Background: Pre-eclampsia remains a leading cause of maternal and perinatal morbidity and mortality worldwide, with a disproportionately high burden in low- and middle-income countries. Nurses are often the first healthcare providers to encounter pregnant women in obstetric emergency settings, making their knowledge of pre-eclampsia management critical for timely intervention and prevention of complications.Objective: To assess nurses’ knowledge regarding the management of pre-eclampsia at Rangpur Community Medical College Hospital, Rangpur, Bangladesh.Methods: A descriptive cross-sectional study was conducted among 50 senior staff nurses working in the Gynaecology, Obstetrics, Labour, and CCU/ICU wards from January to June 2026. A purposive sampling technique was employed, and data were collected us-ing a self-administered structured questionnaire comprising 20 knowledge-related items. Knowledge levels were categorized as high (16–20), moderate (10–15), and low (0–9). Data were analyzed using SPSS version 20, with descriptive statistics and Chi-square tests applied.Results: The majority of respondents were aged 26–30 years (n=9 at age 26), female (80.0%), married (68.0%), and from rural areas (78.0%). Most were Muslim (90.0%), held a B.Sc. in Nursing (60.0%), and worked in the Obstetrics ward (38.0%). Overall, 50.0% demonstrated high knowledge, 46.0% moderate knowledge, and 4.0% low knowl-edge. High knowledge was observed in identifying labetalol as first-line antihypertensive (98.0%), 24-hour urine protein as the most indicative diagnostic test (100%), and ensuring airway patency during seizures (84.0%). However, significant gaps were identified: only 22.0% correctly identified seizure prevention as the goal of magnesium sulfate therapy, and only 16.0% knew calcium gluconate as the antidote for magnesium toxicity. Chi-square analysis revealed a statistically significant association between working department andknowledge level (χ2 = 22.159, df=6, p = .001), but no significant association between academic qualification and knowledge level (χ2 = 3.004, df=2, p = .223).Conclusion: While the majority of nurses demonstrated satisfactory overall knowledge, critical gaps exist regarding magnesium sulfate therapy and toxicity management. Targeted educational interventions and continuous professional development are urgently needed to strengthen nurses’ competence in pre-eclampsia management.