Acute pancreatitis (AP) is a complex inflammatory condition that can lead to systemic inflammatory responses and multiple organ dysfunction. This study investigates the role of Galectin-3 (Gal-3), a β-galactoside-binding lectin, in modulating acquired immune responses in AP. Acute pancreatitis was induced by ligation of the bile-pancreatic duct in wild-type and Galectin-3-deficient C57BL/6 mice. We determined the phenotypic and molecular features of inflammatory cells, serum concentrations of amylase, pancreatic trypsin activity, and pancreatic and lung pathology. Galectin-3 deficiency decreased the total number of CD3⁺CD49⁻ T cells and CD4⁺ T helper cells, downregulated the production of inflammatory cytokine and IFN-γ, and increased the accumulation of IL-10-producing Foxp3⁺ T regulatory cells and regulatory CD4⁺ T cells in the pancreata of diseased animals. The deletion of Galectin-3 ameliorates acute pancreatitis characterized by lowering serum amylase concentration and pancreatic trypsin activity, and attenuating of the histopathology of the lung. These findings shed light on the role of Galectin-3 in acquired immune response in acute pancreatitis and identify Galectin-3 as an attractive target for investigation of the immunopathogenesis of disease and for consideration as a potential therapeutic target for patients with acute inflammatory disease of the pancreas.

This study examined associations between self-rated health (SRH) and burnout dimensions among prehospital emergency physicians. This cross-sectional study included a convenience sample of 151 physicians from one emergency medical service in Belgrade, Serbia. Burnout was assessed using the Maslach Burnout Inventory–Human Services Survey and SRH using a single SF-36 general-health item. Ordinal models examined three ordered SRH categories (excellent/very good, good, and fair/poor), with burnout dimensions entered separately and jointly, adjusting for age, sex, professional qualification, and chronic disease. Binary sensitivity analyses compared fair/poor with excellent/very good/good health. Higher emotional exhaustion was associated with less favourable SRH in the separate adjusted ordinal model (OR per 10-point increase: 1.31; 95% CI 1.04–1.64). After mutual adjustment for burnout dimensions, the estimate remained similar but was less precise (OR 1.30; 95% CI 0.96–1.75). Evidence was also inconclusive in the adjusted binary analysis. Depersonalisation and reduced personal accomplishment showed no clear adjusted associations with SRH. Unadjusted associations of shift work and daily working hours with SRH were inconclusive. Emotional exhaustion may be associated with physicians’ perceived health, although the evidence varied across models. The cross-sectional design precludes conclusions about direction or causality; longitudinal studies are needed.

Introduction: Palpitations are a common symptom and are usually benign. However, they may be the sole manifestation of life-threatening ventricular tachycardia and significant coronary artery disease. Case report: A 57-year-old man was awakened from sleep by a sensation of pounding in his chest and irregular heartbeats. He reported no chest pain or loss of consciousness. His medical history included type 2 diabetes mellitus and hyperlipidaemia. His blood pressure was 150/102 mmHg, and his heart rate was 165 beats/min. An electrocardiogram (ECG) revealed wide-QRS-complex ventricular tachycardia with a left bundle branch block morphology at a rate of approximately 160 beats/min. Intravenous amiodarone restored sinus rhythm. Further diagnostic evaluation revealed significant stenosis of the left anterior descending (LAD) coronary artery. Percutaneous coronary intervention was subsequently performed, with implantation of a single drug-eluting stent and drug-coated balloon angioplasty of the mid-LAD segment. Conclusion: Palpitations can be the sole symptom of a serious arrhythmia. Early prehospital assessment, including ECG, continuous monitoring, and evaluation of haemodynamic status, is essential for prompt recognition and initial management, while appropriate transport ensures timely access to definitive cardiac care.

Short bowel syndrome (SBS) is the leading cause of chronic intestinal failure in adults and most commonly follows extensive small-bowel resection. The resulting loss of absorptive surface and regulatory feedback leads to a spectrum of malabsorption syndromes, ranging from compensated intestinal insufficiency to intestinal failure requiring long-term parenteral support. Clinical outcomes are determined more by postoperative anatomy than by residual length alone, particularly the presence of colon continuity and the preservation of the distal ileum and the ileocecal region. The pathophysiology of SBS integrates reduced absorptive capacity, accelerated transit, gastric hypersecretion, disordered bile acid handling, microbiome perturbation, and impaired enteroendocrine signalling. Intestinal adaptation, driven by luminal nutrients and trophic hormones such as GLP-2, can partially restore function over months to years, enabling stepwise reduction of parenteral support in selected patients. Modern care is centred on structured intestinal rehabilitation delivered by multidisciplinary teams, combining individualised fluid-electrolyte strategy, optimised oral/enteral nutrition, targeted pharmacotherapy to control secretion and motility, prevention and management of catheter-related complications, and selective reconstructive surgery. Disease-modifying therapy with GLP-2 analogues can reduce parenteral support requirements in SBS-associated intestinal failure, while transplantation remains reserved for refractory, life-threatening complications. This review summarises current concepts and evidence-based principles for diagnosis, phenotype stratification, rehabilitation, and long-term surveillance in adult SBS.

Epidermolysis bullosa (EB) is a hereditary multisystemic disease caused by genetic defects in the skin's structural proteins. Depending on the type of disease, symptoms vary from localised fragility and bullae to a widespread generalised form, including extracutaneous manifestations. In the most severe forms, EB causes death in the earliest period of life. The treatment of EB is complex and usually requires the involvement of several different specialists. Without curative therapy, treatment is oriented towards supportive care, symptom control, and preventing mild to severe complications. Vector gene therapy Vyjuvek (beremagene geperpavec), based on the herpes simplex virus type 1, is a new hope for treating wounds in patients older than six months who suffer from dystrophic forms of EB.