Aim: To date, various molecules have been investigated to reduce the effect of renal ischemia/reperfusion (I/R) injury. However, none have yet led to clinical use. The present study aimed to investigate the protective effect of cordycepin (C) on renal I/R injury in an experimental rat model. Materials and methods: Twenty-four mature Sprague Dawley female rat was randomly divided into three groups: Sham, I/R, I/R+C. All animals underwent abdominal exploration. To induce I/R injury, an atraumatic vascular bulldog clamp was applied to the right renal pedicle for 60 minutes (ischemia) and later clamp was removed to allow reperfusion in all rats, except for the sham group. In the I/R + C group, 10 mg/kg C was administered intraperitoneally, immediately after reperfusion. After 4 hours of reperfusion, the experiment was terminated with right nephrectomy. Histological studies and biochemical analyses were performed on the right nephrectomy specimens. EGTI (endothelial, glomerular, tubulointerstitial) histopathology scoring and semi-quantitative analysis of renal cortical necrosis were used for histological analyses and superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), total oxidant status (TOS) for biochemical analyses. Results: Histopathological examination of the tissue damage revealed that all kidneys in the sham group were normal. The I/R group had higher histopathological scores than the I/R + C group. In the biochemical analysis of the tissues, SOD, MDA, TOS values were found to be statistically different in the I/R group compared to the I/R + C group (p: 0.004, 0.004, 0.001 respectively). Conclusions: Intraperitoneal cordycepin injection following ischemia preserve renal tissue against oxidative stress in a rat model of renal I/R injury.

Introduction: To determine whether a combination of the long acting local anesthetic, bupivacaine, and lidocaine is better than lidocaine alone in the long-term pain control, which is a short-acting anesthetic. Materials and Methods: In group 1, periprostatic nerve block was applied to both neurovascular areas with 2% lidocaine (5 ml) in an isotonic solution (5 ml). In group 2, the combination of 2% lidocaine (5 ml) and 5mg/ml bupivacaine (5 ml) was used for the PPNB. Results: In the first 30 minutes the mean VAS scores of groups 1 and 2 were 2.1 ± 0.2 and 1.2 ± 0.1, respectively (p = 0.002). VAS scores of group II determined at 1, 2, 4, 6, and 8 hours after the biopsy were significantly lower since it was (p < 0.05). Conclusion: While periprostatic nerve block for late phase pain control, applying a combination of a long-acting local anesthetic, such as bupivacaine, is effective in terms of pain control and patient comfort.

Objective: To evaluate the outcomes of flouroscopy-free retrograde intrarenal surgery (ffRIRS) and to investigate the factors that may affect stone-free rate. Materials and methods: The charts of patients who underwent ffRIRS between January 2017 and August 2019 were reviewed retrospectively. Patients with missing preoperative imaging and patients with kidney anomalies were excluded from the study. Age, gender, stone size, stone localization, stone density, laterality, operation time, stone-free rate, complications and auxiliary procedures were recorded and analyzed. Results: Study group involved 44 (43.1%) female and 58 (56.8%) male patients. Stone-free rate in a single-session ffRIRS were found to be correlated with stone localization (p = 0.003), stone volume (p = 0.004), and stone density (p = 0.009) but not with age (p = 0.950). Patients with multiple calyceal stones and a stone burden over 520 mm3 were found to be less stone-free. The complication rate in female gender (n = 7) was significantly higher compared to male (n = 1) (p = 0.011). No major complications such as ureteral injury or avulsion were observed. Overall, 13 patients (12.7%) needed auxiliary procedures. The operation time seemed to be affected by stone size and gender (p = 0.005; p = 0.044, respectively). Conclusions: Stone-free rate in ffRIRS were found to be affected by stone density, size, and localization. Patients with multiple caliceal stones and high stone burden (< 520 mm3) have been found to have low stone-free rate, so one can speculate that having fluoroscopy assistance in RIRS might help us to improve surgical success.

We aimed to evaluate the factors predictive of ureteral stenosis after orifice resection and to determine whether ureteral stenting is effective in prevent

Objective: In our retrospectively planned study; treated with ESWL method; we aimed to investigate the factors that predict the success of Extracorporeal Shock Wave Lithotripsy (ESWL) and its reliability in our patients with ureteral stones. Material and Methods: The study includes 489 patients treated for ureteral stones at Atatürk University Urology Clinic between 2008 and 2013. Patients underwent a maximum of three sessions of ESWL. Those who had fractures within two sessions were considered successful. Patients who underwent ESWL due to ureteral stones were retrospectively examined from hospital records. In predicting ESWL success, parameters such as gender, age, opacity, side and complication rates, and the need for additional procedures were evaluated. In patients who were stone-free after ESWL or had residual stones smaller than 4 mm on control imaging, ESWL was considered successful and stone-free was achieved. Sedoanalgesia was applied only to pediatric patients. Results: A total of 486 patients who underwent ESWL for ureteral stones were included in the study. The patients were divided into 3 groups according to age groups. Ages 1-18 were the first group, ages 20-40 were the second group, and people over 40 were the third group. Stone-free status was not statistically significant in terms of age groups and gender parameters. As a complication, stone street developed in 3 patients and hematuria developed in 2 patients. No significance was found between complications and the location of the stones (p=0.531). There was a significance between stone size and stone-free status and the development of complications (p=0.016, p=0.0001, respectively). Conclusion: It is essential to predict treatment success in ESWL and to protect patients from complications, time loss and morbidity that may arise from unnecessary treatment and procedures. In our study with large patient participation, we showed that ESWL is a method that can be safely preferred in ureteral stones with high success and low complication rates. In our study, stone size was found to be an important predictive value in predicting success.