Multi-agent Pickup and Delivery (MAPD) is a challenging industrial problem where a team of robots is tasked with transporting a set of tasks, each from an initial location and each to a specified target location. Appearing in the context of automated warehouse logistics and automated mail sortation, MAPD requires first deciding which robot is assigned what task (i.e., Task Assignment or TA) followed by a subsequent coordination problem where each robot must be assigned collision-free paths so as to successfully complete its assignment (i.e., Multi-Agent Path Finding or MAPF). Leading methods in this area solve MAPD sequentially: first assigning tasks, then assigning paths. In this work we propose a new coupled method where task assignment choices are informed by actual delivery costs instead of by lower-bound estimates. The main ingredients of our approach are a marginal-cost assignment heuristic and a meta-heuristic improvement strategy based on Large Neighbourhood Search. As a further contribution, we also consider a variant of the MAPD problem where each robot can carry multiple tasks instead of just one. Numerical simulations show that our approach yields efficient and timely solutions and we report significant improvement compared with other recent methods from the literature.

We study prioritized planning for Multi-Agent Path Finding (MAPF). Existing prioritized MAPF algorithms depend on rule-of-thumb heuristics and random assignment to determine a fixed total priority ordering of all agents a priori. We instead explore the space of all possible partial priority orderings as part of a novel systematic and conflict-driven combinatorial search framework. In a variety of empirical comparisons, we demonstrate state-of-the-art solution qualities and success rates, often with similar runtimes to existing algorithms. We also develop new theoretical results that explore the limitations of prioritized planning, in terms of completeness and optimality, for the first time.

Summary: Protein topology diagrams are 2D representations of protein structure that are particularly useful in understanding and analysing complex protein folds. Generating such diagrams presents a major problem in graph drawing, with automatic approaches often resulting in errors or uninterpretable results. Here we apply a breakthrough in diagram layout to protein topology cartoons, providing clear, accurate, interactive and editable diagrams, which are also an interface to a structural search method. Availability: Pro-origami is available via a web server at http://munk.csse.unimelb.edu.au/pro-origami Contact:a.stivala@pgrad.unimelb.edu.au; pjs@csse.unimelb.edu.au