Seromucinous hamartoma is a rare benign glandular proliferation arising from the respiratory epithelium of the sinonasal tract and nasopharynx. It was described for the first time in 1974 by Baillie and Batsakis. Since then, few cases have been reported in the literature with most of them occurring in the posterior nasal septum. We report the case of a 52-year-old woman that presented to our department with left periorbital edema, pain, and dacryorrhea due to seromucinous hamartoma arising from the left inferior turbinate and extending through the lateral nasal wall into the maxilla, the nasolacrimal duct, and the orbit. Endoscopic medial maxillectomy and endoscopic transnasal orbital tumor resection were performed. The patient remains symptom-free for 16 months, till her most recent follow-up. Seromucinous hamartoma of the nasal cavity is an exceedingly rare diagnosis, especially in the lateral nasal wall. It should be included in the differential diagnosis of nasal tumors. According to the literature review, this is the first case report of seromucinous hamartoma with orbit infiltration. Endonasal endoscopic resection is the treatment of choice.

Primary parapharyngeal space tumors are rare, and due to the complex anatomy of the parapharyngeal space, their diagnosis and treatment are challenging. Pleomorphic adenoma is the most common histologic type followed by paragangliomas and neurogenic tumors. They can present as a neck lump or an intraoral submucosal mass with the displacement of the ipsilateral tonsil or might be asymptomatic and discovered incidentally on imaging obtained for other reasons. Magnetic resonance imaging (MRI) with gadolinium is the imaging of choice. Surgery remains the treatment of choice and many approaches have been described. In this study, we present three patients with PPS pleomorphic adenoma (two primary and one recurrent), which were resected successfully with a transcervical-transparotid approach without mandibulotomy. Division of the following anatomical structures: the posterior belly of the digastric muscle, stylomandibular ligament, stylohyoid muscle and ligament, and styloglossus muscle is a very important tip for the surgeons because enables displacement of the mandible providing excellent exposure for complete tumor excision. The only postoperative complication was temporary facial nerve palsy in two patients who fully recovered within two months. The aim of this mini case series is to present our experience, together with some tips and benefits of the transcervical-transparotid approach for the resection of pleomorphic adenomas of the PPS.

In this paper, we present the case of acute airway obstruction due to tracheal carcinoma in a patient with glottic stenosis due to previously treated laryngeal carcinoma. Because of severe dyspnea from the obstructive endotracheal mass, tracheotomy under local anesthesia was immediately performed. Intubation with pediatric size (I.D. 4.5 mm) cuffed endotracheal tube was performed by the surgeon through tracheostomy under endoscopic visualization. Blakesley forceps and electrocautery were used for tumor debulking. Postoperatively there were no complications and the patient was discharged after four days. The histopathology report showed a squamous cell carcinoma. The tumor board decided on adjuvant chemoradiotherapy for the treatment of the patient.

Pyogenic granuloma is a benign proliferative fibrovascular lesion commonly arising from the skin and mucous membranes of the head and neck region. Histologically, this tumor is characterized by vascular proliferation and a circumscribed group of capillaries organized in lobules. It is usually located in the oral cavity and nasal location is less frequent. When it occurs in pregnant women, it is usually referred as pyogenic granuloma gravidarum. In this article we present the case of a pyogenic granuloma gravidarum in a young woman with intermittent epistaxis during the last trimester of pregnancy that did not resolve after childbirth and was treated with transnasal endoscopic resection and cautery at the base of the lesion for hemostasis under local anesthesia.

Background: Near-infrared autofluorescence (NIRAF) imaging has been widely used to identify parathyroid glands, but its impact on postoperative hypoparathyroidism and hypocalcemia remains controversial. This systematic review aims to evaluate the impact of NIRAF on postoperative hypoparathyroidism and hypocalcemia rates compared to conventional thyroid surgery. Methods: This study was conducted in accordance with PRISMA 2020 guidelines. We conducted a systematic search across PubMed, Scopus, and Google Scholar from January 2011 to April 2026. Studies comparing postoperative calcium and parathyroid hormone (PTH) levels, hypoparathyroidism and hypocalcemia rates, parathyroid gland identification rates, and inadvertent parathyroid gland resection rates between NIRAF and conventional surgery were included. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool for randomized controlled studies and the ROBINS-I tool for non-randomized studies (cohort, case–control, before-and-after, and retrospective analyses). We performed a narrative synthesis of the results following the Synthesis Without Meta-analysis (SWiM) reporting guidelines, due to profound diagnostic and threshold heterogeneity across studies. Results: Seventeen studies, including a total of 5163 patients (control = 3397, NIRAF = 1766), with a sample size-weighted mean age of 51.19 years, met the selection criteria and were included in the systematic review. The most common surgical procedure was total thyroidectomy without central neck dissection (ten out of seventeen studies, 58.8%). Regarding the NIRAF device, Fluobeam was the most used among the included studies (64.71%). Across 16 studies evaluating postoperative hypocalcemia, point estimates consistently favored the NIRAF intervention across varying sample sizes, showing a clear directional trend toward reducing transient postoperative hypocalcemia, even when small-sample studies lacked the power to reach statistical significance. Regarding postoperative hypoparathyroidism, the synthesis showed that NIRAF’s clinical utility depends directly on the extent of surgical dissection, providing a major protective effect size when central neck dissection is performed. Conclusions: This systematic review indicates that NIRAF provides protective effects against transient postoperative hypocalcemia and temporary hypoparathyroidism, especially when central neck dissection is performed. NIRAF also significantly increases per-gland parathyroid identification rates and reduces incidental parathyroidectomy. According to this review, NIRAF exerts no significant effects on permanent hypoparathyroidism or permanent hypocalcemia rates. Broad clinical generalization remains limited by the profound heterogeneity in diagnostic thresholds and metrics across the literature.