This study was standardized to investigate the effects of trace metals in smokers’ blood samples and find metals’ correlation with virulent diseases. An auxiliary finding was used to detect the inflated amount of metal absorption, which was determined by Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The large metal level does not generate immunity in the smoker’s body. Human samples display fickle computation of concentrations of these metals. The Mean±SD of As, B, Pb Sr, and Zn in smoker’s samples were (6.1±2.9 ppb), (285.9±118.1 ppb), (60.7±28.5 ppb), (28.6±9.8 ppb), and (420.5±100.4 ppb) reciprocally. The As, B, Pb, Sr, and Zn concentrations in all the smokers’ blood samples were over the acceptable limit, withal the P-value= (≥0.05) all the samples have displayed no correlation in smokers against viral inflammation. This examination can be used as a support and quotation for further investigations. These findings declare that the number of metals in the body for long periods contributes to toxicity and promotes viral infections.