Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (n_Total = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents ( $${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$µV̇ = 23.98 ± 1.04 l/min, μ_P = −0.78 ± 0.63 hPa) and primed porcine lungs ( $${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$µV̇ = 18.87 ± 2.49 l/min, μ_P = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.

The project Integrating the Energy System (IES) Austria recognises interoperability as key enabler for the deployment of smart energy systems. Interoperability is covered in the Strategic Energy Technology Plan (SET-Plan) activity A4-IA0-5 and provides an added value because it enables new business options for most stakeholders. The communication of smart energy components and systems shall be interoperable to enable smooth data exchange, and thereby, the on demand integration of heterogeneous systems, components and services. The approach developed and proposed by IES, adopts the holistic methodology from the consortium Integrating the Healthcare Enterprise (IHE), established by information technology (IT) vendors in the health sector and standardised in the draft technical report ISO DTR 28380-1, to foster interoperable smart energy systems. The paper outlines the adopted IES workflow in detail and reports on lesson learnt when trial Integration Profiles based on IEC 61850 were tested at the first Connectathon Energy instalment, organised in conjunction with the IHE Connectathon Europe 2018. The IES methodology is found perfectly applicable for smart energy systems and successfully enables peer-to-peer interoperability testing among vendors. The public specification of required Integration Profiles, to be tested at subsequent Connectathon Energy events, is encouraged.

Dry powder inhalers are used by a large number of patients worldwide to treat respiratory diseases. The objective of this work is to experimentally investigate changes in aerosol particle diameter and particle number concentration of pharmaceutical aerosols generated by four dry powder inhalers under realistic inhalation and exhalation conditions. To simulate patients undergoing inhalation therapy, the active respiratory system model (xPULM™) was used. A mechanical upper airway model was developed, manufactured, and introduced as a part of the xPULM™ to represent the human upper respiratory tract with high fidelity. Integration of optical aerosol spectrometry technique into the setup allowed for evaluation of pharmaceutical aerosols. The results show that there is a significant difference (p < 0.05) in mean particle diameter between inhaled and exhaled particles with the majority of the particles depositing in the lung, while particles with the size of (>0.5 μm) are least influenced by deposition mechanisms. The fraction of exhaled particles ranges from 2.13% (HandiHaler^®) over 2.94% (BreezHaler^®), and 6.22% (Turbohaler^®) to 10.24% (Ellipta^®). These values are comparable to previously published studies. Furthermore, the mechanical upper airway model increases the resistance of the overall system and acts as a filter for larger particles (>3 μm). In conclusion, the xPULM™ active respiratory system model is a viable option for studying interactions of pharmaceutical aerosols and the respiratory tract regarding applicable deposition mechanisms. The model strives to support the reduction of animal experimentation in aerosol research and provides an alternative to experiments with human subjects.

Interoperability in the Energy System is an important topic for the development of Smart Grids. In this paper we introduce a structured approach to solve the complex interoperability issues of connected systems and sub-systems based on experiences from the healthcare enterprise, where formerly rather closed systems were successfully migrated towards more open system. This approach combines well-established use case methodologies from the software development domain with benefits of the concept of integration profiles which can be found in the healthcare domain. The combination of the two methods is demonstrated by developing an integration profile for an application example from the Smart Grid domain; the virtual power plant operation use case. Using the presented method, a step-by-step guideline for implementers could be created. The profiling methodology seems to be an appropriate method to approach complex interoperability issues of Energy Systems and may be expanded to other fields.