Living Labs for Sustainable Development aim to integrate users and actors for the successful generation of low-resource innovations in production-consumption systems. This paper investigates potentials of and measures towards the realization of a German Living Lab infrastructure to support actor-integrated sustainability research and innovations in Germany. Information was primarily derived from extensive dialog with experts from the fields of innovation, sustainable development and the Living Lab community (operators, users, etc.), which was facilitated through interviews and workshops. A status quo analysis revealed that, generally, the sustainability and Living Lab communities are hardly intertwined. Twelve Living Labs that explicitly consider sustainability aspects were identified. The application fields “Living and Working”, “Town, Region and Mobility”, and “Retail and Gastronomy” were identified as particularly suitable for investigation in Living Labs and highly relevant in terms of resource efficiency. Based on the analyses of drivers and barriers and SWOT, keystones for the development of a research infrastructure for user integrated development of sustainable products and services were formulated. Suggested strategies and measures include targeted funding programs for actor-integrated, socio-technical research based on a Living Lab network, a communication campaign, and programs to foster networking and the inclusion of SMEs.