid. In this study, previously developed and validated HPTLC methods were verified for their suitability to evaluate the concentrations of three commonly used medications in neonatal intensive care units (NICUs), namely caffeine citrate, ibuprofen arginine, and midazolam hydrochloride. Silica gel 60 F254 HPTLC plates were used as the stationary phase, and acetone: toluene: chloroform (4:3:3, v/v/v), toluene: methanol: ethyl acetate: glacial acetic acid (5.5:3.2:1:0.3, v/v/v/v), and cyclohexane: toluene: diethylamine (7:1.5:1.5, v/v/v) with one drop of 25% ammonia solution were used as mobile phases. The compatibility of the three drugs in their respective TPN admixtures was then assessed at various time points over a 24 h period using these HPTLC methods. Each drug admixed in TPN was directly applied onto the HPTLC plates without further sample pre-treatment. Paired Two-One-Sided Test (TOST) equivalent testing revealed that the concentrations of the selected drugs in TPN were unchanged over the monitoring period (p > 0.05), confirming chemical compatibility. These findings were in line with previous studies that concluded compatibility and reported similar R_F and LOD/LOQ values (1.95/5.90 ng/band for caffeine, 252.22/764.30 ng/band for ibuprofen and 10.82/32.78 ng/band for midazolam; R² ≥ 0.99). As no additional sample pre-treatment was required, HPTLC-based compatibility studies of drug–TPN admixtures may simplify the analytical workflow, making them a cost-effective and time-efficient approach to compatibility testing.

(1) Background: Medication related problems (MRPs) are a major burden on health care systems. Pharmacists play an important role in preventing and reducing MRPs through clinical review, education, and governance activities. This study analyzed pharmacist interventions within a 100-bed neonatal clinical care unit to better understand MRPs and guide targeted medication safety initiatives. (2) Methods: All pharmacist interventions documented in REDCap® between 01/07/2022 and 30/06/2025 were analyzed identifying MRPs incidence, types, and acceptability following interventions. (3) Results: A total of 873 pharmacist interventions were recorded during the study period. The common frequent MRPs were related to dosing errors (n=320,36.7%), compliance with hospital policy (n=152,17.4%), no indication apparent (n=106,12.1%), drug interactions (n=66,7.6%) and inadequate laboratory monitoring (n=40,4.6%). Of these, 62.4% (n=545) were accepted by prescribers, while 26.1% (n=228) had unknown outcomes at the time of data entry. The majority of interventions documented were from the Neonatal Intensive Care Unit (39.3%), involving medications such as gentamicin (n=46), benzylpenicillin (n=37), caffeine (n=34), parenteral nutrition (n=23), and morphine (n=16) and meropenem (n=16). (4) Conclusions: Regular analysis of pharmacist interventions provides valuable insights into local MRP trends and highlights opportunities for quality improvement and education.