Background: Pain management in wilderness and austere care must balance humane, effective analgesia against limited monitoring, environmental exposure, restricted drug inventories, and evacuation delays that may last hours. This review evaluates practical analgesic strategies for prolonged wilderness evacuation and quantitatively synthesizes directly comparable prehospital ketamine-versus-morphine trials. Methods: A focused systematic search of PubMed/MEDLINE-indexed literature and backward citation chaining was conducted through September 5, 2026. Human prehospital, wilderness, remote, austere, and prolonged-field-care studies evaluating acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, ketamine, or regional anesthesia were prioritized. Guidelines and systematic reviews were used to contextualize operational feasibility. A random-effects meta-analysis pooled studies reporting directly comparable changes in 0-10 pain intensity for ketamine versus morphine. Results: Direct evidence specific to prolonged civilian wilderness evacuation was sparse. Across the broader prehospital literature, acetaminophen and NSAIDs provided useful low-complexity analgesia for mild-to-moderate pain and as components of multimodal therapy. Opioids remained effective for severe pain but impose respiratory, hemodynamic, nausea, sedation, and monitoring burdens. Ketamine produced analgesia broadly comparable with morphine in contemporary randomized trials, with faster onset in some studies and a different adverse-effect profile characterized by more emergence phenomena but less opioid-associated nausea, hypotension, or respiratory compromise in some datasets. Two directly comparable trials (n=559) yielded a pooled mean difference in pain-score change of -0.27 points favoring ketamine (95% CI, -0.70 to 0.17; I2=13%), indicating no clinically important difference in analgesic efficacy. Regional techniques, particularly fascia iliaca compartment block for proximal femur injury, showed substantial opioid-sparing potential when performed by trained clinicians. Conclusions: No single agent is optimal for prolonged wilderness evacuation. The most defensible strategy is staged multimodal analgesia matched to pain severity, physiology, evacuation duration, provider skill, and monitoring capacity. Oral acetaminophen and/or an NSAID form a practical foundation when not contraindicated; severe pain may justify titrated ketamine or an opioid, while regional anesthesia can be valuable for selected injuries. The major evidence gap is not short-term analgesic efficacy but safety, redosing, monitoring, and functional outcomes during evacuations lasting many hours.