At present, polypharmacy—which is the use of several medications to treat a single case at the same time—has become a fairly common medical practice, particularly in chronic illnesses or with older patients. But this relatively ‘faster’ form of treatment brings the problem of cumulative polypharmacy, which occurs when there is an increase in drug–drug interactions (DDIs) due to the large number of medicines taken. While the aftermath, such as the reduction in strength of medication taken or catastrophic and fatal responses to certain drugs, is clearly not worth the initial effort put into trying to ease the condition, attempting to resolve these issues requires excessive research. With these difficulties in mind, we describe our research that uses graph neural networks (GNNs) focused on DDI prediction by modeling drugs and their interactions in the form of graphs. The research is divided into two parts. In this research, the relevant literature is reviewed in order to understand how modern GNN-based algorithms can be applied for the detection of optimal drugs.

Ownership rights related to land and property represent a highly contentious matter in areas across Pakistan because female inheritors struggle to assert their property rights due to cultural practices along with unclear procedures and traditional document systems. The present government-controlled systems demonstrate inadequate proficiency along with safety protocols to execute fair inheritance distribution, mainly impacting marginalized populations. This research introduces a blockchain system known as the Land Registration and Inheritance Automation System (LRIAS) which prioritizes the female protection of inheritance privileges. The proposed system includes digitalizing the traditional paper-based land registration and inheritance process. The system ensures blockchain security through the implementation of MetaMask together with Web3.js for Ethereum transactions. The blockchain system distributes inheritances through programmed agreements which follow Shariah validation rules. The LRIAS establishes permanent and free-version records that show who owns land and who the legal heirs are. The system enables women to access their inheritance records through verifiable reliable data which cannot be altered. Through the system, authorities can verify inheritance claims and execute them without bureaucratic interference, which minimizes both legal disputes and family conflicts. Experimental tests show that the LRIAS succeeds in safeguarding women’s land inheritance claims and increasing confidence in legal inheritance procedures.

For organizations, protecting computer networks has always been a very tough and demanding task. In the current technological era digital resources can now be protected without the need for outdated traditional perimeter-based security techniques. Organizations can use the Zero Trust Network Access (ZTNA) approach to safeguard and filter their vital digital assets for the company’s benefit. This platform uses sophisticated logical authentication to test the system’s ability to authenticate users, and network monitoring is used to look for possible security flaws and system vulnerabilities. By evaluating users’ interactions with the system and their handling of assigned digital resources, multi-factor authentication filters out unwanted access attempts. Three fundamental access control styles are provided by network segmentation, giving administrators the option to manage access in a democratic, strict, or flexible manner (least privilege approach).