Paula Zapata

Prof. Dr. Paula Zapata

Universidad de Santiago de Chile
+1
orcid

Research Focus & Metrics

Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 January 2017 in Applied Sciences
Verified
Journal Article
Open access
PDF file
ALAndrea León
Andrea León
PRPatricia Reuquen
Patricia Reuquen
CGCarolina Garín
Carolina Garín
RSRodrigo Segura
Rodrigo Segura
Patricio VargasPatricio Vargas
Patricio Vargas
POPedro Orihuela
Pedro Orihuela
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery.

1 July 2014 in Materials Science and Engineering: C
Verified
Journal Article
Closed access
LTLaura Tamayo
Laura Tamayo
PZPaula Zapata
Paula Zapata
NVN.D. Vejar
N.D. Vejar
MAM.I. Azócar
M.I. Azócar
MGM.A. Gulppi
M.A. Gulppi
MPM.A. Páez
M.A. Páez

16 January 2019 in Materials
Verified
Journal Article
Open access
PDF file
HPHumberto Palza
Humberto Palza
PZPaula Zapata
Paula Zapata
CACarolina Angulo-Pineda
Carolina Angulo-Pineda
The flexibility in polymer properties has allowed the development of a broad range of materials with electroactivity, such as intrinsically conductive conjugated polymers, percolated conductive composites, and ionic conductive hydrogels. These smart electroactive polymers can be designed to respond rationally under an electric stimulus, triggering outstanding properties suitable for biomedical applications. This review presents a general overview of the potential applications of these electroactive smart polymers in the field of tissue engineering and biomaterials. In particular, details about the ability of these electroactive polymers to: (1) stimulate cells in the context of tissue engineering by providing electrical current; (2) mimic muscles by converting electric energy into mechanical energy through an electromechanical response; (3) deliver drugs by changing their internal configuration under an electrical stimulus; and (4) have antimicrobial behavior due to the conduction of electricity, are discussed.

1 December 2015 in Materials Science and Engineering: C
Verified
Journal Article
Closed access
CFCarmen Fonseca
Carmen Fonseca
AOAlmudena Ochoa
Almudena Ochoa
MUMaria Teresa Ulloa
Maria Teresa Ulloa
Eduardo Alvarez-DuarteEduardo Alvarez-Duarte
Eduardo Alvarez-Duarte
DCDaniel Canales
Daniel Canales
PZPaula Zapata
Paula Zapata

1 August 2011 in European Polymer Journal
Verified
Journal Article
Closed access
PZPaula Zapata
Paula Zapata
LTLaura Tamayo
Laura Tamayo
MPMaritza Páez
Maritza Páez
ECEnrique Cerda
Enrique Cerda
IAIgnacio Azócar
Ignacio Azócar
FRFranco M. Rabagliati
Franco M. Rabagliati

1 September 2019 in Composites Part B: Engineering
Verified
Journal Article
Closed access
KRKarina Rojas
Karina Rojas
DCDaniel Canales
Daniel Canales
NANicolas Amigo
Nicolas Amigo
LMLissette Montoille
Lissette Montoille
ACAlejandro Cament
Alejandro Cament
PZPaula Zapata
Paula Zapata