It has been recognised with growing concern that agricultural and industrial wastes are increasingly produced in large volume. In order to reduce environmental hazards and conserve natural resources, the use of waste materials in highway pavements would be extremely effective in terms of recycling waste materials. The main purpose of this study was to investigate the effects of waste materials as filler on the performance of hot mix asphalt (HMA) mixtures. HMA mixtures containing waste glass powder (WGP), waste brick powder (WBP), rice husk ash (RHA) and stone dust (control mixture) were fabricated and the optimum asphalt binder content was determined for each mixture. The properties of HMA mixtures were investigated by Marshall, indirect tensile stiffness modulus and indirect tensile fatigue tests. The results indicated that WGP and WBP mixtures exhibited higher fatigue life and better performance than other mixtures. In addition, it was determined that there was no considerable difference in the performance of RHA mixture and control mixture.