The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model. The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes. Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p<0.001) and mean thicknesses of TMs (p<0.001), but there were no differences between Group 1 and Group 3. In respect of MS detected by otomicroscopy, a statistically significant difference was determined between Groups 1 and 2 (p<0.001) and between Groups 2 and 3 (p<0.01), but there was no significant difference between Group 1 and Group 3 (p=0.575). Orally administered CMN can prevent myringosclerosis formation in experimentally induced myringotomies.

Duyu organları ile yakın ilişkisi olan kulak, burun, boğaz ve baş boyun cerrahisi tıbbın branşlaşmaya başladığı ilk dönemlerde ortaya çıkmış olup klinik pratikte kapsamı genişleyerek zenginleşen bir branş olarak önemini korumaktadır. Günümüzde otoloji, rinoloji, laringoloji, fasiyal plastik ve rekonstruktif cerrahi, baş boyun cerrahisi, pediatrik kulak burun boğaz ve uyku tıbbı başlıkları bu branşın konuları arasında bulunur. İçeriğindeki genişliğin artması yazılı kaynakların pratik kullanıma uygun yazılmasının önemini ortaya çıkarmaktadır. Bu amaçla yazarları uzman hekimlerden oluşturulan ve okuyucularının da uzman hekim olması hedeflenen kitabımızda bilim dili olarak Türkçenin yalın olarak kullanılması, güncel kaynakların ele alınması konu için dönüm noktası olan yayınların ve analizlerin atlanmamasına özen gösterilmesi ve kullanımının kolay olması editörler ve yazarlarımızın amacı olmuştur.

Stromal Vascular fraction/gel (SVF/gel) is prepared mechanically from autologous adipose tissue, and it is known for its regenerative and anti-inflammatory properties. To assess histopathological effects of adipose tissue-derived SVF/gel and nasal steroids on nasal mucosal healing. Forty-two Wistar Albino rats with right nasal mucosal injury were randomly divided into three groups: control (saline), Mometasone Furoate (MF), and SVF/gel. Control group (n = 14) received saline for 7 days, while MF group (n = 14) was administered MF to the right nasal cavity for 7 days. SVF/gel group (n = 14) was treated once with SVF/gel in the right nasal cavity. Histological analysis on days 14 and 28 post-injury focused on evaluating epithelial thickness, inflammation, disarray, subepithelial thickness, goblet cell count, subepithelial fibrosis, presence of ciliated cells, lacunae, adhesion, and neo-osteogenesis. When comparing the MF and SVF/gel groups, statistically significant differences were found on day 14 in indices of epithelial thickness, subepithelial thickness, goblet cells, subepithelial fibrosis, and ciliated cells. On day 28, SVF/gel group exhibited higher ciliated cell counts and lower subepithelial fibrosis values (p = .027; p = .016). Additionally, epithelial disarray, adhesions, lacunae, and neo-osteogenesis were not observed in the SVF/gel group. SVF/gel accelerates re-epithelialization, reduces fibrosis and adhesions, and enhances cilia formation compared to nasal steroids. These findings suggest that SVF/gel is an autologous and cost-effective treatment for improving nasal mucosal healing post-injury.

Background/Objectives: Vitamin D deficiency has been associated with the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV), but its influence on the immediate success of canalith repositioning maneuvers remains uncertain. This study investigated the relationship between serum vitamin D levels and the first-attempt success of the Epley maneuver in patients with posterior canal BPPV (PC-BPPV). Methods: This prospective observational study included 140 consecutive adults with objectively confirmed unilateral PC-BPPV. Serum 25-hydroxyvitamin D levels were measured at presentation before treatment. All patients underwent a standardized Epley maneuver. First-attempt success was defined as complete resolution of positional vertigo and disappearance of positional nystagmus on the Dix–Hallpike test at the one-week follow-up visit. Serum vitamin D levels were analyzed both as a continuous variable and according to laboratory reference ranges: deficiency (<50 nmol/L), insufficiency (50–75 nmol/L), and sufficiency (75–250 nmol/L). Results: The Epley maneuver was successful after the first attempt in 74 of 140 patients (52.9%). In the primary, pre-specified analysis, first-attempt success was more frequent among patients with serum vitamin D ≥50 nmol/L than <50 nmol/L (60.9% vs. 46.1%; OR 1.83, 95% CI 0.93–3.59, p = 0.079), a difference that did not reach statistical significance. In unadjusted exploratory analyses, patients with first-attempt success had significantly higher median serum vitamin D levels than those with treatment failure (52.2 [IQR, 30.0–68.4] vs. 36.8 [IQR, 21.3–66.1] nmol/L, p = 0.029), and success rates numerically increased across the three-tier classification (46.1%, 62.2%, 59.3%), without a clear dose–response pattern, neither the overall comparison (p = 0.208) nor pairwise subgroup comparisons reaching statistical significance. In a multivariable model adjusting for age, sex, and month of enrolment, vitamin D remained independently, though modestly, associated with first-attempt success (adjusted OR 1.14 per 10 nmol/L, 95% CI 1.00–1.29). Conclusions: The pre-specified primary comparison of first-attempt Epley maneuver success between vitamin D-deficient and non-deficient patients did not reach statistical significance, although the point estimate favored higher success in the non-deficient group (OR 1.83, 95% CI 0.93–3.59). An exploratory, initially unadjusted analysis suggested a positive, modest association between serum vitamin D as a continuous variable and first-attempt success; this association persisted after multivariable adjustment (adjusted OR 1.14, 95% CI 1.00–1.29) but did not follow a clear dose–response pattern across categorical vitamin D thresholds. These findings should be regarded as hypothesis-generating rather than establishing a definitive prognostic role for vitamin D, and larger, adequately powered multicenter studies are needed to confirm them.