Jelena Pilipovic Grubor

Dr. Jelena Pilipovic Grubor


Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
16 September 2026 in Diagnostics
Verified
Journal Article
Open access
PDF file
MNMarijana Basta Nikolić
Marijana Basta Nikolić
Dragan VasinDragan Vasin
Dragan Vasin
JGJelena Pilipovic Grubor
Jelena Pilipovic Grubor
MJMirela Jukovic
Mirela Jukovic
DNDijana Niciforovic
Dijana Niciforovic
SSSanja Stojanović
Sanja Stojanović
Background/Objectives: Clinical prediction models may support staged triage in acute pelvic pain, but simplified integer scores can lose information and destabilise point assignments. We evaluated a tiered clinical–ultrasound prediction pathway and the stability of its simplified score within an ultrasound-documented acute-pelvic-pain cohort. Methods: This single-centre retrospective cohort included 4800 encounters in 4320 women. Encounters from 2013 to 2019 formed the development cohort (n = 3360), and patient-separated encounters from 2020 to 2022 formed the temporal-evaluation cohort (n = 1440). M1 contained clinical and laboratory predictors without imaging variables, M2 added ultrasound descriptors, and M3 added cross-sectional-imaging descriptors. Multiple imputation, ridge logistic regression, patient-level cluster bootstrap, calibration, decision-curve analysis, reader reproducibility and score-stability analyses were used. Results: Urgent pathology occurred in 20.0% of development and 18.0% of temporal encounters. Temporal AUC was 0.841 for M1 and 0.845 for M2 (difference 0.004; 95% CI 0.001–0.009). Because inclusion required documented ultrasound, this difference estimates incremental information from the selected ultrasound descriptors within an already ultrasound-documented pathway and does not estimate the pathway-level benefit of performing ultrasound. The locked integer rule classified 2.9% as low risk, with 99.6% sensitivity and 3.5% specificity. Categorisation accounted for 0.057 of the total 0.060 AUC loss, and 798 distinct score cards arose in 800 bootstrap resamples. Conclusions: Continuous M2 retained good temporal discrimination, but the small M1-M2 difference does not establish whether ultrasound improves pathway-level triage or can safely alter subsequent management. The integer score had low rule-out yield and highly variable point assignments; independent evaluation should prioritise local calibration, clinical utility and score-card stability before implementation.