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Xin Huang
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, Ministry of Education, China Agricultural University, Beijing 100083, China

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Review
Published: 01 May 2021 in Nutrients
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Selenium (Se) is an essential element for the maintenance of a healthy physiological state. However, due to environmental and dietary factors and the narrow safety range of Se, diseases caused by Se deficiency or excess have gained considerable traction in recent years. In particular, links have been identified between low Se status, cognitive decline, immune disorders, and increased mortality, whereas excess Se increases metabolic risk. Considerable evidence has suggested microRNAs (miRNAs) regulate interactions between the environment (including the diet) and genes, and play important roles in several diseases, including cancer. MiRNAs target messenger RNAs to induce changes in proteins including selenoprotein expression, ultimately generating disease. While a plethora of data exists on the epigenetic regulation of other dietary factors, nutrient Se epigenetics and especially miRNA regulated mechanisms remain unclear. Thus, this review mainly focuses on Se metabolism, pathogenic mechanisms, and miRNAs as key regulatory factors in Se-related diseases. Finally, we attempt to clarify the regulatory mechanisms underpinning Se, miRNAs, selenoproteins, and Se-related diseases.

ACS Style

Xin Huang; Yu-Lan Dong; Tong Li; Wei Xiong; Xu Zhang; Peng-Jie Wang; Jia-Qiang Huang. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients 2021, 13, 1527 .

AMA Style

Xin Huang, Yu-Lan Dong, Tong Li, Wei Xiong, Xu Zhang, Peng-Jie Wang, Jia-Qiang Huang. Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress. Nutrients. 2021; 13 (5):1527.

Chicago/Turabian Style

Xin Huang; Yu-Lan Dong; Tong Li; Wei Xiong; Xu Zhang; Peng-Jie Wang; Jia-Qiang Huang. 2021. "Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress." Nutrients 13, no. 5: 1527.

Journal article
Published: 23 February 2019 in Toxins
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Aflatoxin M1 (AFM1) and ochratoxin A (OTA), which widely coexist in milk, may pose a serious threat to human health. Mucin is a major component of the intestinal mucus layer, which plays an important role in maintaining intestinal mucosal homeostasis. However, the effect of mycotoxins AFM1 and OTA on intestinal mucin production is still not clear. This study aimed to investigate individual and interactive effects of mycotoxins AFM1 and OTA on the intestinal barrier and the mRNA expression of intestinal mucin (MUC2, MUC5AC and MUC5B) and on protein production in Caco-2/HT29-MTX cultures after 48 h of exposure. Our results show that individual mycotoxins and their mixtures significantly reduced intestinal cell viability and transepithelial electrical resistance (TEER) values, as well as significantly altered intestinal mucin mRNA expression and protein abundance. Moreover, OTA showed toxicity similar to AFM1 in cell viability and TEER value at the same concentration. When the two mycotoxins acted in combination, the synergistic effects observed in the assessment of cell viability and protein abundance in all mono- and co-cultures. In general, this study provides evidence that AFM1 and OTA can damage the intestine, and it contributes to optimized maximum permissible limits of mycotoxins in milk.

ACS Style

Xin Huang; Yanan Gao; Songli Li; Chenqing Wu; Jiaqi Wang; Nan Zheng. Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-Cultures Following Exposure to Individual and Combined Aflatoxin M1 and Ochratoxin A. Toxins 2019, 11, 132 .

AMA Style

Xin Huang, Yanan Gao, Songli Li, Chenqing Wu, Jiaqi Wang, Nan Zheng. Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-Cultures Following Exposure to Individual and Combined Aflatoxin M1 and Ochratoxin A. Toxins. 2019; 11 (2):132.

Chicago/Turabian Style

Xin Huang; Yanan Gao; Songli Li; Chenqing Wu; Jiaqi Wang; Nan Zheng. 2019. "Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-Cultures Following Exposure to Individual and Combined Aflatoxin M1 and Ochratoxin A." Toxins 11, no. 2: 132.