We propose a crossover-based adaptive local search (LS) operation for enhancing the performance of standard differential evolution (DE) algorithm. Incorporating LS heuristics is often very useful in designing an effective evolutionary algorithm for global optimization. However, determining a single LS length that can serve for a wide range of problems is a critical issue. We present a LS technique to solve this problem by adaptively adjusting the length of the search, using a hill-climbing heuristic. The emphasis of this paper is to demonstrate how this LS scheme can improve the performance of DE. Experimenting with a wide range of benchmark functions, we show that the proposed new version of DE, with the adaptive LS, performs better, or at least comparably, to classic DE algorithm. Performance comparisons with other LS heuristics and with some other well-known evolutionary algorithms from literature are also presented.

We present a memetic algorithm for evolving the structure of biomolecular interactions and inferring the effective kinetic parameters from the time-series data of gene expression using the decoupled S-system formalism. We propose an Information Criteria-based fitness evaluation for gene network model selection instead of the conventional Mean Squared Error (MSE)-based fitness evaluation. A hill-climbing local-search method has been incorporated in our evolutionary algorithm for efficiently attaining the skeletal architecture that is most frequently observed in biological networks. The suitability of the method is tested in gene circuit reconstruction experiments, varying the network dimension and/or characteristics, the amount of gene expression data used for inference, and the noise level present in expression profiles. The reconstruction method inferred the network topology and the regulatory parameters with high accuracy. Nevertheless, the performance is limited to the amount of expression data used and the noise level present in the data. The proposed fitness function has been found to be more suitable for identifying the correct network topology and for estimating the accurate parameter values compared to the existing ones. Finally, we applied the methodology for analyzing the cell-cycle gene expression data of budding yeast and reconstructed the network of some key regulators.

Most of the existing in silico phosphorylation site prediction systems use machine learning approach that requires preparing a good set of classification data in order to build the classification knowledge. Furthermore, phosphorylation is catalyzed by kinase enzymes and hence the kinase information of the phosphorylated sites has been used as major classification data in most of the existing systems. Since the number of kinase annotations in protein sequences is far less than that of the proteins being sequenced to date, the prediction systems that use the information found from the small clique of kinase annotated proteins can not be considered as completely perfect for predicting outside the clique. Hence the systems are certainly not generalized. In this paper, a novel generalized prediction system, PPRED (Phosphorylation PREDictor) is proposed that ignores the kinase information and only uses the evolutionary information of proteins for classifying phosphorylation sites.

Classification of datasets with imbalanced sample distributions has always been a challenge. In general, a popular approach for enhancing classification performance is the construction of an ensemble of classifiers. However, the performance of an ensemble is dependent on the choice of constituent base classifiers. Therefore, we propose a genetic algorithm-based search method for finding the optimum combination from a pool of base classifiers to form a heterogeneous ensemble. The algorithm, called GA-EoC, utilises 10 fold-cross validation on training data for evaluating the quality of each candidate ensembles. In order to combine the base classifiers decision into ensemble’s output, we used the simple and widely used majority voting approach. The proposed algorithm, along with the random sub-sampling approach to balance the class distribution, has been used for classifying class-imbalanced datasets. Additionally, if a feature set was not available, we used the (α, β) − k Feature Set method to select a better subset of features for classification. We have tested GA-EoC with three benchmarking datasets from the UCI-Machine Learning repository, one Alzheimer’s disease dataset and a subset of the PubFig database of Columbia University. In general, the performance of the proposed method on the chosen datasets is robust and better than that of the constituent base classifiers and many other well-known ensembles. Based on our empirical study we claim that a genetic algorithm is a superior and reliable approach to heterogeneous ensemble construction and we expect that the proposed GA-EoC would perform consistently in other cases.