Saritas AG, et al. Ann Surg Treat Res. 2020 Oct;99(4):230-237. https://doi.org/10.4174/astr.2020.99.4.230

Background and Objectives: Systemic inflammation, nutritional status, and host immune response play pivotal roles in cancer progression and patient prognosis. The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel inflammation-based biomarker integrating these parameters. This study aimed to evaluate the prognostic value of the preoperative CALLY index in patients undergoing pancreaticoduodenectomy for pancreatic head adenocarcinoma. Materials and Methods: This retrospective study included 101 consecutive patients who underwent pancreaticoduodenectomy with curative intent for histopathologically confirmed pancreatic head adenocarcinoma at Çukurova University Faculty of Medicine between 2010 and 2021. Demographic, clinicopathological, perioperative, and survival data were analyzed. The CALLY index was calculated using preoperative serum C-reactive protein, albumin, and lymphocyte levels, and the optimal cutoff value was determined by receiver operating characteristic (ROC) curve analysis. Results: Using an optimal cutoff value of 1.38, patients were categorized into low (n = 58) and high (n = 43) CALLY index groups. Patients with a low CALLY index experienced significantly higher rates of intraoperative and postoperative complications, surgical site infection, reoperation, unplanned hospital readmissions, and 30- and 90-day mortality (all p < 0.05). Moreover, the low CALLY index group demonstrated significantly poorer overall survival than the high CALLY index group (p < 0.001). Receiver operating characteristic (ROC) analysis for overall mortality yielded an area under the curve (AUC) of 0.701 (95% CI, 0.591–0.811). On multivariable Cox regression, a low CALLY index remained an independent predictor of poorer overall survival (adjusted hazard ratio [aHR], 2.45; 95% CI, 1.47–4.08; p < 0.001) after adjustment for age, tumor size, lymph node status, resection margin, and differentiation. On multivariable logistic regression, a low CALLY index was independently associated with surgical site infection (adjusted odds ratio [aOR], 11.5; 95% CI, 3.9–34.2; p < 0.001) and overall postoperative morbidity (aOR, 5.3; 95% CI, 2.0–14.0; p < 0.001). Conclusions: The preoperative C-reactive protein–albumin–lymphocyte (CALLY) index is a simple, inexpensive, and readily available biomarker with significant prognostic value in patients undergoing pancreaticoduodenectomy for pancreatic head adenocarcinoma. A low CALLY index was associated with poorer overall survival and increased postoperative morbidity and mortality. The CALLY index may serve as a practical tool for preoperative risk stratification and prognostic assessment. However, prospective multicenter studies are warranted to validate standardized cutoff values and further establish its clinical applicability.

Amaç: Bu çalışmada elektif splenektomi uygulanan olgularda Açık Splenektomi (AS) ile Laparoskopik Splenektominin (LS) karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamıza Çukurova Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı’nda 1 Ocak 2013- 1 Ocak 2018 tarihleri arasında elektif splenektomi ameliyatı yapılan 95 hasta dahil edildi. Hastaların demografik bilgileri etyolojik neden, ameliyat süresi, kan kaybı miktarı, preoperatif dönemde dalak boyut ölçümü yapıldı. Laparoskopik cerrahiden açık cerrahiye geçme zorunluluğu, hastanede yatış süresi, postoperatif kan ürünleri replasmanı ve postoperatif gelişen komplikasyonlar incelendi.Bulgular: Çalışmamıza dahil edilen hastaların %79‘una (n=75) açık splenektomi, % 21 ‘ine (n=20) laparaskopik splenektomi olmak üzere toplam 95 olgu dahil edildi. Çalışmaya alınan olgularda ortalama yaş AS’ de 43.0±17 (18-78), LS’ de ise 39.3±13.9 idi (19-62). AS uygulanan olguların 31 tanesi erkek (% 41.3), 44 tanesi ise kadın (%58.7) cinsiyette idi. LS uygulanan olguların 7 tanesi erkek (%35), 13 tanesi ise kadın cinsiyette (%65) idi. AS uygulanan 75 olgudan 19 (% 25.3) olgu splenomegali, 16 (% 21.3) olgu immün trombositopenik purpura (ITP), 11(% 14.7) olgu kitle,7 (% 9.3) olgu ise Talasemi nedeniyle opere edildi.LS uygulanan 20 olgudan 12 (% 60) olgu ITP, 3 (% 15) olgu Hemolitik anemi, 2 (% 10) olgu ise lenfoma nedeniyle opere edildi. LS’de yatış süresi, kanama miktarı ve dalak boyutu üstün iken; AS’de ameliyat süresi anlamlı derecede üstün bulundu .Sonuç: Komplikasyon oranı, hastanede yatış süresi ve maliyetinin daha az olması nedeni ile LS, OS’ye göre daha güçlü bir alternatiftir.

Aim: The aim of this study was to adapt and validate the Cryptoglandular Anal Fistula Quality of Life (AF-QoL) scale for Turkish-speaking patients, providing a disease-specific, patient-reported outcome measure (PROM) to assess quality of life (QoL) in cryptoglandular anal fistula. Methods: A prospective, multicenter, cross-sectional study was conducted across seven tertiary centers in Türkiye. The 22-item AF-QoL scale, originally validated in English, was translated and culturally adapted into Turkish following Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines, including expert consensus and a pilot study ( n = 10). A total of 220 Turkish-speaking adults with cryptoglandular anal fistula completed the scale. Structural validity was evaluated using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Internal consistency was assessed using Cronbach’s alpha, and item–total correlations. Test–retest reliability was evaluated in a clinically stable subgroup of patients. Results: EFA confirmed a six-domain structure, comprising psychological impact, everyday activities, unpredictability/disease control, seton-related issues, social limitations, and discharge/discomfort, explaining 69.2% of the total variance. CFA demonstrated an acceptable overall model fit ( χ ² / df = 1.94, root mean square error of approximation [RMSEA] = 0.048, Comparative Fit Index [CFI] = 0.945, standardized root mean square residual [SRMR] = 0.035). The Turkish AF-QoL demonstrated high internal consistency (Cronbach’s α = 0.828), satisfactory item–total correlations ( r = 0.32–0.76), and good test–retest reliability (intraclass correlation coefficient = 0.74), indicating temporal stability. Conclusions: The Turkish version of the AF-QoL demonstrates satisfactory reliability and structural validity for use in Turkish patients with cryptoglandular anal fistula. This cross-cultural validation provides a disease-specific PROM suitable for clinical and research applications. Further studies assessing additional measurement properties, including structural validity, measurement error, and responsiveness, are warranted. Clinical trial registration: This study was not a clinical trial and thus was not registered in a clinical trial registry.

Introduction: Carcinoembryonic antigen(CEA) serves as a biomarker for gastrointestinal cancers, with high levels often indicating a poor prognosis. Specifically, CEA levels above 10 µg/L are associated with unfavorable outcomes, and those exceeding 20 µg/L are linked to metastatic disease. This investigation aims to explore the relationship between elevated preoperative CEA levels and the survival and prognosis of colon cancer patients at our institution. Materials and Methods: This study was designed as a single-center, retrospective analysis involving colon cancer patients who underwent surgery at *** from 2012 to 2022. Patients were stratified based on preoperative CEA levels into three groups: 3-10 µg/L (low-high), 10-20 µg/L (moderately high), and over 20 µg/L (very high). The study compared demographic data, pathological features, and survival outcomes across these groups. Results: The study included 226 patients, 124 males and 102 females, with an average age of 61 years. Analysis revealed no significant difference in TNM and pathological stages among the groups. Notably, higher CEA levels were significantly correlated with increased instances of venous, perineural and lymphatic invasion. The occurrence of local, para-aortic, and peritoneal recurrences did not significantly differ across the groups, although liver metastasis was more prevalent in the first group. Discussion: The findings highlight a significant link between high preoperative CEA levels and an increased risk of lymphovascular and perineural invasion in colon cancer patients. This association underscores the potential for tailoring more intensive treatment regimens for patients with elevated CEA levels,including the possibility of enhanced chemotherapy or radiotherapy.