Professor Reshkin has a long-standing expertise in the biology of the NHE1 system and has extensively investigated its role in tumor transformation and malignancy, resulting in more than 40 publications on this topic alone. Last year, he was Guest Author and Editor, together with Salvador Harguindey, on a Special Issue in Seminars in Cancer Biology concerning the role of pH in cancer and neurodegeneration. Recently, his group has provided a structural basis for this role of the NHE1 in tumor cell invasion and the regulation of proteolytic activity localized at invadopodia. To perform this, the Reshkin group has developed a series of innovative techniques to study the dynamics of invadopodia.