Children experiencing parental maltreatment face dual harm due to frequent stressful interactions with their family
1 and lack of access to the stress-reducing benefits of high-quality parental care.
2 Thus, exposure to parental maltreatment can disrupt normative developmental processes and is a major risk factor for psychological and physical health problems.
1,3 Chronic activation of physiological stress systems, such as the hypothalamic-pituitary-adrenal (HPA) axis, is considered one of the mediating mechanisms for the unfolding of some of these disease processes.
4 Indeed, there is accumulating evidence that HPA axis functioning is altered in children experiencing adverse care.
5-9 Disrupted patterns of HPA activity are associated with numerous behavioral and emotional problems in children, including both internalizing and externalizing symptoms.
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