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Rosilene Elias
Post-Graduation, Universidade Nove de Julho (UNINOVE), São Paulo 01525-000, Brazil

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Journal article
Published: 19 July 2021 in Toxins
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Several factors contribute to renal-function decline in CKD patients, and the role of phosphate content in the diet is still a matter of debate. This study aims to analyze the mechanism by which phosphate, independent of protein, is associated with the progression of CKD. Adult Munich-Wistar rats were submitted to 5/6 nephrectomy (Nx), fed with a low-protein diet, and divided into two groups. Only phosphate content (low phosphate, LoP, 0.2%; high phosphate, HiP, 0.95%) differentiated diets. After sixty days, biochemical parameters and kidney histology were analyzed. The HiP group presented worse renal function, with higher levels of PTH, FGF-23, and fractional excretion of phosphate. In the histological analysis of the kidney tissue, they also showed a higher percentage of interstitial fibrosis, expression of α-actin, PCNA, and renal infiltration by macrophages. The LoP group presented higher expression of beclin-1 in renal tubule cells, a marker of autophagic flux, when compared to the HiP group. Our findings highlight the action of phosphate in the induction of kidney interstitial inflammation and fibrosis, contributing to the progression of renal disease. A possible effect of phosphate on the dysregulation of the renal cell autophagy mechanism needs further investigation with clinical studies.

ACS Style

Irene Duayer; Eduardo Duque; Clarice Fujihara; Ivone de Oliveira; Luciene dos Reis; Flavia Machado; Fabiana Graciolli; Vanda Jorgetti; Roberto Zatz; Rosilene Elias; Rosa Moysés. The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease. Toxins 2021, 13, 503 .

AMA Style

Irene Duayer, Eduardo Duque, Clarice Fujihara, Ivone de Oliveira, Luciene dos Reis, Flavia Machado, Fabiana Graciolli, Vanda Jorgetti, Roberto Zatz, Rosilene Elias, Rosa Moysés. The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease. Toxins. 2021; 13 (7):503.

Chicago/Turabian Style

Irene Duayer; Eduardo Duque; Clarice Fujihara; Ivone de Oliveira; Luciene dos Reis; Flavia Machado; Fabiana Graciolli; Vanda Jorgetti; Roberto Zatz; Rosilene Elias; Rosa Moysés. 2021. "The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease." Toxins 13, no. 7: 503.

Journal article
Published: 01 June 2021 in Brazilian Journal of Nephrology
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Introduction: Body composition is critical for the evaluation of patients with Chronic Kidney Disease (CKD) and can be obtained from either multifrequency bioelectrical impedance analysis (BIA) or dual-energy absorptiometry (DXA). Although the discrepancy between the results obtained from both methods has already been described, reasons are unknown, and might be related to secondary hyperparathyroidism, which is associated with bone loss. Methods: We have evaluated 49 patients (25 males and 24 females): 20 with CKD not on dialysis and 29 on maintenance hemodialysis [18 with severe hyperparathyroidism (HD-SHPT) and 11 submitted to parathyroidectomy (HD-PTX)]. All patients underwent DXA and BIA. Results: The median age and body mass index (BMI) were 49 years and 25.6 kg/m2, respectively. Patients exhibited low bone mineral content (BMC) measured by DXA, particularly those from the HD-SHPT group. The largest BMC measurement disagreement between DXA and BIA was found in the HD-SHPT group (p=0.004). Factors independently associated with this discrepancy in BMC measurement were serum phosphate (p=0.003) and patient group (p=0.027), even after adjustments for age, BMI, and gender (adjusted r2=0.186). PTX attenuated this difference. Discussion: BIA should be interpreted with caution in patients with SHPT due to a loss of accuracy, which can compromise the interpretation of body composition.

ACS Style

Shirley Ferraz Crispilho; Eduardo Jorge Duque; Kalyanna Soares Bezerra; Rosa Maria R. Pereira; Vanda Jorgetti; Rosilene M. Elias; Rosa M. A. Moysés. The disparity of measuring bone mineral content using bioimpedance and dual-energy absorptiometry in the context of hyperparathyroidism. Brazilian Journal of Nephrology 2021, 43, 269 -273.

AMA Style

Shirley Ferraz Crispilho, Eduardo Jorge Duque, Kalyanna Soares Bezerra, Rosa Maria R. Pereira, Vanda Jorgetti, Rosilene M. Elias, Rosa M. A. Moysés. The disparity of measuring bone mineral content using bioimpedance and dual-energy absorptiometry in the context of hyperparathyroidism. Brazilian Journal of Nephrology. 2021; 43 (2):269-273.

Chicago/Turabian Style

Shirley Ferraz Crispilho; Eduardo Jorge Duque; Kalyanna Soares Bezerra; Rosa Maria R. Pereira; Vanda Jorgetti; Rosilene M. Elias; Rosa M. A. Moysés. 2021. "The disparity of measuring bone mineral content using bioimpedance and dual-energy absorptiometry in the context of hyperparathyroidism." Brazilian Journal of Nephrology 43, no. 2: 269-273.

Letter to the editor
Published: 24 April 2021 in Journal of Stroke and Cerebrovascular Diseases
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ACS Style

Luci Carla D.B. Carvalho; Mariana P. Velozo; Venceslau A Coelho; Melani R. Custodio; Maria Aparecida Dalboni; Rosa M.A. Moysés; Rosilene M. Elias. Low Levels of Klotho are Associated with Intracranial Vascular Calcification in Patients with CKD. Journal of Stroke and Cerebrovascular Diseases 2021, 105745 .

AMA Style

Luci Carla D.B. Carvalho, Mariana P. Velozo, Venceslau A Coelho, Melani R. Custodio, Maria Aparecida Dalboni, Rosa M.A. Moysés, Rosilene M. Elias. Low Levels of Klotho are Associated with Intracranial Vascular Calcification in Patients with CKD. Journal of Stroke and Cerebrovascular Diseases. 2021; ():105745.

Chicago/Turabian Style

Luci Carla D.B. Carvalho; Mariana P. Velozo; Venceslau A Coelho; Melani R. Custodio; Maria Aparecida Dalboni; Rosa M.A. Moysés; Rosilene M. Elias. 2021. "Low Levels of Klotho are Associated with Intracranial Vascular Calcification in Patients with CKD." Journal of Stroke and Cerebrovascular Diseases , no. : 105745.

Articles
Published: 26 February 2021 in Brazilian Journal of Nephrology
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Thrombocytopenia is frequently observed in hemodialysis patients, and its correct investigation and control remain a challenge. It is estimated that during the hemodialysis session there is a drop of up to 15% in the platelet count, with recovery after the end of treatment. This reduction in platelets is due to platelet adhesion and complement activation, regardless of the membrane material. Several studies with platelet surface markers demonstrate increased platelet activation and aggregation secondary to exposure to cardiopulmonary bypass. This case report describes a patient on hemodialysis who developed severe thrombocytopenia during hospitalization. Investigation and exclusion of the most common causes were carried out: heparin-related thrombocytopenia, adverse drug reaction, hypersplenism, and hematological diseases. Afterwards, the possibility of hemodialysis-related thrombocytopenia was raised, since the fall was accentuated during the sessions with partial recovery after the dialyzer change. Attention to the sterilization method and dialyzer reuse must be considered for correction. In the current case, reusing the dialyzer minimized the drop in platelet counts associated with hemodialysis.

ACS Style

Irene Faria Duayer; Maria Júlia Correia Lima Nepomuceno Araújo; Camila Hitomi Nihei; Maria Alice Fernandes Barcelos; Osni Braga; Zita Maria Leme Britto; Rosilene Mota Elias. Dialysis-related thrombocytopenia: a case report. Brazilian Journal of Nephrology 2021, 1 .

AMA Style

Irene Faria Duayer, Maria Júlia Correia Lima Nepomuceno Araújo, Camila Hitomi Nihei, Maria Alice Fernandes Barcelos, Osni Braga, Zita Maria Leme Britto, Rosilene Mota Elias. Dialysis-related thrombocytopenia: a case report. Brazilian Journal of Nephrology. 2021; (AHEAD):1.

Chicago/Turabian Style

Irene Faria Duayer; Maria Júlia Correia Lima Nepomuceno Araújo; Camila Hitomi Nihei; Maria Alice Fernandes Barcelos; Osni Braga; Zita Maria Leme Britto; Rosilene Mota Elias. 2021. "Dialysis-related thrombocytopenia: a case report." Brazilian Journal of Nephrology , no. AHEAD: 1.

Journal article
Published: 15 December 2020 in Sleep Medicine
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To explore the status of concentration of klotho and fibroblast growth factor 23 (FGF23) in cerebrospinal fluid (CSF) of patients with narcolepsy. 59 patients with narcolepsy and 17 control individuals were enrolled. We used radioimmunoassay, human klotho enzyme-linked immunosorbent assay (ELISA), human intact FGF23 ELISA and spectrophotometry to measure hypocretin-1, klotho, FGF-23 and phosphorus, respectively. T-Student Test was used to compare klotho and phosphate concentrations, Mann–Whitney U Test were used to compare FGF-23 levels between groups. ANOVA Test was used to compare klotho and phosphate CSF concentrations among narcolepsy patients with CSF hypocretin-1 110 pg/ml (HCRT+) versus control subjects. Klotho and phosphorus CSF levels were lower in narcoleptic patients than in control (908.18 ± 405.51 versus 1265.78 ± 523.26 pg/ml; p = 0.004 and 1.34 ± 0.25 versus 1.58 ± 0.23 mg/dl; p = 0.001, respectively). We found higher FGF-23 levels in narcoleptic patients (5.51 versus 4.00 pg/mL; p = 0.001). Klotho and phosphorus CSF levels were lower in both HCRT- and HCRT+ than controls. Moreover, there were higher FGF-23 levels in both HCRT-/HCRT+ groups versus controls. However, we did not find differences comparing HCRT- and HCRT+ groups, analyzing CSF klotho, FGF-23 or phosphorus levels. Patients with narcolepsy have decreased CSF concentration of klotho and increased CSF levels of FGF-23. These findings may play a role in understanding the pathogenesis of narcolepsy.

ACS Style

Giuliano Da Paz Oliveira; Rosilene Motta Elias; Gustavo Bruniera Peres Fernandes; Rosa Moyses; Sergio Tufik; Denis Bernardi Bichuetti; Fernando Morgadinho Santos Coelho. Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy. Sleep Medicine 2020, 78, 57 -62.

AMA Style

Giuliano Da Paz Oliveira, Rosilene Motta Elias, Gustavo Bruniera Peres Fernandes, Rosa Moyses, Sergio Tufik, Denis Bernardi Bichuetti, Fernando Morgadinho Santos Coelho. Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy. Sleep Medicine. 2020; 78 ():57-62.

Chicago/Turabian Style

Giuliano Da Paz Oliveira; Rosilene Motta Elias; Gustavo Bruniera Peres Fernandes; Rosa Moyses; Sergio Tufik; Denis Bernardi Bichuetti; Fernando Morgadinho Santos Coelho. 2020. "Decreased concentration of klotho and increased concentration of FGF23 in the cerebrospinal fluid of patients with narcolepsy." Sleep Medicine 78, no. : 57-62.

Case report
Published: 10 December 2020 in Blood Purification
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Mineral and bone metabolism disorders are relatively common among patients with end-stage renal disease on maintenance hemodialysis. Corneal and conjunctival calcification is the main extravascular site for calcification. Recently, this form of calcification has been linked to vascular calcification. Secondary hyperparathyroidism can lead to high levels of calcium and phosphorus and increase the risk of calcification. Here, we report a case of a 38-year-old female with severe hyperparathyroidism who underwent eye examination before and after parathyroidectomy. Anterior segment optical coherence tomography showed an improvement in the number and size of ocular calcifications 6 months after surgery. This case calls attention to the importance of eye examination in patients on dialysis and brings the possibility of recovery of calcification in a short-term follow-up.

ACS Style

Maria Beatriz C.N. Pessoa; Ruth Miyuki Santo; Aline A. De Deus; Eduardo Jorge Duque; Carlos Eduardo Rochitte; Rosa M.A. Moyses; Rosilene M. Elias. Corneal and Conjunctival Calcification in a Dialysis Patient Reversed by Parathyroidectomy. Blood Purification 2020, 1 -3.

AMA Style

Maria Beatriz C.N. Pessoa, Ruth Miyuki Santo, Aline A. De Deus, Eduardo Jorge Duque, Carlos Eduardo Rochitte, Rosa M.A. Moyses, Rosilene M. Elias. Corneal and Conjunctival Calcification in a Dialysis Patient Reversed by Parathyroidectomy. Blood Purification. 2020; ():1-3.

Chicago/Turabian Style

Maria Beatriz C.N. Pessoa; Ruth Miyuki Santo; Aline A. De Deus; Eduardo Jorge Duque; Carlos Eduardo Rochitte; Rosa M.A. Moyses; Rosilene M. Elias. 2020. "Corneal and Conjunctival Calcification in a Dialysis Patient Reversed by Parathyroidectomy." Blood Purification , no. : 1-3.

Study protocol
Published: 07 November 2020 in BMC Nephrology
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Background Renal replacement therapy (RRT) is usually indicated for patients with chronic kidney disease (CKD) with glomerular filtration rate below 10 ml/ml/min/1.73m2. However, the need for RRT and timing of dialysis initiation are debatable for patients aged 70 years or older. We here describe the study design and methodology of the Aging Nephropathy Study (AGNES) protocol that aims at evaluating to what extent geriatric-related conditions such as frailty, cognitive dysfunction, and presence of comorbidities have an impact on survival and RRT initiation in this group of patients. In this manuscript we provide detailed information about the AGNES study design and methodology. Methods AGNES is a prospective observational cohort that aim to investigate clinical, biochemical and demographic factors associated with RRT initiation and mortality of patients with CKD stage 4 or 5 who are aged 70 years and older. We plan to include 200 patients over 5 years. Clinically stable outpatients on conservative management for at least 6 months will be recruited from the Nephrogeriatric Clinic at the Hospital das Clinicas da Universidade de Sao Paulo, Brazil. Eligible patients are submitted to a full clinical examination, geriatric assessment, and blood test at baseline. Following the baseline visit the patients are being monitored during an observational follow up period of at least 12 months during which patients will be contacted in the clinic at their regular follow up or by phone until either RRT initiation or death occurs. This cohort includes evaluation of cognition by the education-adjusted 10-point Cognitive Screener (10-CS), frailty by Fried index score, a complete nutritional assessment (by body composition assessment, global subjective assessment and dietary intake), comorbidities by Charlson comorbidity index and biochemical markers including FGF-23 and Klotho. Discussion The AGNES cohort, a real-world study of current clinical practice in elderly patients with advanced CKD prior to dialysis initiation, will shed light into progression of CKD and its complications, indications of RRT and factors determining survival. This investigation will elucidate to what extent geriatric conditions, nutritional status and clinical factors are associated with survival, quality of life and RRT initiation in elderly CKD patients not yet on dialysis. Trial registration Registered on ClinicalTrials.gov on 18 October 2019 (NCT04132492).

ACS Style

Venceslau A. Coelho; Giovani Gn. Santos; Carla M. Avesani; Cicero Italo L. Bezerra; Luana Cristina A. Silva; Julia C. Lauar; Bengt Lindholm; Peter Stenvinkel; Wilson Jacob-Filho; Irene L. Noronha; Roberto Zatz; Rosa M. A. Moysés; Rosilene M. Elias. Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease. BMC Nephrology 2020, 21, 1 -8.

AMA Style

Venceslau A. Coelho, Giovani Gn. Santos, Carla M. Avesani, Cicero Italo L. Bezerra, Luana Cristina A. Silva, Julia C. Lauar, Bengt Lindholm, Peter Stenvinkel, Wilson Jacob-Filho, Irene L. Noronha, Roberto Zatz, Rosa M. A. Moysés, Rosilene M. Elias. Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease. BMC Nephrology. 2020; 21 (1):1-8.

Chicago/Turabian Style

Venceslau A. Coelho; Giovani Gn. Santos; Carla M. Avesani; Cicero Italo L. Bezerra; Luana Cristina A. Silva; Julia C. Lauar; Bengt Lindholm; Peter Stenvinkel; Wilson Jacob-Filho; Irene L. Noronha; Roberto Zatz; Rosa M. A. Moysés; Rosilene M. Elias. 2020. "Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease." BMC Nephrology 21, no. 1: 1-8.

Articles
Published: 26 October 2020 in Brazilian Journal of Nephrology
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Patients on hemodialysis are exposed to calcium via the dialysate at least three times a week. Changes in serum calcium vary according to calcium mass transfer during dialysis, which is dependent on the gradient between serum and dialysate calcium concentration (d[Ca]) and the skeleton turnover status that alters the ability of bone to incorporate calcium. Although underappreciated, the d[Ca] can potentially cause positive calcium balance that leads to systemic organ damage, including associations with mortality, myocardial dysfunction, hemodynamic tolerability, vascular calcification, and arrhythmias. The pathophysiology of these adverse effects includes serum calcium changes, parathyroid hormone suppression, and vascular calcification through indirect and direct effects. Some organs are more susceptible to alterations in calcium homeostasis. In this review, we discuss the existing data and potential mechanisms linking the d[Ca] to calcium balance with consequent dysfunction of the skeleton, myocardium, and arteries.

ACS Style

Rosilene M. Elias; Sharon Moe; Rosa M. A Moysés. Skeletal and cardiovascular consequences of a positive calcium balance during hemodialysis. Brazilian Journal of Nephrology 2020, 1 .

AMA Style

Rosilene M. Elias, Sharon Moe, Rosa M. A Moysés. Skeletal and cardiovascular consequences of a positive calcium balance during hemodialysis. Brazilian Journal of Nephrology. 2020; ():1.

Chicago/Turabian Style

Rosilene M. Elias; Sharon Moe; Rosa M. A Moysés. 2020. "Skeletal and cardiovascular consequences of a positive calcium balance during hemodialysis." Brazilian Journal of Nephrology , no. : 1.

Review
Published: 17 March 2020 in Toxins
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Parathyroid hormone (PTH) has an important role in the maintenance of serum calcium levels. It activates renal 1α-hydroxylase and increases the synthesis of the active form of vitamin D (1,25[OH]2D3). PTH promotes calcium release from the bone and enhances tubular calcium resorption through direct action on these sites. Hallmarks of secondary hyperparathyroidism associated with chronic kidney disease (CKD) include increase in serum fibroblast growth factor 23 (FGF-23), reduction in renal 1,25[OH]2D3 production with a decline in its serum levels, decrease in intestinal calcium absorption, and, at later stages, hyperphosphatemia and high levels of PTH. In this paper, we aim to critically discuss severe CKD-related hyperparathyroidism, in which PTH, through calcium-dependent and -independent mechanisms, leads to harmful effects and manifestations of the uremic syndrome, such as bone loss, skin and soft tissue calcification, cardiomyopathy, immunodeficiency, impairment of erythropoiesis, increase of energy expenditure, and muscle weakness.

ACS Style

Eduardo J. Duque; Rosilene M. Elias; Rosa M. A. Moysés. Parathyroid Hormone: A Uremic Toxin. Toxins 2020, 12, 189 .

AMA Style

Eduardo J. Duque, Rosilene M. Elias, Rosa M. A. Moysés. Parathyroid Hormone: A Uremic Toxin. Toxins. 2020; 12 (3):189.

Chicago/Turabian Style

Eduardo J. Duque; Rosilene M. Elias; Rosa M. A. Moysés. 2020. "Parathyroid Hormone: A Uremic Toxin." Toxins 12, no. 3: 189.

Artigo
Published: 01 March 2020 in Brazilian Journal of Nephrology
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Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.

ACS Style

Hanna Karla Andrade Guapyassú Machado; Carolina Steller Wagner Martins; Vanda Jorgetti; Rosilene Motta Elias; Rosa Maria Affonso Moysés. Chronic kidney disease is a main confounding factor for 25-vitamin D measurement. Brazilian Journal of Nephrology 2020, 42, 94 -98.

AMA Style

Hanna Karla Andrade Guapyassú Machado, Carolina Steller Wagner Martins, Vanda Jorgetti, Rosilene Motta Elias, Rosa Maria Affonso Moysés. Chronic kidney disease is a main confounding factor for 25-vitamin D measurement. Brazilian Journal of Nephrology. 2020; 42 (1):94-98.

Chicago/Turabian Style

Hanna Karla Andrade Guapyassú Machado; Carolina Steller Wagner Martins; Vanda Jorgetti; Rosilene Motta Elias; Rosa Maria Affonso Moysés. 2020. "Chronic kidney disease is a main confounding factor for 25-vitamin D measurement." Brazilian Journal of Nephrology 42, no. 1: 94-98.

Nephrology original paper
Published: 03 February 2020 in International Urology and Nephrology
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Hypokalemia is a well-described electrolyte disturbance in patients on peritoneal dialysis (PD). Hyperkalemia, however, is still overlooked, although it also represents a risk factor for mortality. Angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers (ACE/ARB), diuretics, and proton pump inhibitor (PPI) can interfere with potassium levels in these patients. This is a retrospective study that evaluated monthly serum potassium in a 5-year period. Serum potassium disturbances were evaluated as time-average and number of hypo- and hyperkalemia episodes per patient. Prescribed medication such as ACE/ARB, diuretics, and omeprazole were recorded. We evaluated 2025 potassium measurements obtained from 146 patients on PD. Serum potassium ranged from 2.5 to 8.3 mEq/L with an average of 4.72 ± 0.74 mEq/L. Hypokalemia was found in 59 measurements (2.9%) obtained from 35 patients (23.9%) whereas hyperkalemia was demonstrated in 269 (13.3%) measurements obtained from 74 patients (50.7%). Hypokalemia was associated with low albumin (p = 0.022), and omeprazole use (p = 0.024). Black race was a protector factor (p = 0.031). Omeprazole-associated hypokalemia was seen only in non-anuric patients and remained an independent risk factor even after adjustments. Patients who had hyperkalemia were more likely to be anuric (p = 0.001) and in use of furosemide (p = 0.0001). Hyperkalemia and hypokalemia are very frequent in patients on PD and should be closely monitored. Interventional studies should address the impact of discontinuing omeprazole in the levels of potassium.

ACS Style

Fernanda A. Goncalves; Jessica Santos De Jesus; Lilian Cordeiro; Maria Clara T. Piraciaba; Luiza K. R. P. De Araujo; Carolina Steller Wagner Martins; Maria Aparecida Dalboni; Benedito J. Pereira; Bruno Silva; Rosa Maria A. Moysés; Hugo Abensur; Rosilene M. Elias. Hypokalemia and hyperkalemia in patients on peritoneal dialysis: incidence and associated factors. International Urology and Nephrology 2020, 52, 393 -398.

AMA Style

Fernanda A. Goncalves, Jessica Santos De Jesus, Lilian Cordeiro, Maria Clara T. Piraciaba, Luiza K. R. P. De Araujo, Carolina Steller Wagner Martins, Maria Aparecida Dalboni, Benedito J. Pereira, Bruno Silva, Rosa Maria A. Moysés, Hugo Abensur, Rosilene M. Elias. Hypokalemia and hyperkalemia in patients on peritoneal dialysis: incidence and associated factors. International Urology and Nephrology. 2020; 52 (2):393-398.

Chicago/Turabian Style

Fernanda A. Goncalves; Jessica Santos De Jesus; Lilian Cordeiro; Maria Clara T. Piraciaba; Luiza K. R. P. De Araujo; Carolina Steller Wagner Martins; Maria Aparecida Dalboni; Benedito J. Pereira; Bruno Silva; Rosa Maria A. Moysés; Hugo Abensur; Rosilene M. Elias. 2020. "Hypokalemia and hyperkalemia in patients on peritoneal dialysis: incidence and associated factors." International Urology and Nephrology 52, no. 2: 393-398.

Journal article
Published: 14 October 2019 in Clinical Nutrition
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ACS Style

Luana Cristina A. Silva; Maria Aparecida Dalboni; Rosilene M. Elias. Extracellular mass to body cell mass ratio in patients on peritoneal dialysis. Clinical Nutrition 2019, 39, 326 .

AMA Style

Luana Cristina A. Silva, Maria Aparecida Dalboni, Rosilene M. Elias. Extracellular mass to body cell mass ratio in patients on peritoneal dialysis. Clinical Nutrition. 2019; 39 (1):326.

Chicago/Turabian Style

Luana Cristina A. Silva; Maria Aparecida Dalboni; Rosilene M. Elias. 2019. "Extracellular mass to body cell mass ratio in patients on peritoneal dialysis." Clinical Nutrition 39, no. 1: 326.

Original article
Published: 03 October 2019 in Hemodialysis International
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Introduction: Restless legs syndrome (RLS) is a highly prevalent sleep movement disorder usually accompanied by periodic limb movements of sleep (PLMS). The incidence of RLS and PLMS in patients with end‐stage renal disease (ESRD) on dialysis is much higher. Clinically, RLS and PLMS can co‐occur. We hypothesized that patients with ESRD on dialysis would have a distinct presentation of RLS, with a higher prevalence of PLMS. Methods: We examined clinical, demographic, biochemical, and polysomnographic characteristics of RLS in patients on dialysis matched to control subjects with normal renal function based on age, sex, body mass index, and frequency of apneas and hypopneas per hour of sleep, defined by the apnea and hypopnea index (AHI), in a proportion of 3:1. Patients with ESRD were on hemodialysis three times per week. Polysomnography was performed overnight in the sleep laboratory. Findings: Patients on dialysis compared to control subjects had a lower amount of N3 sleep (77.6 ± 39.9 minutes vs. 94.8 ± 33.7 minutes, p = 0.037) and REM sleep (55.6 ± 27.5 minutes vs. 74.1 ± 28.4 minutes, p = 0.006), regardless of the presence of RLS. Among the patients on dialysis, those with RLS had higher PLMS. In the control group, patients with RLS had a lower ferritin level, which was not observed in the dialysis group. There was a significant interaction between PLMS and ESRD (p = 0.001), with a higher prevalence of PLMS in patients with ESRD on dialysis in a model adjusted for AHI, sex, arousals, and age. Factors that were associated with PLMS were RLS (p = 0.003), ESRD (p = 0.0001), and AHI (p = 0.041), with an adjusted R2 of 0.321. Conclusion: RLS in patients with ESRD on dialysis is independently associated with PLMS, regardless of the severity of sleep apnea, arousals, and age.

ACS Style

Beatriz B. M. Bambini; Rosa M. A. Moysés Md; Luci C. D. Batista; Brunelle B. S. S. Coelho; Sergio Tufik; Rosilene M. Elias Md; Fernando M. Coelho Md. Restless legs syndrome in patients on hemodialysis: Polysomnography findings. Hemodialysis International 2019, 23, 445 -448.

AMA Style

Beatriz B. M. Bambini, Rosa M. A. Moysés Md, Luci C. D. Batista, Brunelle B. S. S. Coelho, Sergio Tufik, Rosilene M. Elias Md, Fernando M. Coelho Md. Restless legs syndrome in patients on hemodialysis: Polysomnography findings. Hemodialysis International. 2019; 23 (4):445-448.

Chicago/Turabian Style

Beatriz B. M. Bambini; Rosa M. A. Moysés Md; Luci C. D. Batista; Brunelle B. S. S. Coelho; Sergio Tufik; Rosilene M. Elias Md; Fernando M. Coelho Md. 2019. "Restless legs syndrome in patients on hemodialysis: Polysomnography findings." Hemodialysis International 23, no. 4: 445-448.

Journal article
Published: 20 February 2019 in Scientific Reports
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Dialysate calcium concentration (d[Ca]) might have a cardiovascular impact in patients on haemodialysis (HD) since a higher d[Ca] determines better hemodynamic tolerability. We have assessed the influence of d[Ca] on global longitudinal strain (GLS) by two-dimensional echocardiography using speckle-tracking imaging before and in the last hour of HD. This is an observational crossover study using d[Ca] 1.75 mmol/L and 1.25 mmol/L. Ultrafiltration was the same between interventions; patients aged 44 ± 13 years (N = 19). The 1.75 mmol/L d[Ca] was associated with lighter drop of blood pressure. Post HD serum total calcium was higher with d[Ca] 1.75 than with 1.25 mmol/L (11.5 ± 0.8 vs. 9.1 ± 0.5 mg/dL, respectively, p < 0.01). In almost all segments strain values were significantly worse in the peak HD with 1.75 mmol/L d[Ca] than with 1.25 mmol/L d[Ca]. GLS decreased from −19.8 ± 3.7% at baseline to −17.3 ± 2.9% and −16.1 ± 2.6% with 1.25 d[Ca] and 1.75 d[Ca] mmol/L, respectively (p < 0.05 for both d[Ca] vs. baseline and 1.25 d[Ca] vs. 1.75 d[Ca] mmol/L). Factors associated with a worse GLS included transferrin, C-reactive protein, weight lost, and post dialysis serum total calcium. We concluded that d[Ca] of 1.75 mmol/L was associated with higher post dialysis serum calcium, which contributed to a worse ventricular performance. Whether this finding would lead to myocardial stunning needs further investigation.

ACS Style

V. B. Silva; T. A. Macedo; T. M. S. Braga; B. C. Silva; F. G. Graciolli; W. V. Dominguez; L. F. Drager; R. M. Moysés; R. M. Elias. High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function. Scientific Reports 2019, 9, 2386 .

AMA Style

V. B. Silva, T. A. Macedo, T. M. S. Braga, B. C. Silva, F. G. Graciolli, W. V. Dominguez, L. F. Drager, R. M. Moysés, R. M. Elias. High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function. Scientific Reports. 2019; 9 (1):2386.

Chicago/Turabian Style

V. B. Silva; T. A. Macedo; T. M. S. Braga; B. C. Silva; F. G. Graciolli; W. V. Dominguez; L. F. Drager; R. M. Moysés; R. M. Elias. 2019. "High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function." Scientific Reports 9, no. 1: 2386.

Original article
Published: 28 January 2019 in Osteoporosis International
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Although chronic kidney disease is associated with other bone disorders, osteoporosis can be found in this context, and it is defined based on bone mineral density (BMD), measured by dual-energy X-ray absorptiometry. As CKD progresses, the percentage of normal BMD decreases, whereas that of osteopenia/osteoporosis increases, mostly due to hip involvement, particularly in patients with reduced renal function. Osteoporosis is a highly prevalent disease in patients with chronic kidney disease (CKD). We investigated the features of bone mineral density (BMD) in patients with assorted kidney diseases and hypothesized that low BMD, as measured by dual-energy X-ray absorptiometry (DXA), would be more prevalent as kidney function decreased and would correlate with biomarkers of mineral and bone disease. DXA obtained from January 1, 2008, to December 31, 2017, clinical, demographic, and biochemical data at the time of image acquisition were recorded. Data from 1172 patients were included in this study (81.3% women, 79.9% white, and 8.1% diabetic). Osteopenia and osteoporosis in at least one site (total hip or spine) were found in 32.7% and 20.0% of patients, respectively. As CKD progressed, the percentage of patients with normal BMD decreased, whereas the percentage of osteopenia and osteoporosis increased, which was mostly due to the total hip involvement, particularly in patients with estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2. Older age and hyperparathyroidism were independent risk factors for osteopenia/osteoporosis at the total hip; female gender, older age, and higher iCa were independently associated with the risk of osteopenia/osteoporosis at the spine. With eGFR > 90 ml/min as reference, the odds ratios for osteoporosis/osteopenia at the hip were 1.51 (95% CI 1.01–2.24) and 1.91 (95% CI 1.13–3.20) for patients with eGFR 30–60 and 15–30 ml/min/1.73 m2, respectively. No CKD stage was significantly associated with the risk of osteoporosis/osteopenia at the spine. Our results highlighted that low BMD in patients with CKD is associated with age and hyperparathyroidism, and affects predominantly the hip.

ACS Style

K. S. Bezerra De Carvalho; R.F.V. Vasco; M.R. Custodio; Vanda Jorgetti; R.M.A. Moysés; R.M. Elias. Chronic kidney disease is associated with low BMD at the hip but not at the spine. Osteoporosis International 2019, 30, 1015 -1023.

AMA Style

K. S. Bezerra De Carvalho, R.F.V. Vasco, M.R. Custodio, Vanda Jorgetti, R.M.A. Moysés, R.M. Elias. Chronic kidney disease is associated with low BMD at the hip but not at the spine. Osteoporosis International. 2019; 30 (5):1015-1023.

Chicago/Turabian Style

K. S. Bezerra De Carvalho; R.F.V. Vasco; M.R. Custodio; Vanda Jorgetti; R.M.A. Moysés; R.M. Elias. 2019. "Chronic kidney disease is associated with low BMD at the hip but not at the spine." Osteoporosis International 30, no. 5: 1015-1023.

Journal article
Published: 14 December 2018 in Kidney and Blood Pressure Research
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In the article by Hu et al., entitled “Peritonitis: Episode Sequence, Microbiological Variation, Risk Factors and Clinical Outcomes in a North China Peritoneal Dialysis Center”, published in Kidney and Blood Pressure Research, 2018; 43: 1573-1584 (DOI: 10.1159/000494443), there is a mistake in one of the authors‘ affiliations and in the correspondence address.

ACS Style

Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila E. Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias; Lara Caldiroli; Francesca Zanoni; Valeria Azzini; Anna Villarini; Roberto Meazza; Piergiorgio Messa; Shiika Watanabe; Daisuke Ichikawa; Takeshi Sugaya; Keiichi Ohata; Kazuho Inoue; Seiko Hoshino; Kenjiro Kimura; Yugo Shibagaki; Libor Kopkan; Sona Kikerlova; Zuzana Huskova; Milos Taborsky; Janusz Sadowski; Frantisek Kolar; Ludek Cervenka; Christina Leibrock; Aleksandra A. Pandyra; Christos Stournaras; Carsten A. Wagner; Michael Föller; Shufen Yang; Rizwanguli Abdulla; Chen Lu; Hwee-Yeong Ng; Yueh-Ting Lee; Wei-Hung Kuo; Pei-Chen Huang; Wei-Chia Lee; Yang Li; Hanhua Ji; Xinwen Jian; Xue Li; Jinsong Chen; Dongrui Cheng; Rong Wang; Wei Wang; Mingchao Zhang; Feng Xu; Jiqiu Wen; Yexin Liu; Yan Zhang; Di Liu; Xia Tan; Xiaofang Tang; Fan Zhang; Ming Xia; Guochun Chen; Liyu He; Letian Zhou; Jindřich Špinar; Jiří Pařenica; Lenka Špinarová; Filip Málek; Monika Špinarová; Ondřej Ludka; Jiří Jarkovský; Klára Benešová; Monika Goldbergová-Pávková; Růžena Lábrová; Dimitrios Nikas; Paulina Lopatowska; Elzbieta Młodawska; Jolanta Malyszko; Hanna Bachorzewska-Gajewska; Slawomir Dobrzycki; Bożena Sobkowicz; Ioannis Goudevenos; Bo Yang; Qi Wang; Rui Wang; Ting Yan; Junhao Lv; Jianyong Wu; Jianghua Chen; Ercilhana G.B. Freitas; Denis F. Souza; Peng Gao; Bo Xu; Panai Song; Xuejing Zhu; Shuguang Yuan; Yashipal S. Kanwar; Ying Zheng; Yong Wang; Shuwen Liu; Jie Wu; Shuwei Duan; Hanyu Zhu; Di Wu; Guangyan Cai. Erratum. Kidney and Blood Pressure Research 2018, 43, 1943 -1943.

AMA Style

Erica Adelina, Benedito J. Pereira, Lilian Cordeiro, Camila E. Rodrigues, Ricardo J. Duarte, Hugo Abensur, Rosilene M. Elias, Lara Caldiroli, Francesca Zanoni, Valeria Azzini, Anna Villarini, Roberto Meazza, Piergiorgio Messa, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Libor Kopkan, Sona Kikerlova, Zuzana Huskova, Milos Taborsky, Janusz Sadowski, Frantisek Kolar, Ludek Cervenka, Christina Leibrock, Aleksandra A. Pandyra, Christos Stournaras, Carsten A. Wagner, Michael Föller, Shufen Yang, Rizwanguli Abdulla, Chen Lu, Hwee-Yeong Ng, Yueh-Ting Lee, Wei-Hung Kuo, Pei-Chen Huang, Wei-Chia Lee, Yang Li, Hanhua Ji, Xinwen Jian, Xue Li, Jinsong Chen, Dongrui Cheng, Rong Wang, Wei Wang, Mingchao Zhang, Feng Xu, Jiqiu Wen, Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová, Dimitrios Nikas, Paulina Lopatowska, Elzbieta Młodawska, Jolanta Malyszko, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Bożena Sobkowicz, Ioannis Goudevenos, Bo Yang, Qi Wang, Rui Wang, Ting Yan, Junhao Lv, Jianyong Wu, Jianghua Chen, Ercilhana G.B. Freitas, Denis F. Souza, Peng Gao, Bo Xu, Panai Song, Xuejing Zhu, Shuguang Yuan, Yashipal S. Kanwar, Ying Zheng, Yong Wang, Shuwen Liu, Jie Wu, Shuwei Duan, Hanyu Zhu, Di Wu, Guangyan Cai. Erratum. Kidney and Blood Pressure Research. 2018; 43 (6):1943-1943.

Chicago/Turabian Style

Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila E. Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias; Lara Caldiroli; Francesca Zanoni; Valeria Azzini; Anna Villarini; Roberto Meazza; Piergiorgio Messa; Shiika Watanabe; Daisuke Ichikawa; Takeshi Sugaya; Keiichi Ohata; Kazuho Inoue; Seiko Hoshino; Kenjiro Kimura; Yugo Shibagaki; Libor Kopkan; Sona Kikerlova; Zuzana Huskova; Milos Taborsky; Janusz Sadowski; Frantisek Kolar; Ludek Cervenka; Christina Leibrock; Aleksandra A. Pandyra; Christos Stournaras; Carsten A. Wagner; Michael Föller; Shufen Yang; Rizwanguli Abdulla; Chen Lu; Hwee-Yeong Ng; Yueh-Ting Lee; Wei-Hung Kuo; Pei-Chen Huang; Wei-Chia Lee; Yang Li; Hanhua Ji; Xinwen Jian; Xue Li; Jinsong Chen; Dongrui Cheng; Rong Wang; Wei Wang; Mingchao Zhang; Feng Xu; Jiqiu Wen; Yexin Liu; Yan Zhang; Di Liu; Xia Tan; Xiaofang Tang; Fan Zhang; Ming Xia; Guochun Chen; Liyu He; Letian Zhou; Jindřich Špinar; Jiří Pařenica; Lenka Špinarová; Filip Málek; Monika Špinarová; Ondřej Ludka; Jiří Jarkovský; Klára Benešová; Monika Goldbergová-Pávková; Růžena Lábrová; Dimitrios Nikas; Paulina Lopatowska; Elzbieta Młodawska; Jolanta Malyszko; Hanna Bachorzewska-Gajewska; Slawomir Dobrzycki; Bożena Sobkowicz; Ioannis Goudevenos; Bo Yang; Qi Wang; Rui Wang; Ting Yan; Junhao Lv; Jianyong Wu; Jianghua Chen; Ercilhana G.B. Freitas; Denis F. Souza; Peng Gao; Bo Xu; Panai Song; Xuejing Zhu; Shuguang Yuan; Yashipal S. Kanwar; Ying Zheng; Yong Wang; Shuwen Liu; Jie Wu; Shuwei Duan; Hanyu Zhu; Di Wu; Guangyan Cai. 2018. "Erratum." Kidney and Blood Pressure Research 43, no. 6: 1943-1943.

Journal article
Published: 14 December 2018 in Kidney and Blood Pressure Research
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In the article by Liu et al., entitled “A Novel Inhibitor of Homodimerization Targeting MyD88 Ameliorates Renal Interstitial Fibrosis by Counteracting TGF-β1-Induced EMT in Vivo and in Vitro”, published in Kidney and Blood Pressure Research, 2018; 43: 1677-1687 (DOI: 10.1159/000494745), there is a mistake in the names and addresses of the corresponding authors.

ACS Style

Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila E. Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias; Lara Caldiroli; Francesca Zanoni; Valeria Azzini; Anna Villarini; Roberto Meazza; Piergiorgio Messa; Shiika Watanabe; Daisuke Ichikawa; Takeshi Sugaya; Keiichi Ohata; Kazuho Inoue; Seiko Hoshino; Kenjiro Kimura; Yugo Shibagaki; Libor Kopkan; Sona Kikerlova; Zuzana Huskova; Milos Taborsky; Janusz Sadowski; Frantisek Kolar; Ludek Cervenka; Christina Leibrock; Aleksandra A. Pandyra; Christos Stournaras; Carsten A. Wagner; Michael Föller; Shufen Yang; Rizwanguli Abdulla; Chen Lu; Hwee-Yeong Ng; Yueh-Ting Lee; Wei-Hung Kuo; Pei-Chen Huang; Wei-Chia Lee; Yang Li; Hanhua Ji; Xinwen Jian; Xue Li; Jinsong Chen; Dongrui Cheng; Rong Wang; Wei Wang; Mingchao Zhang; Feng Xu; Jiqiu Wen; Yexin Liu; Yan Zhang; Di Liu; Xia Tan; Xiaofang Tang; Fan Zhang; Ming Xia; Guochun Chen; Liyu He; Letian Zhou; Jindřich Špinar; Jiří Pařenica; Lenka Špinarová; Filip Málek; Monika Špinarová; Ondřej Ludka; Jiří Jarkovský; Klára Benešová; Monika Goldbergová-Pávková; Růžena Lábrová; Dimitrios Nikas; Paulina Lopatowska; Elzbieta Młodawska; Jolanta Malyszko; Hanna Bachorzewska-Gajewska; Slawomir Dobrzycki; Bożena Sobkowicz; Ioannis Goudevenos; Bo Yang; Qi Wang; Rui Wang; Ting Yan; Junhao Lv; Jianyong Wu; Jianghua Chen; Ercilhana G.B. Freitas; Denis F. Souza; Peng Gao; Bo Xu; Panai Song; Xuejing Zhu; Shuguang Yuan; Yashipal S. Kanwar; Ying Zheng; Yong Wang; Shuwen Liu; Jie Wu; Shuwei Duan; Hanyu Zhu; Di Wu; Guangyan Cai. Erratum. Kidney and Blood Pressure Research 2018, 43, 1944 -1944.

AMA Style

Erica Adelina, Benedito J. Pereira, Lilian Cordeiro, Camila E. Rodrigues, Ricardo J. Duarte, Hugo Abensur, Rosilene M. Elias, Lara Caldiroli, Francesca Zanoni, Valeria Azzini, Anna Villarini, Roberto Meazza, Piergiorgio Messa, Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Libor Kopkan, Sona Kikerlova, Zuzana Huskova, Milos Taborsky, Janusz Sadowski, Frantisek Kolar, Ludek Cervenka, Christina Leibrock, Aleksandra A. Pandyra, Christos Stournaras, Carsten A. Wagner, Michael Föller, Shufen Yang, Rizwanguli Abdulla, Chen Lu, Hwee-Yeong Ng, Yueh-Ting Lee, Wei-Hung Kuo, Pei-Chen Huang, Wei-Chia Lee, Yang Li, Hanhua Ji, Xinwen Jian, Xue Li, Jinsong Chen, Dongrui Cheng, Rong Wang, Wei Wang, Mingchao Zhang, Feng Xu, Jiqiu Wen, Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová, Dimitrios Nikas, Paulina Lopatowska, Elzbieta Młodawska, Jolanta Malyszko, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Bożena Sobkowicz, Ioannis Goudevenos, Bo Yang, Qi Wang, Rui Wang, Ting Yan, Junhao Lv, Jianyong Wu, Jianghua Chen, Ercilhana G.B. Freitas, Denis F. Souza, Peng Gao, Bo Xu, Panai Song, Xuejing Zhu, Shuguang Yuan, Yashipal S. Kanwar, Ying Zheng, Yong Wang, Shuwen Liu, Jie Wu, Shuwei Duan, Hanyu Zhu, Di Wu, Guangyan Cai. Erratum. Kidney and Blood Pressure Research. 2018; 43 (6):1944-1944.

Chicago/Turabian Style

Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila E. Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias; Lara Caldiroli; Francesca Zanoni; Valeria Azzini; Anna Villarini; Roberto Meazza; Piergiorgio Messa; Shiika Watanabe; Daisuke Ichikawa; Takeshi Sugaya; Keiichi Ohata; Kazuho Inoue; Seiko Hoshino; Kenjiro Kimura; Yugo Shibagaki; Libor Kopkan; Sona Kikerlova; Zuzana Huskova; Milos Taborsky; Janusz Sadowski; Frantisek Kolar; Ludek Cervenka; Christina Leibrock; Aleksandra A. Pandyra; Christos Stournaras; Carsten A. Wagner; Michael Föller; Shufen Yang; Rizwanguli Abdulla; Chen Lu; Hwee-Yeong Ng; Yueh-Ting Lee; Wei-Hung Kuo; Pei-Chen Huang; Wei-Chia Lee; Yang Li; Hanhua Ji; Xinwen Jian; Xue Li; Jinsong Chen; Dongrui Cheng; Rong Wang; Wei Wang; Mingchao Zhang; Feng Xu; Jiqiu Wen; Yexin Liu; Yan Zhang; Di Liu; Xia Tan; Xiaofang Tang; Fan Zhang; Ming Xia; Guochun Chen; Liyu He; Letian Zhou; Jindřich Špinar; Jiří Pařenica; Lenka Špinarová; Filip Málek; Monika Špinarová; Ondřej Ludka; Jiří Jarkovský; Klára Benešová; Monika Goldbergová-Pávková; Růžena Lábrová; Dimitrios Nikas; Paulina Lopatowska; Elzbieta Młodawska; Jolanta Malyszko; Hanna Bachorzewska-Gajewska; Slawomir Dobrzycki; Bożena Sobkowicz; Ioannis Goudevenos; Bo Yang; Qi Wang; Rui Wang; Ting Yan; Junhao Lv; Jianyong Wu; Jianghua Chen; Ercilhana G.B. Freitas; Denis F. Souza; Peng Gao; Bo Xu; Panai Song; Xuejing Zhu; Shuguang Yuan; Yashipal S. Kanwar; Ying Zheng; Yong Wang; Shuwen Liu; Jie Wu; Shuwei Duan; Hanyu Zhu; Di Wu; Guangyan Cai. 2018. "Erratum." Kidney and Blood Pressure Research 43, no. 6: 1944-1944.

Observational study
Published: 23 November 2018 in Kidney and Blood Pressure Research
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Background/Aims: Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD. Methods: A prospective and observational study that compared technique survival in a cohort of patients who started either early or planned PD. Early start PD was defined as break-in period from 3 to 14 days with no previous nephrologist follow-up or patient training. Results: A total of 154 patients were included (40 as early start PD), followed by a median time of 381 days. Comparing early vs. planned-start PD, groups were similar concerning age 56 (40; 70) vs. 48 (32; 63) years, p=0.071, body mass index (BMI) 23.3 ± 4.2 vs. 23.8 ± 4.0 kg/m2, p=0.567 and male gender (60 vs. 48%, p=0.201), respectively. Comparing early vs. planned-start groups, there were no differences regarding PD dropout for peritonitis (7.5 vs. 11.4%, p=0.764), catheter dysfunction (12.5 vs. 17.5%, p=0.619) and patient burnout (0 vs. 4.4%, p=0.328), respectively. Less patients in early start group quit PD for peritoneal membrane failure in comparison to planned-start group (2.5 vs. 16.7%, p=0.026). In multivariate cox-regression analysis, the only factors independently associated with technique failure were BMI> 25 kg/m² (p=0.033) and Diabetes Mellitus (p=0.013), whereas no differences regarding early vs. planned-PD start were observed (p=0.184). Conclusion: Despite the adverse scenario for initiating dialysis, early start PD had similar outcomes in comparison to planned-start PD in long-term follow-up.

ACS Style

Bruno C. Silva; Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias. Early Start Peritoneal Dialysis: Technique Survival in Long-Term Follow-Up. Kidney and Blood Pressure Research 2018, 43, 1699 -1705.

AMA Style

Bruno C. Silva, Erica Adelina, Benedito J. Pereira, Lilian Cordeiro, Camila Rodrigues, Ricardo J. Duarte, Hugo Abensur, Rosilene M. Elias. Early Start Peritoneal Dialysis: Technique Survival in Long-Term Follow-Up. Kidney and Blood Pressure Research. 2018; 43 (6):1699-1705.

Chicago/Turabian Style

Bruno C. Silva; Erica Adelina; Benedito J. Pereira; Lilian Cordeiro; Camila Rodrigues; Ricardo J. Duarte; Hugo Abensur; Rosilene M. Elias. 2018. "Early Start Peritoneal Dialysis: Technique Survival in Long-Term Follow-Up." Kidney and Blood Pressure Research 43, no. 6: 1699-1705.

Nephrology original paper
Published: 22 August 2018 in International Urology and Nephrology
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Bone biopsy defines classical diseases that constitute the renal osteodystrophy. There is a recent concern regarding other histological findings that are not appreciated by using the turnover, mineralization, and volume (TMV) classification. Iron (Fe) overload has been considered a new challenge and the real significance of the presence of this metal in bones is not completely elucidated. Therefore, the main goal of the current study was to not only to identify bone Fe, but also correlate its presence with demographic, and biochemical characteristics. This is a cross-sectional analysis of bone biopsies performed in 604 patients on dialysis from 2010 to 2014 in a tertiary academic Hospital. Histomorphometric findings revealed the presence of Fe in 29.1%. Fe was associated with higher levels of serum ferritin and serum calcium. No TMV status was related to Fe bone overload. Our study has highlighted that the presence of Fe in one-third of bone samples has unknown clinical significance. The lack of other contemporary bone biopsy study reporting Fe prevents us from comparison. The findings presented here should be specifically addressed in a future research and will require attention prior to implementation of any clinical guideline. If any proposed treatment, however, would change the bone Fe-related morbidity is undetermined.

ACS Style

Melani R. Custodio; Rosilene M. Elias; Wagner D. Velasquez; Luciene M. Dos Reis; Ivone B. Oliveira; Rosa M. A. Moysés; Aluizio B. Carvalho; Vanda Jorgetti. The unexpected presence of iron in bone biopsies of hemodialysis patients. International Urology and Nephrology 2018, 50, 1907 -1912.

AMA Style

Melani R. Custodio, Rosilene M. Elias, Wagner D. Velasquez, Luciene M. Dos Reis, Ivone B. Oliveira, Rosa M. A. Moysés, Aluizio B. Carvalho, Vanda Jorgetti. The unexpected presence of iron in bone biopsies of hemodialysis patients. International Urology and Nephrology. 2018; 50 (10):1907-1912.

Chicago/Turabian Style

Melani R. Custodio; Rosilene M. Elias; Wagner D. Velasquez; Luciene M. Dos Reis; Ivone B. Oliveira; Rosa M. A. Moysés; Aluizio B. Carvalho; Vanda Jorgetti. 2018. "The unexpected presence of iron in bone biopsies of hemodialysis patients." International Urology and Nephrology 50, no. 10: 1907-1912.

Journal article
Published: 27 April 2018 in BMC Nephrology
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The transition from pre-dialysis chronic kidney disease (CKD) to renal replacement therapy (RRT) is a stressful event. Anxiety, depression and stress are frequent conditions in this population, and might play a role on the choice of dialysis modality. This is a prospective study that included stages 4-5 CKD patients during a dialysis multi-disciplinary education program. Demographic, clinical, and laboratory data were evaluated. Hospital Anxiety and Depression Scale and a Perceived Stress Scale assessed levels of anxiety, depression and stress, respectively. A total of 67 from 190 recruited patients were included (59 ± 15 years, 54% males). Comparing patients who chose peritoneal dialysis (PD) and hemodialysis (HD), there were no differences on anxiety (p = 0.55), and depression scores (p = 0.467), and stress (p = 0.854). Anxious (p = 0.007) and depressive (p = 0.030) patients presented lower levels of phosphate than those not affected. There was a significant correlation (p < 0.0001) between anxiety and depression scores (R2 = 0.573), anxiety and stress scores (R2 = 0.542), depression and stress scores (R2 = 0.514). At the end of study, 29.8% of patients had already started on dialysis, and scores of anxiety, depression and stress reduced significantly (all p values < 0.0001), from 5.9 ± 3.3 to 1.8 ± 1.8, from 7.7 ± 4.0 to 3.8 ± 2.9 and from 28.6 ± 7.8 to 10.0 ± 6.2, respectively, regardless of which therapy was chosen. Depression, anxiety and perceived stress during final stages of CKD do not seem to be related to the choice of dialysis therapy and tend to decrease after dialysis initiation.

ACS Style

Cicero Italo L. Bezerra; Bruno C. Silva; Rosilene M. Elias. Decision-making process in the pre-dialysis CKD patients: do anxiety, stress and depression matter? BMC Nephrology 2018, 19, 1 -6.

AMA Style

Cicero Italo L. Bezerra, Bruno C. Silva, Rosilene M. Elias. Decision-making process in the pre-dialysis CKD patients: do anxiety, stress and depression matter? BMC Nephrology. 2018; 19 (1):1-6.

Chicago/Turabian Style

Cicero Italo L. Bezerra; Bruno C. Silva; Rosilene M. Elias. 2018. "Decision-making process in the pre-dialysis CKD patients: do anxiety, stress and depression matter?" BMC Nephrology 19, no. 1: 1-6.