As a common mental disorder, depression is one of the leading causes of disability around the world. Clinical studies have shown that acupuncture is an effective therapy without obvious side effects compared to limited efficacy and adverse reactions of drug therapy, cognitive behavioral therapy, and neuromodulation technology in treating depression. The objective of this review is to systematically evaluate whether acupuncture therapies for depression are safe and effective in order to provide a high‐quality reference for clinical trials of acupuncture. A systematic search of the literature was carried out through bibliographic search engine PubMed. Subsequently, the study design, intervention methods, control group, results, and safety of acupuncture were analyzed. The results showed that acupuncture as an adjunct to antidepressants or as a single treatment can exert a positive impact on patients' depressive symptoms. Compared with antidepressants, acupuncture has the advantages of fast onset and long‐term efficacy in the treatment of depression, and can enhance the efficacy of antidepressants. Moreover, the efficacy and safety of acupuncture in the treatment of depression maybe related to the qualification of the acupuncturist, the selection of acupoints, and intervention measures.

Objective: Keratosis pilaris (KP) is a common follicular keratotic skin disorder characterized by follicular papules and skin roughness, often accompanied by itching and inflammation, significantly affecting appearance and psychological health. Methods: This 28‐day prospective, open‐label, randomized controlled study evaluated the effectiveness of a novel combined formula for KP treatment. The formula included a scrub ( Olea europaea shell powder, hydrated silica, and papain) and a moisturizing lotion with plant oils (peony seed oil, oat kernel oil, and rice bran oil). Sixty KP patients aged 18–35 were randomly assigned to a control group (salicylic acid body lotion) or a study group (combined formula), with 30 participants each. Evaluations included follicular papule counts, transepidermal water loss (TEWL), and depression scale scores at baseline (D0), day 7 (D7), day 14 (D14), day 21 (D21), and day 28 (D28). After D28, a self‐assessment questionnaire was used to compare treatment outcomes. Results: According to the repeated‐measures ANOVA, the control and study group had a significant reduction in follicular papule counts over time (all p < 0.05). For TEWL values, a significant simple effect of time was observed in the study group ( p = 0.026), whereas the control group showed only a marginal change ( p = 0.054). Despite the absence of a significant main group effect ( p = 0.287), these results suggest that the study group achieved a greater overall improvement in skin barrier function over time. In the self‐assessment, 21 out of 23 indicators had higher effectiveness rates in the study group than the control group, with 96.7% effectiveness in improving skin dryness, smoothness, roughness, freshness, oiliness, and oil control. Depression scale scores were significantly affected by both time and group ( p = 0.017 and p = 0.008, respectively), indicating psychological improvement after 28 days. Conclusion: The combined formula effectively reduced follicular papules, improved skin hydration, decreased TEWL, and alleviated depressive symptoms in KP patients.