Triphala is a traditional three‐fruit formulation with potential anticancer activity, but its ferroptosis‐related mechanisms in oral cancer remain unclear. We integrated network pharmacology, transcriptomic analyses, prognostic modeling, Mendelian randomization, immune and drug‐response analyses, molecular docking, and in vitro validation to investigate the Triphala–ferroptosis–oral cancer axis. Fifty‐eight candidate functional genes were identified, and an eight‐gene signature comprising AKR1C3, CA9, EGFR, GSTA1, MAPK8, MGST1, PPARG, and RB1 showed prognostic value across multiple cohorts. Mendelian randomization supported causal associations of MAPK8, MGST1, and PPARG with oral cancer risk. Seven Triphala‐derived compounds, including epigallocatechin gallate, quercetin, kaempferol, luteolin, ellagic acid, gallic acid, and quinine, displayed favorable predicted interactions with key targets. In CAL‐27 cells, Triphala altered the expression of signature genes, reduced GPX4 and SLC7A11 protein levels, increased Fe ²⁺ and malondialdehyde, depleted glutathione and glutathione peroxidase activity, and enhanced lipid peroxidation; these effects were partially modulated by ferrostatin‐1. This study advances the field by linking Triphala to a ferroptosis‐based prognostic framework and experimentally demonstrating its regulation of the SLC7A11–GSH–GPX4 axis in oral cancer.

Background: Triphala, a traditional Ayurvedic formulation, has garnered significant research interest for its diverse therapeutic potential. However, a comprehensive analysis of its research landscape remains limited. Objective: To conduct a comprehensive bibliometric analysis of Triphala research from 2000 to 2024, examining publication trends, research hotspots, and evolving research themes. Methods: Publications related to Triphala were retrieved from the Web of Science core collection database (2000–2024). Bibliometric analysis utilized CiteSpace and VOSviewer to analyze publication trends, collaboration networks, and research hotspots. Visualization tools mapped the temporal evolution of research themes and collaboration patterns. Results: The analysis of 417 publications unveiled a complex landscape of research development, identifying 5 major research themes that progressively evolved from 2006 to 2024, including apoptosis, radiation effects, oxidative stress, oral therapeutics, and molecular docking studies. Each theme demonstrated varying research strengths, with oral therapeutics showing the highest research intensity at strength = 3.1. Geographically, the research was predominantly concentrated in India, which produced 271 publications, significantly outpacing the United States (34 publications) and China (33 publications). The research was primarily disseminated through specialized journals, with the International Journal of Ayurvedic Medicine, Journal of Ayurveda and Integrative Medicine, and Indian Journal of Traditional Knowledge emerging as the most influential publication platforms. Key research institutions, including the Bhabha Atomic Research Centre, Chiang Mai University, and Mahidol University, played pivotal roles in advancing Triphala research. Conclusion: This bibliometric analysis demonstrates the progressive evolution of Triphala research from traditional applications to sophisticated scientific investigations. The study reveals a significant transformation in research focus, transitioning from basic mechanistic studies to advanced molecular investigations and clinical applications, particularly in oral health.

The specific role of visceral adiposity in dental caries risk remains underexplored. This study investigated the association between visceral adiposity ind

Background: Oral health-related quality of life (OHRQoL) serves as a key measure for understanding how systemic health conditions affect oral health and daily functioning. This study aims to systematically analyze the research on the relationship between OHRQoL and systemic diseases using scientometric methods, with the goal of uncovering research trends, hotspots, and frontiers. Methods: Publications from the Web of Science were analyzed using GraphPad Prism, Bibliometrix, VOSviewer, and CiteSpace. Results were visualized. Results: A total of 441 documents (2001–2024) were included. Publication output steadily increased, with a surge in 2020. Core authors, journals, and institutions were mainly from developed countries. Frequent keywords included “OHRQoL,” “oral health,” “impact,” “validation,” and “periodontal disease.” Twelve keyword clusters were identified: “oral cancer,” “oral squamous cell carcinoma,” “breast neoplasms,” “oral health,” and “dental care” were key hotspots. “Osteoporosis” and “benign mucous membrane” emerged as novel themes, while “consensus,” “older people,” “2017 World Workshop,” and “dry mouth” showed strong bursts. Conclusions: Research has advanced significantly, with developed countries as key contributors. Cancer, periodontitis, and the validation tools are central topics. Aging populations, and systemic or oral diseases in older adults are expected to shape future directions.

Background: Dental education is comprehensive and challenging because it requires both appropriate theoretical and practical competencies. Various teaching formats and strategies are discussed in the literature, yet a comprehensive, model-based understanding of sustainable dental education remains lacking. Main body: This narrative review discusses different factors affecting academic success in overall and dental education. Thereby, a conceptual, non-systematic literature search and subsequent synthesis is provided. Driven by the available literature, motivation, student–teacher relationship (STR), expectations on results, and self-efficacy are interpreted as relevant factors, together with a contemporary teaching philosophy with a hybrid role of the teacher between mentor and coach. On this basis, a hypothetic framework is developed and discussed regarding current teaching formats in dental education, including problem-based learning (PBL), communication and self-reflection skills, practical training, and integrative teaching. Against this background, the limitations of the applied conceptual framework and implications for increasing the body of evidence are also discussed. Conclusions: Dental (and overall higher) education is complex and affected by various superordinate parameters. Student-centered education might consider motivation, self-efficacy and STR, together with teaching philosophy, the academic environment as well as the interrelation between theory and practice. These factors are relevant outcomes for future research in dental education, for which standardized and validated instruments should be elaborated and used. Overall, the conceptual framework is limited by its methodology, generalizability and model selection, requiring further research in the field.