Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone. Subsequent CuAAC click reaction with propargylated derivatives provided an efficient synthetic route to a set of terpenyl-derived conjugates with increased solubility in water. All investigated compounds exhibit high antioxidant activity, which is comparable with that of vitamin C. It was also found that serum albumin and the terpenyl-1,2,3-triazoles hybrids spontaneously undergo reversible binding driven by hydrophobic interactions, suggesting that serum albumin can transport the target triazoles.

The effect of various ions ( ${\mathrm{Na}}^{+},\mathrm{ }{\mathrm{Li}}^{+},\mathrm{ }{\mathrm{Cl}}^{-},\mathrm{ }$and ${\mathrm{ClO}}_4^{-}$) on the thermal stability of BSA in DMSO containing solutions has been studied using electronic absorption and FTIR spectroscopy methods. The mechanism of protein heat induced denaturation based on of UV profiles has been revealed. Quantitative analysis of BSA FTIR spectra amide I deconvoluted band before and after denaturation showed that in DMSO aqueous solution of NaCl, LiCl and LiClO₄ the changes in secondary structure of protein depend on the properties of mixed solvent and the solvated state of ions. BSA undergoes to minimum changes in the presence of ${\mathit{ClO}}_4^{-}$ ions.