We report the results of the first search for gravitational waves from compact binary coalescence using data from the Laser Interferometer Gravitational-Wave Observatory and Virgo detectors. Five months of data were collected during the Laser Interferometer Gravitational-Wave Observatory’s S5 and Virgo’s VSR1 science runs. The search focused on signals from binary mergers with a total mass between 2 and $35M_{\odot }$. No gravitational waves are identified. The cumulative 90%-confidence upper limits on the rate of compact binary coalescence are calculated for nonspinning binary neutron stars, black hole-neutron star systems, and binary black holes to be $8.7\times {10}^{-3}{\mathrm{yr}}^{-1}{\mathrm{L}}_{10}^{-1}$, $2.2\times {10}^{-3}{\mathrm{yr}}^{-1}{\mathrm{L}}_{10}^{-1}$, and $4.4\times {10}^{-4}{\mathrm{yr}}^{-1}{\mathrm{L}}_{10}^{-1}$, respectively, where ${\mathrm{L}}_{10}$ is ${10}^{10}$ times the blue solar luminosity. These upper limits are compared with astrophysical expectations.

Sortilin has been positively correlated with vascular disorders in humans. No study has yet evaluated the possible direct effect of sortilin on vascular function. We used pharmacological and genetic approaches coupled with study of murine and human samples to unravel the mechanisms recruited by sortilin in the vascular system. Sortilin induced endothelial dysfunction of mesenteric arteries through NADPH oxidase 2 (NOX2) isoform activation, dysfunction that was prevented by knockdown of acid sphingomyelinase (ASMase) or sphingosine kinase 1. In vivo, recombinant sortilin administration induced arterial hypertension in WT mice. In contrast, genetic deletion of sphingosine-1-phosphate receptor 3 (S1P3) and gp91phox/NOX2 resulted in preservation of endothelial function and blood pressure homeostasis after 14 days of systemic sortilin administration. Translating these research findings into the clinical setting, we detected elevated sortilin levels in hypertensive patients with endothelial dysfunction. Furthermore, in a population-based cohort of 270 subjects, we showed increased plasma ASMase activity and increased plasma levels of sortilin, S1P, and soluble NOX2-derived peptide (sNOX2-dp) in hypertensive subjects, and the increase was more pronounced in hypertensive subjects with uncontrolled blood pressure. Our studies reveal what we believe is a previously unrecognized role of sortilin in the impairment of vascular function and in blood pressure homeostasis and suggest the potential of sortilin and its mediators as biomarkers for the prediction of vascular dysfunction and high blood pressure.

The LIGO and the Virgo collaborations have recently announced the first detections of Gravitational Waves. Due to their weak amplitude, Gravitational Waves are expected to produce a very small effect on free-falling masses, which undergo a displacement of the order of 10-18 m for a Km-scale mutual distance. This discovery showed that interferometric detectors are suitable to reveal such a feeble effect, and therefore represent a new tool for astronomy, astrophysics and cosmology in the understanding of the Universe. To better reconstruct the position of the Gravitational Wave source and increase the signal-to-noise ratio of the events by means of multiple coincidence, a network of detectors is necessary. In the USA, the LIGO project has recently concluded its second Observation Run (O2) with a couple of twin 4 kilometer-long arms detectors which are placed in Washington State and Louisiana. Advanced VIRGO (AdV) is a 3 kilometer-long arms second generation interferometer situated in Cascina, near Pisa in Italy. The installation of AdV has been completed in 2016, and the first commissioning phase allowed to get to the target early-stage sensitivity, which was sufficient to join LIGO in the O2 scientific run. In this paper, the challenges of the commissioning of AdV will be presented, together with its current performances and future perspectives. Finally, in the last paragraph the latest discoveries that occurred after the ICNFP 2017 conference will be also described.