Abstract: Background: Propolis is a resinous complex produced by Apis mellifera L. bees whose variety of pharmacological properties is resulting from the complexity of its composition. In dentistry, propolis is used on the prevention of oral diseases such as dental caries and gingivitis. Prospective studies in intellectual property banks are important to increase market competitiveness and thus generate new products in the various research areas. In this way, investments in patents play an important role in the technological and economic development of a country. Objective: To evaluate patents with dental products containing propolis, on intellectual property banks. Method: The research was conducted in 10 banks of intellectual property, including since the first deposits up to 2016. Relevant information that describes the invention in the patent document were collected, processed and described. Results: The search performed in 62 patents using propolis in the dental topic. World Intellectual Property Organization (WIPO) has the largest number of filing patents (83.60%) and the National Institute of Industrial Property (INPI) in third place with 4 patents (6.55%). Built-in dental cream with propolis was the most patented product. The first patent date of 1998, followed by an increase in the number of deposits in the last 20 years. Most of the patents are A61K code (51) for medical, dental or hygienic purposes. Conclusion: This study has shown that propolis is a promising bioactive component in dental products, especially for use in Cariology and Periodontology. Although there has been significant progress in applications of propolis, the field of dental products is still a growing area and it is important to encourage innovation and development of new products incorporating propolis based on knowledge of its composition and therapeutic properties.

Dental caries is a sugar-dependent condition common in childhood, which causes microbiological imbalance in dental biofilm. The present study evaluated the antimicrobial efficacy of a 2.5% Brazilian Red Propolis (BRP) dental varnish to prevent caries in children. Seventy-five children with high caries risk, aged between 36 and 71 months and with no caries, were assigned to three groups to receive varnish treatment containing 2.5% BRP, 1% chlorhexidine, or 5% fluoride. The varnish was applied to the occlusal surfaces of the deciduous second molars on the first day of treatment (D1), after 90 days (D90), and 180 days of the start of treatment (D180). Saliva was collected to assess S. mutans before each varnish application and 180 days at the end of treatment (D360). Values were expressed in log10 (CFU/mL). Statistics were performed by applying repeated measures of variance analysis, Tukey's multiple comparisons test, and paired t-test. In the first dilution (1 : 10), there was microbial load reduction at the following periods: BRP in D0-D90 ( ) and D0-D180 ( ); fluoride in D0-D90 ( ); and chlorhexidine in D0-D180 ( ). In the second dilution (1 : 100), there was microbial load reduction in the groups at the following periods: BRP in D0-D90 ( ) and D0-D180 ( ); fluoride in D0-D180 ( ), and chlorhexidine in D0-180 ( ) and D0-360 ( ). The 2.5% BRP dental varnish was effective in decreasing S. mutans colonies in saliva when used within 90 days.

Background. The objective of this study was to evaluate the clinical and microbiological efficacies of (C. langsdorffii) dental varnish in children at high risk of dental caries.. Methods. This is a longitudinal, randomized, controlled clinical trial. Ninety high-risk caries-free children (ICDAS II = 0) were recruited and randomly divided into three groups: C. langsdorffii, chlorhexidine, or fluoride. The varnishes were applied on the second deciduous molars for three times: baseline (D0), after 90 days (D90), and after 180 days (D180). Saliva was collected on D0, D90, D180, and D360 to evaluate S. mutans reduction. Statistics were carried out by ANOVA, Tukey’s test, and the paired t-test. Results. Copaiba varnish demonstrated significant S. mutans reduction: D360 versus D0 , D180 versus D0 , D360 versus D90 , D180 versus D90 , and D360 versus D180 . Chlorhexidine varnish significantly reduced S. mutans at D180 versus D0 . Fluoride reduced at D180 versus D0 . Conclusions. Three annual applications of this varnish showed substantial antimicrobial activity against S. mutans and caries prevention for up to 12 months.

Introduction. Fluoride plays an important role in the control of dental caries, and currently new dentifrices are being associated with natural products. Objective. This study aimed to evaluate the availability of fluoride in saliva samples after using a dentifrice incorporated with Brazilian red propolis (BRP, INPI Patent no. BR1020170110974) and to compare it to a conventional fluoridated dentifrice in healthy participants. Methods. This study was conducted implementing a double-blind, randomized, controlled, and crossover design. Saliva samples of participants were collected at the following time points: 0 at baseline and 5, 15, 30, 45, and 60 minutes after brushing with each dentifrice. Salivary fluoride concentrations showed no statistically significant difference when comparing the two treatments ( ). All available fluoride concentrations in saliva decreased after one hour, with no significant difference between BRP and conventional fluoridated dentifrice treatment samples ( ). Results. The results showed that there was no difference between the analyzed fluoride concentrations 1 hour after brushing with the different dentifrices. Conclusions. The results of this study suggest that the propolis incorporated in the dentifrice did not interfere with the kinetics and bioavailability of the fluoride ion in saliva samples, enabling its integration with the pharmaceutical formula and thereby promoting its anti-inflammatory and antimicrobial benefits without compromising the anticaries activity of the formulation.

Purpose. This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. Methods. A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. Results. Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35) and 6 (30) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias. Conclusion. The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.

A Farmácia Universitária é um estabelecimento de saúde que desenvolve atividades de ensino, pesquisa e extensão nas áreas magistral e de dispensação de especialidades farmacêuticas, proporcionando aos acadêmicos do curso de farmácia a oportunidade de aliarem os conhecimentos teóricos adquiridos à prática diária das atividades do farmacêutico no exercício da profissão. O artigo tem como objetivo esclarecer os benefícios para a comunidade dos serviços disponibilizados pela farmácia universitária, juntamente com a atuação do Farmacêutico. Trata-se de uma revisão de literatura, na qual utilizou-se para realização da pesquisa as seguintes bases de dados: Pubmed, Bireme e Scielo, sendo selecionados após leitura dos resumos trabalhos completos de 2001 a 2017, perfazendo o total de 31 artigos. Nesse sentido, o farmacêutico assiste e orienta o paciente quanto a sua terapia medicamentosa, o mesmo atua na farmácia universitária que é uma farmácia comunitária que pertence a Instituição de Ensino, comportando atividades de consulta farmacêutica, seguimento farmacoterapêutico, dispensação de medicamentos, análise de água e manipulação de fitoterápicos. Os serviços disponibilizados devem atender as carências dos pacientes, orientando quanto a terapia farmacológica e não farmacológica dos mesmos. Desse modo, a farmácia universitária é um importante degrau para a formação acadêmica dos futuros profissionais, aliando ensino a prática, funcionando como um instrumento para a aproximação do profissional com a comunidade, refletindo no Uso Racional de Medicamentos, alcance de metas farmacoterapêuticas e na inclusão do mesmo junto a equipes multiprofissionais aliando conhecimentos e buscando a melhor efetivação dos serviços de saúde.