Using the colloidal solution combustion approach, a three-dimensional mesoporous 5%Ni-CeO₂-M catalyst was developed, with Ni incorporated into the pores, and applied in the dry reforming of methane. Comprehensive characterization revealed that the 5%Ni-CeO₂-M catalyst had a large specific surface area and a three-dimensional mesoporous structure. A rich Ni-CeO₂ interface was formed by closely spaced tiny CeO₂ and NiO nanoparticles within the spherical pore wall. With very little carbon deposition over a 100 h period at 700 °C, the catalyst showed excellent activity and stability. The tiny Ni nanoparticles, along with the substantial Ni-CeO₂ interfaces that make up this three-dimensional in-form mesoporous catalyst, are responsible for the outstanding effectiveness of this 5%Ni-CeO₂-M catalyst.