The sustained deployment of human missions and permanent settlements on Mars will depend on highly reliable electrical power systems to support life-support facilities, habitats, scientific instruments, communication networks, in-situ resource utilization, transportation, and other mission-critical operations. The safety and uninterrupted operation of astronauts’ electrical and electronic equipment,including spacesuits, rovers, autonomous robots, sensing devices, and power electronics are equally essential for mission success. This is because, electrostatic discharge (ESD) generated during Martian dust storms may pose significant risks by affecting spacecraft electronics, communication systems, scientific instruments, and solar photovoltaic (PV) power systems through tribo electric charging, dust deposition, and electrical breakdown. Accurate prediction of these coupled phenomena remains challenging because conventional models do not simultaneously account for atmospheric flow, particle electrification, electric-field evolution, and dynamic gas breakdown under Martian environmental conditions. This research presents an integrated computational and experimental framework that combines Computational Fluid Dynamics (CFD), a Physics-Informed Neural Network (PINN), and a novel Dynamic Mars Paschen Model (DMPM) to predict electrostatic discharge and assess its impact on Martian surface sys tems. The CFD model simulates airflow, dust transport, and pressure distribution within a Martian environmental chamber, while the PINN incorporates the governing equations of fluid flow, charge conservation, and electrostatic field evolution to efficiently predict triboelectric charge accumulation and electric-field intensity. The proposed DMPM extends the classical Paschen law by incorporating the effects of airflow velocity, dust concentration, atmospheric temperature, triboelectric charge density, and carbon dioxide frost coverage to estimate the dynamic breakdown voltage under realistic Martian conditions. Experimental validation con ducted in a purpose-built Martian environmental chamber demonstrated excellent agreement between numerical predictions and laboratory measurements, with coefficients of determination exceeding 0.98 and prediction errors generally below 3%. Beyond electrostatic discharge prediction, the developed laboratory provides a sustainable multidisciplinary research platform for investi gating dust-induced degradation of Martian solar PV systems, evaluating electrostatic mitigation technologies, validating planetary instrumentation, and supporting future Mars exploration research. The proposed CFD–PINN–DMPM framework therefore con tributes to improved mission safety, energy-system reliability, and the long-term sustainability of planetary surface operations.