为研究航天相关神经眼综合征（SANS）相关特征参数与微重力的相关性，以Sprague-Dawley（SD）大鼠为悬尾动物模型，构建了超长扫描深度的光学相干断层扫描（ULOCT）装置，测量大鼠眼部特征参数（角膜、前房、晶状体厚度和玻璃体腔深度及眼轴长度），以及视网膜超高分辨率（UHROCT）测量装置，测量大鼠眼底亚层结构参数（视神经层、视网膜内层、视网膜外层、脉络膜和巩膜的厚度）。结果表明大鼠悬尾1月后，眼底彩照未见明显视盘水肿等症状，但OCT结果显示大鼠眼结构发生明显改变：角膜变薄（p<0.01），眼轴缩短（p<0.05），视网膜外层变薄（p<0.01）。这些特征参数变化（尤其是眼轴明显缩短）展现了SANS亚临床前期的症状。本文为后续微观层面的SANS分子机制研究提供了宏观的动物模型以及体眼部测量新方法。

Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a theoretical method to simultaneously extract the above information using a Fourier domain optical coherence tomography (FD-OCT) system, in which no additional arrangement and prior information about the object is required other than the OCT interference spectrum. The single reflection components can be extracted from the observed spectrum by isolating the primary spikes in the sample reflectance profile, and then the refractive index and thickness can be obtained by fitting the actual and modeled values of the single reflection spectrum. In a two-layer sample example, the simulation results show that our method can reconstruct the results with high accuracy. The relative error is within 0.01%. The complexity of our approach grows linearly with the number of sample layers, making it well-adapted to multilayer situations. Our method takes into account both single and multiple reflections in multilayer samples and is therefore equally applicable to samples with high refractive index contrast.

为研究航天相关神经眼综合征（SANS）相关特征参数与微重力的相关性，以Sprague-Dawley（SD）大鼠为悬尾动物模型，构建了超长扫描深度的光学相干断层扫描（ULOCT）装置，测量大鼠眼部特征参数（角膜、前房、晶状体厚度和玻璃体腔深度及眼轴长度），以及视网膜超高分辨率（UHROCT）测量装置，测量大鼠眼底亚层结构参数（视神经层、视网膜内层、视网膜外层、脉络膜和巩膜的厚度）。结果表明大鼠悬尾1月后，眼底彩照未见明显视盘水肿等症状，但OCT结果显示大鼠眼结构发生明显改变：角膜变薄（p<0.01），眼轴缩短（p<0.05），视网膜外层变薄（p<0.01）。这些特征参数变化（尤其是眼轴明显缩短）展现了SANS亚临床前期的症状。本文为后续微观层面的SANS分子机制研究提供了宏观动物模型以及在体眼部测量新方法。

Objective: The clinical management of colorectal cancer (CRC) is hampered by the frequent development of oxaliplatin (OXA) resistance. This study investigated whether exogenous L-carnitine (CAR) modulates OXA sensitivity in CRC cells and whether any such effect depends on fatty acid oxidation (FAO). Methods: The effects of carnitine, with or without OXA, on cell viability, proliferation, migration, oxygen consumption, apoptosis, cell-cycle distribution, and intracellular reactive oxygen species (ROS) were evaluated in HCT116 parental cells and an OXA-resistant subline (HCT116/L), using CCK-8, colony formation, wound healing, Seahorse XF analysis, flow cytometry, and ROS fluorescence probes. Results: In vitro , exogenous carnitine dose-dependently reduced CRC cell viability, proliferation, migration, and respiration, and promoted apoptosis. Co-treatment with carnitine partially attenuated the anti-proliferative and pro-apoptotic effects of OXA in HCT116/L cells, consistent with reduced chemosensitivity. This effect was accompanied by a partial restoration of fatty-acid-dependent respiration and a reduction in OXA-induced ROS accumulation. Conclusion: In OXA-resistant HCT116/L (MSI-H) cells, exogenous carnitine is associated with reduced OXA sensitivity, an effect that requires fatty acid oxidation. These findings identify carnitine-FAO metabolism as a potential determinant of OXA response; whether limiting carnitine availability can restore OXA sensitivity in vivo remains a hypothesis to be tested.