Quality of life is shaped not only by disease, symptoms, and treatment but also by the social conditions in which adults live, work, age, and manage health. This chapter examines how social determinants of health influence quality of life through structural, material, psychosocial, behavioral, and healthcare-access pathways. It distinguishes broader social determinants from individual health-related social needs and uses a life-course perspective to explain how education, employment, housing, caregiving, financial security, social relationships, discrimination, functional ability, and access to services affect well-being from young adulthood to older age. Chronic conditions illustrate the reciprocal relationship between social disadvantage and disease, including financial toxicity, treatment burden, and disruption of family and occupational roles. The chapter also considers implications for respectful social assessment, interdisciplinary care, healthcare-system adaptation, community partnerships, and policy action. Improving quality of life across adulthood requires clinically effective care to be accompanied by sustained action on the unequal distribution of resources, opportunities, and social protection.