Ionela Andreea Neacsu

Dr. Ionela Andreea Neacsu

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
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Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 February 2022 in Polymers
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Journal Article
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DRDenisa-Maria Radulescu
Denisa-Maria Radulescu
Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
Alexandru Mihai GrumezescuAlexandru Mihai Grumezescu
Alexandru Mihai Grumezescu
EAEcaterina Andronescu
Ecaterina Andronescu
In recent years, biomaterials development and characterization for new applications in regenerative medicine or controlled release represent one of the biggest challenges. Tissue engineering is one of the most intensively studied domain where hydrogels are considered optimum applications in the biomedical field. The delicate nature of hydrogels and their low mechanical strength limit their exploitation in tissue engineering. Hence, developing new, stronger, and more stable hydrogels with increased biocompatibility, is essential. However, both natural and synthetic polymers possess many limitations. Hydrogels based on natural polymers offer particularly high biocompatibility and biodegradability, low immunogenicity, excellent cytocompatibility, variable, and controllable solubility. At the same time, they have poor mechanical properties, high production costs, and low reproducibility. Synthetic polymers come to their aid through superior mechanical strength, high reproducibility, reduced costs, and the ability to regulate their composition to improve processes such as hydrolysis or biodegradation over variable periods. The development of hydrogels based on mixtures of synthetic and natural polymers can lead to the optimization of their properties to obtain ideal scaffolds. Also, incorporating different nanoparticles can improve the hydrogel’s stability and obtain several biological effects. In this regard, essential oils and drug molecules facilitate the desired biological effect or even produce a synergistic effect. This study’s main purpose is to establish the main properties needed to develop sustainable polymeric scaffolds. These scaffolds can be applied in tissue engineering to improve the tissue regeneration process without producing other side effects to the environment.

10 February 2019 in Nanomaterials
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Journal Article
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Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
SEStoica (Oprea) Alexandra Elena
Stoica (Oprea) Alexandra Elena
Bogdan Stefan VasileBogdan Stefan Vasile
Bogdan Stefan Vasile
EAEcaterina Andronescu
Ecaterina Andronescu
One new, promising approach in the medical field is represented by hydroxyapatite doped with luminescent materials for biomedical luminescence imaging. The use of hydroxyapatite-based luminescent materials is an interesting area of research because of the attractive characteristics of such materials, which include biodegradability, bioactivity, biocompatibility, osteoconductivity, non-toxicity, and their non-inflammatory nature, as well their accessibility for surface adaptation. It is well known that hydroxyapatite, the predominant inorganic component of bones, serves a substantial role in tissue engineering, drug and gene delivery, and many other biomedical areas. Hydroxyapatite, to the detriment of other host matrices, has attracted substantial attention for its ability to bind to luminescent materials with high efficiency. Its capacity to integrate a large assortment of substitutions for Ca2+, PO43−, and/or OH− ions is attributed to the versatility of its apatite structure. This paper summarizes the most recently developed fluorescent materials based on hydroxyapatite, which use rare earth elements (REEs) as dopants, such as terbium (Tb3+), erbium (Er3+), europium (Eu3+), lanthanum (La3+), or dysprosium (Dy3+), that have been developed in the biomedical field.

20 February 2020 in Nanomaterials
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Bogdan Stefan VasileBogdan Stefan Vasile
Bogdan Stefan Vasile
ABAda Birca
Ada Birca
Vasile-Adrian SurduVasile-Adrian Surdu
Vasile-Adrian Surdu
Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
Adrian Ionut NicoaraAdrian Ionut Nicoara
Adrian Ionut Nicoara
This paper is focused on the basic properties of ceramic composite materials used as thermal barrier coatings in the aerospace industry like SiC, ZrC, ZrB2 etc., and summarizes some principal properties for thermal barrier coatings. Although the aerospace industry is mainly based on metallic materials, a more attractive approach is represented by ceramic materials that are often more resistant to corrosion, oxidation and wear having at the same time suitable thermal properties. It is known that the space environment presents extreme conditions that challenge aerospace scientists, but simultaneously, presents opportunities to produce materials that behave almost ideally in this environment. Used even today, metal-matrix composites (MMCs) have been developed since the beginning of the space era due to their high specific stiffness and low thermal expansion coefficient. These types of composites possess properties such as high-temperature resistance and high strength, and those potential benefits led to the use of MMCs for supreme space system requirements in the late 1980s. Electron beam physical vapor deposition (EB-PVD) is the technology that helps to obtain the composite materials that ultimately have optimal properties for the space environment, and ceramics that broadly meet the requirements for the space industry can be silicon carbide that has been developed as a standard material very quickly, possessing many advantages. One of the most promising ceramics for ultrahigh temperature applications could be zirconium carbide (ZrC) because of its remarkable properties and the competence to form unwilling oxide scales at high temperatures, but at the same time it is known that no material can have all the ideal properties. Another promising material in coating for components used for ultra-high temperature applications as thermal protection systems is zirconium diboride (ZrB2), due to its high melting point, high thermal conductivities, and relatively low density. Some composite ceramic materials like carbon–carbon fiber reinforced SiC, SiC-SiC, ZrC-SiC, ZrB2-SiC, etc., possessing low thermal conductivities have been used as thermal barrier coating (TBC) materials to increase turbine inlet temperatures since the 1960s. With increasing engine efficiency, they can reduce metal surface temperatures and prolong the lifetime of the hot sections of aero-engines and land-based turbines.

1 January 2016
Verified
Book Chapter
Closed access
Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
Adrian Ionut NicoaraAdrian Ionut Nicoara
Adrian Ionut Nicoara
OVOtilia Ruxandra Vasile
Otilia Ruxandra Vasile
Bogdan Stefan VasileBogdan Stefan Vasile
Bogdan Stefan Vasile

24 February 2022 in Polymers
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Journal Article
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DRDiana-Elena Radulescu
Diana-Elena Radulescu
Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
Alexandru Mihai GrumezescuAlexandru Mihai Grumezescu
Alexandru Mihai Grumezescu
EAEcaterina Andronescu
Ecaterina Andronescu
In recent years, the number of people needing bone replacements for the treatment of defects caused by chronic diseases or accidents has continuously increased. To solve these problems, tissue engineering has gained significant attention in the biomedical field, by focusing on the development of suitable materials that improve osseointegration and biologic activity. In this direction, the development of an ideal material that provides good osseointegration, increased antimicrobial activity and preserves good mechanical properties has been the main challenge. Currently, bone tissue engineering focuses on the development of materials with tailorable properties, by combining polymers and ceramics to meet the necessary complex requirements. This study presents the main polymers applied in tissue engineering, considering their advantages and drawbacks. Considering the potential disadvantages of polymers, improving the applicability of the material and the combination with a ceramic material is the optimum pathway to increase the mechanical stability and mineralization process. Thus, ceramic materials obtained from natural sources (e.g., hydroxyapatite) are preferred to improve bioactivity, due to their similarity to the native hydroxyapatite found in the composition of human bone.

30 March 2022 in Pharmaceutics
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CDCorina Dumitru
Corina Dumitru
Ionela Andreea NeacsuIonela Andreea Neacsu
Ionela Andreea Neacsu
Alexandru Mihai GrumezescuAlexandru Mihai Grumezescu
Alexandru Mihai Grumezescu
EAEcaterina Andronescu
Ecaterina Andronescu
Skin tissue regeneration is one of the population’s most common problems, and the complications that may appear in the healing process can have detrimental consequences. An alternative to conventional treatments could be represented by sustainable materials based on natural products, such as honey and its derivates (propolis, royal jelly, bee pollen, beeswax, and bee venom). They exhibit significant inhibitory activities against bacteria and have great potential in dermal tissue regeneration. Research in the pharmaceutical field demonstrates that conventional medication combined with bee products can deliver better results. The advantages include minimizing side effects and maintaining the same effectiveness by using low concentrations of antibiotic, anti-inflammatory, or chemotherapy drugs. Several studies suggested that bee products can replace the antimicrobial activity and efficiency of antibiotics, but further investigation is needed to establish a topical mixture’s potential, including honey, royal jelly, and propolis. Bee products seem to complete each other’s deficiencies, and their mixture may have a better impact on the wound healing process. The topic addressed in this paper highlights the usefulness of honey, propolis, royal jelly, bee pollen, beeswax, and bee venom in the re-epithelization process and against most common bacterial infections.