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Mr. Parise Adadi
University Of Otago

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Opinion
Published: 13 July 2021 in Biomolecules
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Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines.

ACS Style

Kenneth Lundstrom; Debmalya Barh; Bruce Uhal; Kazuo Takayama; Alaa Aljabali; Tarek Abd El-Aziz; Amos Lal; ElRashdy Redwan; Parise Adadi; Gaurav Chauhan; Samendra Sherchan; Gajendra Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas Bazan; Sk Hassan; Pritam Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-Da-Cruz; Yogendra Mishra; Giorgio Palu; Adam Brufsky; Murtaza Tambuwala; Vladimir Uversky. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules 2021, 11, 1020 .

AMA Style

Kenneth Lundstrom, Debmalya Barh, Bruce Uhal, Kazuo Takayama, Alaa Aljabali, Tarek Abd El-Aziz, Amos Lal, ElRashdy Redwan, Parise Adadi, Gaurav Chauhan, Samendra Sherchan, Gajendra Azad, Nima Rezaei, Ángel Serrano-Aroca, Nicolas Bazan, Sk Hassan, Pritam Panda, Pabitra Pal Choudhury, Damiano Pizzol, Ramesh Kandimalla, Wagner Baetas-Da-Cruz, Yogendra Mishra, Giorgio Palu, Adam Brufsky, Murtaza Tambuwala, Vladimir Uversky. COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Biomolecules. 2021; 11 (7):1020.

Chicago/Turabian Style

Kenneth Lundstrom; Debmalya Barh; Bruce Uhal; Kazuo Takayama; Alaa Aljabali; Tarek Abd El-Aziz; Amos Lal; ElRashdy Redwan; Parise Adadi; Gaurav Chauhan; Samendra Sherchan; Gajendra Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas Bazan; Sk Hassan; Pritam Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-Da-Cruz; Yogendra Mishra; Giorgio Palu; Adam Brufsky; Murtaza Tambuwala; Vladimir Uversky. 2021. "COVID-19 Vaccines and Thrombosis—Roadblock or Dead-End Street?" Biomolecules 11, no. 7: 1020.

Journal article
Published: 16 April 2021 in International Journal of Biological Macromolecules
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The current Coronavirus Disease 19 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) shows similar pathology to MERS and SARS-CoV, with a current estimated fatality rate of 1.4%. Open reading frame 10 (ORF10) is a unique SARS-CoV-2 accessory protein, which contains eleven cytotoxic T lymphocyte (CTL) epitopes each of nine amino acids in length. Twenty-two unique SARS-CoV-2 ORF10 variants have been identified based on missense mutations found in sequence databases. Some of these mutations are predicted to decrease the stability of ORF10 in silico physicochemical and structural comparative analyses were carried out on SARS-CoV-2 and Pangolin-CoV ORF10 proteins, which share 97.37% amino acid (aa) homology. Though there is a high degree of ORF10 protein similarity of SARS-CoV-2 and Pangolin-CoV, there are differences of these two ORF10 proteins related to their sub-structure (loop/coil region), solubility, antigenicity and shift from strand to coil at aa position 26 (tyrosine). SARS-CoV-2 ORF10, which is apparently expressed in vivo since reactive T cell clones are found in convalescent patients should be monitored for changes which could correlate with the pathogenesis of COVID-19.

ACS Style

Sk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Alaa A.A. Aljabali; Kenneth Lundstrom; Bruce D. Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2. International Journal of Biological Macromolecules 2021, 181, 801 -809.

AMA Style

Sk. Sarif Hassan, Diksha Attrish, Shinjini Ghosh, Pabitra Pal Choudhury, Vladimir N. Uversky, Alaa A.A. Aljabali, Kenneth Lundstrom, Bruce D. Uhal, Nima Rezaei, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M. Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Amos Lal, Giorgio Palù, Kazuo Takayama, Ángel Serrano-Aroca, Debmalya Barh, Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2. International Journal of Biological Macromolecules. 2021; 181 ():801-809.

Chicago/Turabian Style

Sk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Alaa A.A. Aljabali; Kenneth Lundstrom; Bruce D. Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M. Brufsky. 2021. "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2." International Journal of Biological Macromolecules 181, no. : 801-809.

Editorial
Published: 09 March 2021 in Biomolecules
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Phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is focused on a single isolate of bat coronaviruses (bat CoVs) which does not adequately represent genetically related coronaviruses (CoVs)

ACS Style

Murat Seyran; Sk. Hassan; Vladimir Uversky; Pabitra Pal Choudhury; Bruce Uhal; Kenneth Lundstrom; Diksha Attrish; Nima Rezaei; Alaa Aljabali; Shinjini Ghosh; Damiano Pizzol; Parise Adadi; Tarek El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Azad; Samendra Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam Brufsky. Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks. Biomolecules 2021, 11, 398 .

AMA Style

Murat Seyran, Sk. Hassan, Vladimir Uversky, Pabitra Pal Choudhury, Bruce Uhal, Kenneth Lundstrom, Diksha Attrish, Nima Rezaei, Alaa Aljabali, Shinjini Ghosh, Damiano Pizzol, Parise Adadi, Tarek El-Aziz, Ramesh Kandimalla, Murtaza Tambuwala, Amos Lal, Gajendra Azad, Samendra Sherchan, Wagner Baetas-Da-Cruz, Giorgio Palù, Adam Brufsky. Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks. Biomolecules. 2021; 11 (3):398.

Chicago/Turabian Style

Murat Seyran; Sk. Hassan; Vladimir Uversky; Pabitra Pal Choudhury; Bruce Uhal; Kenneth Lundstrom; Diksha Attrish; Nima Rezaei; Alaa Aljabali; Shinjini Ghosh; Damiano Pizzol; Parise Adadi; Tarek El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Azad; Samendra Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam Brufsky. 2021. "Urgent Need for Field Surveys of Coronaviruses in Southeast Asia to Understand the SARS-CoV-2 Phylogeny and Risk Assessment for Future Outbreaks." Biomolecules 11, no. 3: 398.

Preprint
Published: 15 January 2021
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Therapeutic options for the highly pathogenic human Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) causing the current pandemic Coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19, such as hydroxychloroquine, remdesivir and lopinavir/ritonavir, have shown little or no effect in the clinic. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2 mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g. membrane distortion), which is characterized by a low risk of antimicrobial resistance. In this review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 12 enveloped positive-sense single-stranded RNA viruses similar to SARS-CoV-2. CBNs with low or no toxicity to the humans are promising therapeutics against COVID-19 pneumonia complex with other viruses, bacteria and fungi, including those that are multidrug-resistant.

ACS Style

Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Bruce D. Uhal; Adam M. Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era. 2021, 1 .

AMA Style

Ángel Serrano-Aroca, Kazuo Takayama, Alberto Tuñón-Molina, Murat Seyran, Sk. Sarif Hassan, Pabitra Pal Choudhury, Vladimir N. Uversky, Kenneth Lundstrom, Parise Adadi, Giorgio Palù, Alaa A. A. Aljabali, Gaurav Chauhan, Ramesh Kandimalla, Murtaza M. Tambuwala, Amos Lal, Bruce D. Uhal, Adam M. Brufsky. Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era. . 2021; ():1.

Chicago/Turabian Style

Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk. Sarif Hassan; Pabitra Pal Choudhury; Vladimir N. Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A. A. Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M. Tambuwala; Amos Lal; Bruce D. Uhal; Adam M. Brufsky. 2021. "Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial Resistant Era." , no. : 1.

Journal article
Published: 11 January 2021 in Sustainability
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The exponential increase in the population of Ghana and the need to meet the population’s food security needs while creating job opportunities have necessitated the implementation of the Planting for Food and Jobs (PFJ) initiative by the Government of Ghana (GoG). Using the strengths, weaknesses, opportunities, and threats (SWOT) analytical tool, we SWOT of the PFJ initiative. We further complemented the study with the analytic hierarchy process (AHP) tool to rank the various criteria (factors) identified under the SWOT analysis. The study identified favorable environmental conditions as the highest strength, which recorded 59.3%, followed by agricultural lands availability (21.8%). Inadequate of financial services was identified as the highest weakness (55.8%), followed by over-reliance on climatic conditions (25.9%). High export potential relative to agricultural products in the country was identified as the highest opportunity, which recorded a weight of 50.3%. The One District One Factory (1D1F) initiative came up as the second highest opportunity. Negative ramification of climate change was identified as the main threat to Ghana’s agricultural sector (57.9%), followed by the importation of basic food products (25%).

ACS Style

Ernest Ali; Ephraim Agyekum; Parise Adadi. Agriculture for Sustainable Development: A SWOT-AHP Assessment of Ghana’s Planting for Food and Jobs Initiative. Sustainability 2021, 13, 628 .

AMA Style

Ernest Ali, Ephraim Agyekum, Parise Adadi. Agriculture for Sustainable Development: A SWOT-AHP Assessment of Ghana’s Planting for Food and Jobs Initiative. Sustainability. 2021; 13 (2):628.

Chicago/Turabian Style

Ernest Ali; Ephraim Agyekum; Parise Adadi. 2021. "Agriculture for Sustainable Development: A SWOT-AHP Assessment of Ghana’s Planting for Food and Jobs Initiative." Sustainability 13, no. 2: 628.

Journal article
Published: 13 December 2020 in Molecules
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Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

ACS Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M. Brufsky. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. Molecules 2020, 25, 5906 .

AMA Style

Sk. Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A. A. Aljabali, Bruce D. Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N. Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M. Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M. Brufsky. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features. Molecules. 2020; 25 (24):5906.

Chicago/Turabian Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A. A. Aljabali; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N. Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M. Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M. Brufsky. 2020. "Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features." Molecules 25, no. 24: 5906.

Review
Published: 28 October 2020 in Fermentation
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Since time immemorial, ginger has been widely used as a food spice, providing aromatic odor and pungent taste, and as a medicinal plant, with various therapeutic effects such as antioxidant, anti-inflammatory, and analgesic, among others. It has long been an integral constituent of most herbal medicines in Africa, China and India. Its medicinal properties are largely attributed to its outstanding amount of phenolics which include gingerols, paradols, zingerones, and many others. With consumer preference gradually and remarkably shifting from high-calorie towards low-calorie and functional beverages, the demand for ginger beer is flourishing at a faster rate. Currently, the ginger beer market is dominated by the United States. The demand for ginger beer is, however, debilitated by using artificial ingredients. Nonetheless, the use of natural ginger extract enriches beer with putative bioactive phytoconstituents such as shagaol, gingerone, zingerone, ginger flavonoids and essential oils, as well as essential nutritional components including proteins, vitamins and minerals, to promote general wellbeing of consumer. This paper presents an overview of the phytoconstituents of ginger as well as the overall biological activities they confer to the consumer. In addition, the market trend as well as the production technology of ginger beer using natural ginger extract is described here.

ACS Style

Christabel Nutakor; Justice A. Essiedu; Parise Adadi; Osman N. Kanwugu. Ginger Beer: An Overview of Health Benefits and Recent Developments. Fermentation 2020, 6, 102 .

AMA Style

Christabel Nutakor, Justice A. Essiedu, Parise Adadi, Osman N. Kanwugu. Ginger Beer: An Overview of Health Benefits and Recent Developments. Fermentation. 2020; 6 (4):102.

Chicago/Turabian Style

Christabel Nutakor; Justice A. Essiedu; Parise Adadi; Osman N. Kanwugu. 2020. "Ginger Beer: An Overview of Health Benefits and Recent Developments." Fermentation 6, no. 4: 102.

Editorial
Published: 22 October 2020 in Viruses
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The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational “hot spot” as only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted during human-to-human transmission and based on available data, the isolated SARS-CoV-2 genomes derive from a common origin. Before the origin of SARS-CoV-2 can be confirmed additional research is required

ACS Style

Kenneth Lundstrom; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Sk. Sarif Hassan; Antonio Soares; Ramesh Kandimalla; Murtaza M. Tambuwala; Alaa A. A. Aljabali; Gajendra Kumar Azad; Pabitra Pal Choudhury; Vladimir N. Uversky; Samendra P. Sherchan; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. The Importance of Research on the Origin of SARS-CoV-2. Viruses 2020, 12, 1203 .

AMA Style

Kenneth Lundstrom, Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El-Aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Murtaza M. Tambuwala, Alaa A. A. Aljabali, Gajendra Kumar Azad, Pabitra Pal Choudhury, Vladimir N. Uversky, Samendra P. Sherchan, Bruce D. Uhal, Nima Rezaei, Adam M. Brufsky. The Importance of Research on the Origin of SARS-CoV-2. Viruses. 2020; 12 (11):1203.

Chicago/Turabian Style

Kenneth Lundstrom; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Sk. Sarif Hassan; Antonio Soares; Ramesh Kandimalla; Murtaza M. Tambuwala; Alaa A. A. Aljabali; Gajendra Kumar Azad; Pabitra Pal Choudhury; Vladimir N. Uversky; Samendra P. Sherchan; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. 2020. "The Importance of Research on the Origin of SARS-CoV-2." Viruses 12, no. 11: 1203.

Preprint content
Published: 09 October 2020
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Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.

ACS Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Vladimir N Uversky; Bruce Uhal; Kenneth Lundstrom; Nima Rezaei; Alaa A.A Aljabali; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Angel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam Brufsky. Possible transmission flow of SARS-CoV-2 based on ACE2 features. 2020, 1 .

AMA Style

Sk. Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Vladimir N Uversky, Bruce Uhal, Kenneth Lundstrom, Nima Rezaei, Alaa A.A Aljabali, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza Tambuwala, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Angel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam Brufsky. Possible transmission flow of SARS-CoV-2 based on ACE2 features. . 2020; ():1.

Chicago/Turabian Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Vladimir N Uversky; Bruce Uhal; Kenneth Lundstrom; Nima Rezaei; Alaa A.A Aljabali; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza Tambuwala; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Kazuo Takayama; Angel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam Brufsky. 2020. "Possible transmission flow of SARS-CoV-2 based on ACE2 features." , no. : 1.

Book chapter
Published: 07 October 2020 in Mycotoxins and Food Safety [Working Title]
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Cereals and legumes are the major staples across the globe, thus providing nutrition to humans, and their by-products utilized as animal feeds. However, mycotoxins synthesized by fungi contaminate these grains on the field during cultivation and are transferred to the storage centers. These fungi infect and deteriorate stored grains, thereby tampering with food security. Moreover, the deterioration decreases nutrient content and alters the physicochemical properties of grains. The current conventional methods used to reduce grain contamination are becoming ineffecitive, coupled with the detrimental health effects it has on the consumer and to the environment. Herein, we present an overview of the use of nanoparticles (NPs) as an alternative and novel method of reducing mycotoxin biosynthesis due to their potent biocidal properties. Silver nanoparticles (AgNPs) are considered and have shown promising and effective fungicidal properties against important storage fungi, and pests hence could be utilized in the agriculture and food sector for a vast myriad of applications. These may help to either minimize/eradicate the exposure to the mycotoxins and its adverse health effects, hence contributing to the holistic growth and development of people.

ACS Style

Daniel Nsengumuremyi; Parise Adadi; Gavers K. Oppong; Nadezhda V. Barakova; Elena F. Krivoshapkina. The Potential Application of Nanoparticles on Grains during Storage. Part 1: An Overview of Inhibition against Fungi and Mycotoxin Biosynthesis. Mycotoxins and Food Safety [Working Title] 2020, 1 .

AMA Style

Daniel Nsengumuremyi, Parise Adadi, Gavers K. Oppong, Nadezhda V. Barakova, Elena F. Krivoshapkina. The Potential Application of Nanoparticles on Grains during Storage. Part 1: An Overview of Inhibition against Fungi and Mycotoxin Biosynthesis. Mycotoxins and Food Safety [Working Title]. 2020; ():1.

Chicago/Turabian Style

Daniel Nsengumuremyi; Parise Adadi; Gavers K. Oppong; Nadezhda V. Barakova; Elena F. Krivoshapkina. 2020. "The Potential Application of Nanoparticles on Grains during Storage. Part 1: An Overview of Inhibition against Fungi and Mycotoxin Biosynthesis." Mycotoxins and Food Safety [Working Title] , no. : 1.

Preprint content
Published: 06 September 2020
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The global public health is endangered due to COVID-19 pandemic, which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Despite having similar pathology to MERS and SARS-CoV, the infection fatality rate of SARS-CoV-2 is likely lower than 1%. SARS-CoV-2 has been reported to be uniquely characterized by the accessory protein ORF10, which contains eleven cytotoxic T lymphocyte (CTL) epitopes of nine amino acids length each, across various human leukocyte antigen (HLA) subtypes. In this study, all missense mutations found in sequence databases were examined across twnety-two unique SARS-CoV-2 ORF10 variants that could possibly alter viral pathogenicity. Some of these mutations decrease the stability of ORF10, e.g. I4L and V6I were found in the MoRF region of ORF10 which may also possibly contribute to Intrinsic protein disorder. Furthermore, a physicochemical and structural comparative analysis was carried out on SARS-CoV-2 and Pangolin-CoV ORF10 proteins, which share 97.37% amino acid homology. The high degree of physicochemical and structural similarity of ORF10 proteins of SARS-CoV-2 and Pangolin-CoV open questions about the architecture of SARS-CoV-2 due to the disagreement of these two ORF10 proteins over their sub-structure (loop/coil region), solubility, antigenicity and change from the strand to coil at amino acid position 26, where tyrosine is present. Altogether, SARS-CoV-2 ORF10 is a promising pharmaceutical target and a protein which should be monitored for changes which correlate to change pathogenesis and clinical course of COVID-19 infection.

ACS Style

Sk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Alaa A. A. Aljabali; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-COV-2. 2020, 1 .

AMA Style

Sk. Sarif Hassan, Diksha Attrish, Shinjini Ghosh, Pabitra Pal Choudhury, Vladimir N. Uversky, Bruce D. Uhal, Kenneth Lundstrom, Nima Rezaei, Alaa A. A. Aljabali, Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El-Aziz, Antonio Soares, Ramesh Kandimalla, Murtaza Tambuwala, Amos Lal, Gajendra Kumar Azad, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Giorgio Palù, Adam M. Brufsky. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-COV-2. . 2020; ():1.

Chicago/Turabian Style

Sk. Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N. Uversky; Bruce D. Uhal; Kenneth Lundstrom; Nima Rezaei; Alaa A. A. Aljabali; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Murtaza Tambuwala; Amos Lal; Gajendra Kumar Azad; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Giorgio Palù; Adam M. Brufsky. 2020. "Notable sequence homology of the ORF10 protein introspects the architecture of SARS-COV-2." , no. : 1.

Letter to the editor
Published: 03 September 2020 in Journal of Medical Virology
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There is a consensus that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) originated naturally from Bat coronaviruses (CoVs), in particular RaTG13. However, the SARS‐CoV‐2 host tropism/adaptation pattern has significant discrepancies compared to other CoVs, raising questions concerning the proximal origin of SARS‐CoV‐2. This article is protected by copyright. All rights reserved.

ACS Style

Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El‐Aziz; Sk. Sarif Hassan; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Murtaza Tambuwala; Alaa A. A. Aljabali; Amos Lal; Gajendra Kumar Azad; Pabitra Pal Choudhury; Vladimir N. Uversky; Samendra P. Sherchan; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. Questions concerning the proximal origin of SARS‐CoV‐2. Journal of Medical Virology 2020, 93, 1204 -1206.

AMA Style

Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El‐Aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Kenneth Lundstrom, Murtaza Tambuwala, Alaa A. A. Aljabali, Amos Lal, Gajendra Kumar Azad, Pabitra Pal Choudhury, Vladimir N. Uversky, Samendra P. Sherchan, Bruce D. Uhal, Nima Rezaei, Adam M. Brufsky. Questions concerning the proximal origin of SARS‐CoV‐2. Journal of Medical Virology. 2020; 93 (3):1204-1206.

Chicago/Turabian Style

Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El‐Aziz; Sk. Sarif Hassan; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Murtaza Tambuwala; Alaa A. A. Aljabali; Amos Lal; Gajendra Kumar Azad; Pabitra Pal Choudhury; Vladimir N. Uversky; Samendra P. Sherchan; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. 2020. "Questions concerning the proximal origin of SARS‐CoV‐2." Journal of Medical Virology 93, no. 3: 1204-1206.

Preprint content
Published: 26 August 2020
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Immune evasion is one of the unique characteristics of COVID-19 attributed to the ORF8 protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This protein is involved in modulating the host adaptive immunity through downregulating MHC (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the interferon mediated antiviral response of the host. To understand the immune perspective of the host with respect to the ORF8 protein, a comprehensive study of the ORF8 protein as well as mutations possessed by it, is performed. Chemical and structural properties of ORF8 proteins from different hosts, that is human, bat and pangolin, suggests that the ORF8 of SARS-CoV-2 and Bat RaTG13-CoV are very much closer related than that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 (SARS-CoV-2) are grouped into four classes based on their predicted effects. Based on geolocations and timescale of collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were endorsed upon sequence similarity and amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of rapid evolving SARS-CoV-2 through the ORF8.

ACS Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabirtra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Muhammed Abd El Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Murtaza Tambuwala; Alaa A. A. Aljabali; Amos Lal; Gajendra Kumar Azad; Vladimir N. Uversky; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. A unique view of SARS-CoV-2 through the lens of ORF8 protein. 2020, 1 .

AMA Style

Sk. Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabirtra Pal Choudhury, Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Muhammed Abd El Aziz, Antonio Soares, Ramesh Kandimalla, Kenneth Lundstrom, Murtaza Tambuwala, Alaa A. A. Aljabali, Amos Lal, Gajendra Kumar Azad, Vladimir N. Uversky, Samendra P. Sherchan, Wagner Baetas-Da-Cruz, Bruce D. Uhal, Nima Rezaei, Adam M. Brufsky. A unique view of SARS-CoV-2 through the lens of ORF8 protein. . 2020; ():1.

Chicago/Turabian Style

Sk. Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabirtra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Muhammed Abd El Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Murtaza Tambuwala; Alaa A. A. Aljabali; Amos Lal; Gajendra Kumar Azad; Vladimir N. Uversky; Samendra P. Sherchan; Wagner Baetas-Da-Cruz; Bruce D. Uhal; Nima Rezaei; Adam M. Brufsky. 2020. "A unique view of SARS-CoV-2 through the lens of ORF8 protein." , no. : 1.

Review
Published: 21 July 2020 in Journal of Medical Virology
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Since its first appearance in Wuhan, China, SARS‐CoV‐2 has rapidly spread throughout the world and has become a global pandemic. Several medical comorbidities have been identified as risk factors for COVID‐19. However, it remains unclear whether people with people living with HIV (PLWH) are at an increased risk of COVID‐19 and severe disease manifestation, with controversial suggestion that HIV‐infected individuals could be protected from severe COVID‐19 by means of antiretroviral therapy (ART) or HIV‐related immunosuppression. Several cases of coinfection with HIV and SARS‐CoV‐2 have been reported from different parts of the globe. This review seeks to provide a holistic overview of SARS‐CoV‐2 infection in PLWH. This article is protected by copyright. All rights reserved.

ACS Style

Osman N. Kanwugu; Parise Adadi. HIV/SARS‐CoV‐2 coinfection: A global perspective. Journal of Medical Virology 2020, 93, 726 -732.

AMA Style

Osman N. Kanwugu, Parise Adadi. HIV/SARS‐CoV‐2 coinfection: A global perspective. Journal of Medical Virology. 2020; 93 (2):726-732.

Chicago/Turabian Style

Osman N. Kanwugu; Parise Adadi. 2020. "HIV/SARS‐CoV‐2 coinfection: A global perspective." Journal of Medical Virology 93, no. 2: 726-732.

Letter to the editor
Published: 04 June 2020 in Journal of Medical Virology
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As at the time of writing, the global confirmed cases of the coronavirus disease (COVID‐19) stands at 5,075,181 with 330,981 deaths and 1,936,331 recoveries1. According to the Canter for Disease Control, the aged and individuals with compromised immune systems due to infections (i.e., human immunodeficiency viruses (HIV), etc.) are at higher risk of contracting the COVID‐19. This article is protected by copyright. All rights reserved.

ACS Style

Parise Adadi; Osman N. Kanwugu. Living with HIV in the time of COVID‐19: A glimpse of hope. Journal of Medical Virology 2020, 93, 59 -60.

AMA Style

Parise Adadi, Osman N. Kanwugu. Living with HIV in the time of COVID‐19: A glimpse of hope. Journal of Medical Virology. 2020; 93 (1):59-60.

Chicago/Turabian Style

Parise Adadi; Osman N. Kanwugu. 2020. "Living with HIV in the time of COVID‐19: A glimpse of hope." Journal of Medical Virology 93, no. 1: 59-60.

Review
Published: 03 April 2020 in Beverages
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Sorghum beer (pito) is an indigenous alcoholic beverage peculiar to northern Ghana and parts of other West African countries. It is overwhelmed with calories, essential amino acids (such as lysine, etc.), B-group vitamins, and minerals. In recent years, there has been a growing demand for highly flavoured yet functional pito in Ghana; however, the local producers lack the prerequisite scientific expertise in designing such products. We propose the utilization of Tetrapleura tetraptera (TT) and Hibiscus sabdariffa (HS) as cheap and readily available materials in designing functional flavoured pito. The addition of TT and HS would not alter the fermentation profile but rather augment the starter with nutrients, thus improving the fermentation performance and shelf life of the final pito. In vitro and in vivo studies provide substantive evidence of antioxidant, nephro- and hepato-protective, renal/diuretic effect, anticholesterol, antidiabetic, and antihypertensive effects among others of the TT and HS, hence enriching the pito with health-promoting factors and consequently boosting the health of the consumer. Herein, we summarise the phytochemical, biological, pharmacological, and toxicological aspects of TT and HS as well as the technology involved in brewing the novel bioactive-flavoured pito. In addition, we also report the incidence of heavy metal in conventional pito.

ACS Style

Parise Adadi; Osman N. Kanwugu. Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties. Beverages 2020, 6, 22 .

AMA Style

Parise Adadi, Osman N. Kanwugu. Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties. Beverages. 2020; 6 (2):22.

Chicago/Turabian Style

Parise Adadi; Osman N. Kanwugu. 2020. "Potential Application of Tetrapleura tetraptera and Hibiscus sabdariffa (Malvaceae) in Designing Highly Flavoured and Bioactive Pito with Functional Properties." Beverages 6, no. 2: 22.

Journal article
Published: 01 September 2019 in Journal of Microbiology, Biotechnology and Food Sciences
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Parise Adadi. APPLICATION OF SURFACE RESPONSE METHODOLOGY FOR AN ENZYME-ASSISTED EXTRACTION OF CAROTENOIDS. Journal of Microbiology, Biotechnology and Food Sciences 2019, 9, 195 -203.

AMA Style

Parise Adadi. APPLICATION OF SURFACE RESPONSE METHODOLOGY FOR AN ENZYME-ASSISTED EXTRACTION OF CAROTENOIDS. Journal of Microbiology, Biotechnology and Food Sciences. 2019; 9 (2):195-203.

Chicago/Turabian Style

Parise Adadi. 2019. "APPLICATION OF SURFACE RESPONSE METHODOLOGY FOR AN ENZYME-ASSISTED EXTRACTION OF CAROTENOIDS." Journal of Microbiology, Biotechnology and Food Sciences 9, no. 2: 195-203.

Review article
Published: 05 June 2019 in Food Control
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Local Ghanaian condiments serve as a good source of protein/calories for the poor who cannot afford meat, fish, and vegetable on a regular base. Condiments are used in whole or ground form for enhancing flavor, taste, color, and appearances of food. They contain numerous essential nutrients, potent biologically active compounds, which could be useful in suppressing cancer cells from proliferating, boosting the immune system, and reducing the risk of other chronic diseases. Overwhelming evidence suggests consumers prefer these local condiments to industrially made condiments (such as bouillon cubes). These condiments are produced using crude methods (not based on standardized principles), thus making their consumption in this form less ideal. The present article provides comprehensive methods for improving the artisan methods (especially method of extraction or sample preparation) of these condiments. Techniques for the quantification of volatiles and semi-volatiles in these condiments are also discussed, together with some health concerns in relation to food safety, associated with the consumption of these condiments.

ACS Style

Parise Adadi; Nadezhda V. Barakova; Elena F. Krivoshapkina. Scientific approaches to improving artisan methods of producing local food condiments in Ghana. Food Control 2019, 106, 106682 .

AMA Style

Parise Adadi, Nadezhda V. Barakova, Elena F. Krivoshapkina. Scientific approaches to improving artisan methods of producing local food condiments in Ghana. Food Control. 2019; 106 ():106682.

Chicago/Turabian Style

Parise Adadi; Nadezhda V. Barakova; Elena F. Krivoshapkina. 2019. "Scientific approaches to improving artisan methods of producing local food condiments in Ghana." Food Control 106, no. : 106682.

Journal article
Published: 26 February 2019 in Fermentation
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Barley and other cereal grains can be used in the production of ethanol. The quality and safety of the grains utilized have enormous effects on the overall yield and quality of the final product (ethanol). Therefore, the present paper seeks to elucidate the antimicrobial activities of ultradisperse humic sapropel suspensions (UDHSS) on barley, wort, fermentation, and the quality of the final product. A standard microbiological method was used to assess the biocidal activities. Physicochemical parameters and volatile compounds were determined. Treated samples exhibited least microbial growth (for grain: 1.145 ± 0.120 × 104 cfu/g) when compared to the control (3.425 ± 0.33 × 105 cfu/g). Mash from the treated sample had less Free Amino Nitrogen (35.14 ± 0.02 mg/L) than the control experiment (41.42 ± 0.01). However, the levels of °Brix and Free Amino Nitrogen (FAN) were unaffected by the UDHSS treatments. After the chromatographic analysis, it was revealed that the barley distillate obtained from treated grains had high volatiles concentration when compared to the control experiment. The volume of the methanol quantified in the distillate was low, and hence safe, and might find applications in the food industries or in domestic consumption after rectification.

ACS Style

Daniel Nsengumuremyi; Parise Adadi; Maria V. Ukolova; Nadezhda V. Barakova. Effects of Ultradisperse Humic Sapropel Suspension on Microbial Growth and Fermentation Parameters of Barley Distillate. Fermentation 2019, 5, 24 .

AMA Style

Daniel Nsengumuremyi, Parise Adadi, Maria V. Ukolova, Nadezhda V. Barakova. Effects of Ultradisperse Humic Sapropel Suspension on Microbial Growth and Fermentation Parameters of Barley Distillate. Fermentation. 2019; 5 (1):24.

Chicago/Turabian Style

Daniel Nsengumuremyi; Parise Adadi; Maria V. Ukolova; Nadezhda V. Barakova. 2019. "Effects of Ultradisperse Humic Sapropel Suspension on Microbial Growth and Fermentation Parameters of Barley Distillate." Fermentation 5, no. 1: 24.

Journal article
Published: 01 January 2019 in Journal International Academy of Refrigeration
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Parise Adadi; D.S. Filippova; N.V. Barakova. The effect of enzyme preparations on extracting the pigments from plant raw materials. Journal International Academy of Refrigeration 2019, 1 .

AMA Style

Parise Adadi, D.S. Filippova, N.V. Barakova. The effect of enzyme preparations on extracting the pigments from plant raw materials. Journal International Academy of Refrigeration. 2019; ():1.

Chicago/Turabian Style

Parise Adadi; D.S. Filippova; N.V. Barakova. 2019. "The effect of enzyme preparations on extracting the pigments from plant raw materials." Journal International Academy of Refrigeration , no. : 1.