This study aims to identify and analyze potential tourism clusters in Romania, focusing on their geographical, cultural, and gastronomic characteristics, to highlight opportunities for sustainable regional development through integrated tourism. In conducting this research, we consulted a variety of sources, including government reports, research studies, academic articles, and information provided by local and regional authorities, which were subsequently analyzed and synthesized. The results show that, in Romania, due to its natural, cultural, and historical richness, numerous regions and areas can be considered potential tourism clusters. We identified four potential clusters: the Danube Delta Tourism Cluster, the Transylvania Tourism Cluster, the Romanian Seaside Tourism Cluster, and the Bucovina-Maramureș Tourism Cluster. Moreover, we found that each potential cluster could also be distinguished by its unique gastronomic identity. The study emphasizes the need for a strategically integrated approach to tourism development, where the gastronomic component is leveraged as a differentiating and appealing element, both on the national and international markets. The research results may serve as a helpful starting point for decision-makers, entrepreneurs, and tourism specialists interested in the sustainable and competitive development of Romania’s tourism regions.