The Guerrero terrane comprises Middle Jurassic–Early Cretaceous arc successions that were accreted to the North American craton in the late Early Cretaceous, producing closure of the Arperos oceanic basin and the formation of an approximately 100 km-wide fold–thrust belt. Such a suture is key to investigating the structural evolution related to Guerrero terrane accretion and, in general, to arc–continent collisional zones. The Sierra de Guanajuato is an exposure of the Guerrero terrane suture belt and consists of a complex tectonic pile that formed through at least three major shortening phases: D1SG, D2SG, and D3SG (SG, Sierra de Guanajuato). During the D1SG and D2SG phases, the Upper Jurassic–Lower Cretaceous successions of the Arperos Basin piled up, forming a doubly vergent imbricate fan of thrust sheets that accommodated substantial NE–SW shortening. Mylonite microtextures, as well as syntectonic minerals, indicate that the D1SG and D2SG deformation events took place under low greenschist-facies metamorphic conditions. We relate these deformation phases to the progressive NE migration of the Guerrero terrane, which triggered the collapse and closure of the Arperos Basin. During D3SG, the El Paxtle arc assemblage of the Guerrero terrane was tectonically emplaced onto the previously deformed successions of the Arperos Basin. However, D3SG structures indicate that during this deformational stage, the main shortening direction was oriented NW–SE and that contraction was accommodated mostly by SE-vergent ductile thrusts formed under low greenschist-facies metamorphic conditions. We suggest that the top-to-the-SE emplacement of the El Paxtle assemblage may be a result of the tectonic escape of the arc produced by the continuous NE impingement of the Guerrero terrane during its collisional addition to the Mexican mainland.