The purpose of this study was to investigate the effect of denture adhesives on oral moisture in a 10-center parallel randomized clinical trial. Two hundred edentulous subjects wearing complete dentures were allocated into three groups: cream-type adhesive, powder-type adhesive and control groups. The adhesives (and saline solution in the control group) were applied to the mucosal surface of the dentures for 4 days, and baseline data and data after the intervention for eight meals over 4 days were obtained. For the main outcome, oral moisture was measured with a moisture checking device. Secondary outcomes were denture satisfaction, masticatory performance, denture retention, and occlusal force. In addition to between-group and within-group comparisons of oral moisture, investigations for secondary outcomes were undertaken in subgroups classified according to the degree of oral moisture at baseline (normal subgroup and dry mouth subgroup). Intention-to-treat analysis was also performed. Between-group and within-group comparisons of oral moisture showed no significant differences. The cream-type and powder-type denture adhesives were significantly effective in the dry mouth group for denture satisfaction ratings of ability to masticate, stability, retention, and comfort of mandibular dentures (p<0.05). The masticatory performance and retentive force of the dry mouth denture adhesive using groups were significantly improved after intervention (p<0.05). The oral moisture of complete denture wearers was not influenced by the use of denture adhesives. Our findings showed that denture adhesives improved subjective denture satisfaction, masticatory performance, and retention for complete denture patients with oral dryness.

Purpose: The purpose of this study was to investigate whether edentulous patients with a permanent acrylic resilient liner denture (RLD) in mandibles exhibit significant improvements in their satisfaction ratings at the first appointment following the delivery of RLD dentures when compared to those with conventional heat-activated acrylic resin dentures (ARD) in mandibles. Methods: Seventy-four subjects were randomly allocated into RLD and ARD groups by a random permuted block within the strata method after written informed consent. A parallel-randomized controlled clinical trial at two centers was conducted from April 2004 to July 2006. The outcomes were satisfaction ratings with a 100 mm visual analog scale (VAS) involving general satisfaction as well as satisfaction related to chewing, speaking, cleaning, stability, retention, comfort, and esthetics. The pain rating was also measured by the VAS. The outcomes were analyzed by Student t-test and Pearson's correlation coefficient. Results: A significant difference between the RLD and ARD group in the maxillary denture was only obtained in the satisfaction rating of speaking. A significant difference between the RLD and ARD groups for the mandibular dentures was obtained in every satisfaction rating. The pain rating of the RLD group was significantly lower than that of the ARD group. The satisfaction ratings of mandibular denture functions significantly correlated with ratings of comfort and pain. Conclusion: Despite the limitation of a short-term observation, the mandibular satisfaction ratings were dramatically higher in RLD wearers than in ARD wearers.