This study investigated the anti-inflammatory effects of Rubus parvifolius leaf (RPL) extract, and its phytochemical composition was characterized using LC-MS/MS and HPLC analyses. In an inflammation model using HaCaT keratinocytes, treatment with RPL extract led to a significant reduction in inflammatory markers, indicating strong anti-inflammatory activity. Phytochemical analysis revealed that the extract is rich in flavonoids, with quercetin 3,7-diglucoside (12.73 mg/g DW) as the most abundant compound, followed by hirsutrin (4.74 mg/g DW) and ellagic acid (1.58 mg/g DW). Kaempferol 3-O-glucuronide was detected in lower amounts (0.31 mg/g DW), and tiliroside was present only in trace levels. These compounds are well known for their antioxidant and anti-inflammatory properties, suggesting that RPL extract may exert multiple beneficial effects on skin health. Collectively, these findings support the potential of RPL extract as a natural therapeutic agent for managing skin inflammation, particularly in conditions such as atopic dermatitis, with its efficacy likely attributed to the high levels of quercetin 3,7-diglucoside, hirsutrin, and ellagic acid. However, the present work was confined to in vitro experiments, and the mechanistic pathways were not experimentally validated. Future in vivo studies are needed to confirm these findings.
Ecological impacts. Furthermore, based on specimen data, the spread level of each taxon was assessed: 117 taxa were classified with a spread level of "notable spread" (NS) or higher. Although most alien plants in the Republic of Korea are currently not invasive, this status may change in the future due to climate change or ongoing human disturbances. Therefore, continuous research and the establishment of management measures to prepare for their potential invasiveness are necessary.
31 January 2018 in International Journal of Control and Automation
기후적응을 위해 산림부문에서 풀어가야 할 핵심과제는 산림정책에 기후적응을 주류화하고, 적응 조치의 효과성 모니터링 및 평가를 포함하는 적응의 선순환 체계를 정립하는 것이다. 우리나라 산림의 장기적인 관리 계획의 기본 방향을 제시해주는 것은 산림청이 산림기본법 제11조 및 같은 법 시행령...