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Molecular imprinted polymers are a promising alternative to natural receptors due to their higher stability and lower production costs, yet with comparable performance and high selectivity. The ‘epitope imprinting approach‘, in which only a small sub-unit of the target is used as the template during imprinting provides a solution to overcome several limitations characteristic for biomacromolecular imprinting including availability, complexity, size, and conformational flexibility associated with biomacromolecules. The present review summarizes recent strategies for epitope imprinting, and highlights the applicability of this approach to a wide range of targets with different sizes and molecular properties including proteins, biomarkers and viruses.
Sandra Dietl; Harald Sobek; Boris Mizaikoff. Epitope-Imprinted Polymers for Biomacromolecules: Recent Strategies, Future Challenges and Selected Applications. TrAC Trends in Analytical Chemistry 2021, 116414 .
AMA StyleSandra Dietl, Harald Sobek, Boris Mizaikoff. Epitope-Imprinted Polymers for Biomacromolecules: Recent Strategies, Future Challenges and Selected Applications. TrAC Trends in Analytical Chemistry. 2021; ():116414.
Chicago/Turabian StyleSandra Dietl; Harald Sobek; Boris Mizaikoff. 2021. "Epitope-Imprinted Polymers for Biomacromolecules: Recent Strategies, Future Challenges and Selected Applications." TrAC Trends in Analytical Chemistry , no. : 116414.
The ongoing COVID-19 pandemic represents a considerable risk for the general public and especially for health care workers. To avoid an overloading of the health care system and to control transmission chains, the development of rapid and cost-effective techniques allowing for the reliable diagnosis of individuals with acute respiratory infections are crucial. Uniquely, the present study focuses on a direct face mask sampling approach, as worn (i.e., used) disposable face masks contain exogenous environmental constituents, as well as endogenously exhaled breath aerosols. Optical techniques – and specifically infrared (IR) molecular spectroscopic techniques - are promising tools for direct virus detection at the surface of such masks. In the present study, a rapid and non-destructive approach for monitoring exposure scenarios via medical face masks using attenuated total reflection infrared spectroscopy is presented. Complementarily, IR external reflection spectroscopy was evaluated in comparison for rapid mask analysis. The utility of a face mask-based sampling approach was demonstrated by differentiating water, proteins, and virus-like particles sampled onto the mask. Data analysis using multivariate statistical algorithms enabled unambiguously classifying spectral signatures of individual components and biospecies. This approach readily extends towards the rapid detection of SARS-CoV-2 – as shown herein for the example of virus-like particles which are morphologically equivalent to authentic virus - without any additional sample preparation or elaborate testing equipment at laboratory facilities. Therefore, this strategy may be implemented as a routine large-scale monitoring routine, e.g., at health care institutions, nursing homes, etc. ensuring the health and safety of medical personnel.
Vanessa Schorer; Julian Haas; Robert Stach; Vjekoslav Kokoric; Rüdiger Groß; Jan Münch; Tim Hummel; Harald Sobek; Jan Mennig; Boris Mizaikoff. Towards the Direct Detection of Viral Materials at the Surface of Protective Face Masks via Infrared Spectroscopy. 2021, 1 .
AMA StyleVanessa Schorer, Julian Haas, Robert Stach, Vjekoslav Kokoric, Rüdiger Groß, Jan Münch, Tim Hummel, Harald Sobek, Jan Mennig, Boris Mizaikoff. Towards the Direct Detection of Viral Materials at the Surface of Protective Face Masks via Infrared Spectroscopy. . 2021; ():1.
Chicago/Turabian StyleVanessa Schorer; Julian Haas; Robert Stach; Vjekoslav Kokoric; Rüdiger Groß; Jan Münch; Tim Hummel; Harald Sobek; Jan Mennig; Boris Mizaikoff. 2021. "Towards the Direct Detection of Viral Materials at the Surface of Protective Face Masks via Infrared Spectroscopy." , no. : 1.
Steroid hormones are active substances that are necessary in the normal functioning of all physiological activities in the body, such as sexual characteristics, metabolism, and mood control. They are also widely used as exogenous chemicals in medical and pharmaceutical applications as treatments and at times growth promoters in animal farming. The vast application of steroid hormones has resulted in them being found in different matrices, such as food, environmental, and biological samples. The presence of hormones in such matrices means that they can easily come into contact with humans and animals as exogenous compounds, resulting in abnormal concentrations that can lead to endocrine disruption. This makes their determination in different matrices a vital part of pollutant management and control. Although advances in analytical instruments are constant, it has been determined that these instruments still require some sample preparation steps to be able to determine the occurrence of pollutants in the complex matrices in which they occur. Advances are still being made in sample preparation to ensure easier, selective, and sensitive analysis of complex matrices. Molecularly imprinted polymers (MIPs) have been termed as advanced solid-phase (SPE) materials for the selective extraction and preconcentration of hormones in complex matrices. This review explores the preparation and application of MIPs for the determination of steroid hormones in different sample types.
Anele Mpupa; Shirley Selahle; Boris Mizaikoff; Philiswa Nomngongo. Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones. Chemosensors 2021, 9, 151 .
AMA StyleAnele Mpupa, Shirley Selahle, Boris Mizaikoff, Philiswa Nomngongo. Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones. Chemosensors. 2021; 9 (7):151.
Chicago/Turabian StyleAnele Mpupa; Shirley Selahle; Boris Mizaikoff; Philiswa Nomngongo. 2021. "Recent Advances in Solid-Phase Extraction (SPE) Based on Molecularly Imprinted Polymers (MIPs) for Analysis of Hormones." Chemosensors 9, no. 7: 151.
Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment consists of classifying breath samples from 15 subjects before and after eating a specific meal using three instruments. We investigate the possibility to transfer calibration models across instruments using transfer samples from the experiment under study, since representative samples of human breath at some conditions are difficult to simulate in a laboratory. For example, exhaled breath from subjects suffering from a disease for which the biomarkers are mostly unknown. Results show that many transfer samples of all the classes under study (in our case meal/no meal) are needed, although some CT methods present reasonably good results with only one class.
Carsten Jaeschke; Marta Padilla; Johannes Glöckler; Inese Polaka; Martins Leja; Viktors Veliks; Jan Mitrovics; Marcis Leja; Boris Mizaikoff. Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies. Molecules 2021, 26, 3776 .
AMA StyleCarsten Jaeschke, Marta Padilla, Johannes Glöckler, Inese Polaka, Martins Leja, Viktors Veliks, Jan Mitrovics, Marcis Leja, Boris Mizaikoff. Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies. Molecules. 2021; 26 (12):3776.
Chicago/Turabian StyleCarsten Jaeschke; Marta Padilla; Johannes Glöckler; Inese Polaka; Martins Leja; Viktors Veliks; Jan Mitrovics; Marcis Leja; Boris Mizaikoff. 2021. "Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies." Molecules 26, no. 12: 3776.
The Cover Feature shows an ionic carbon nitride photoanode capable of bias‐free photoreforming of alcohols to hydrogen. More information can be found in the Full Paper by C. Adler et al.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía dos Santos‐Gómez; Santiago García‐Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Cover Feature: Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes (ChemSusChem 10/2021). ChemSusChem 2021, 14, 2142 -2142.
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía dos Santos‐Gómez, Santiago García‐Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Cover Feature: Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes (ChemSusChem 10/2021). ChemSusChem. 2021; 14 (10):2142-2142.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía dos Santos‐Gómez; Santiago García‐Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2021. "Cover Feature: Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes (ChemSusChem 10/2021)." ChemSusChem 14, no. 10: 2142-2142.
The mineralogical complexity of mine dust complicates exposure monitoring methods for occupational, respirable hazards. Improved understanding of the variability in respirable dust characteristics, e.g., mineral phase occurrence and composition, is required to advance on-site monitoring techniques that can be applied across diverse mining sectors. Principal components analysis (PCA) models were applied separately to XRD and FTIR datasets collected on 130 respirable dust samples from seven mining commodities to explore similarities and differences among the samples. Findings from both PCA models classified limestone, iron, and granite mine samples via their analytical responses. However, the results also cautioned that respirable samples from these commodities may not always fit patterns observed within the model. For example, one unique sample collected in a limestone mine contained no carbonate minerals. Future predictive quantification models should account for unique samples. Differences between gold and copper mine dust samples were difficult to observe. Further investigation suggested that the key to their differentiation by FTIR may lie in the characterization of clays. The results presented in this study provide foundational information for guiding the development of quantification models for respirable mineral hazards in the mining industry.
Rachel Walker; Emanuele Cauda; Lauren Chubb; Patrick Krebs; Robert Stach; Boris Mizaikoff; Cliff Johnston. Complexity of Respirable Dust Found in Mining Operations as Characterized by X-ray Diffraction and FTIR Analysis. Minerals 2021, 11, 383 .
AMA StyleRachel Walker, Emanuele Cauda, Lauren Chubb, Patrick Krebs, Robert Stach, Boris Mizaikoff, Cliff Johnston. Complexity of Respirable Dust Found in Mining Operations as Characterized by X-ray Diffraction and FTIR Analysis. Minerals. 2021; 11 (4):383.
Chicago/Turabian StyleRachel Walker; Emanuele Cauda; Lauren Chubb; Patrick Krebs; Robert Stach; Boris Mizaikoff; Cliff Johnston. 2021. "Complexity of Respirable Dust Found in Mining Operations as Characterized by X-ray Diffraction and FTIR Analysis." Minerals 11, no. 4: 383.
In spite of the enormous promise that polymeric carbon nitride (PCN) materials hold for various applications, the fabrication of high‐quality, binder‐free PCN films and electrodes has been a largely elusive goal to date. Here we tackle this challenge by devising, for the first time, a water‐based sol–gel approach that enables facile preparation of thin films based on poly(heptazine imide) (PHI), a polymer belonging to the PCN family. The sol–gel process capitalizes on the use of a water‐soluble PHI precursor that allows formation of a non‐covalent hydrogel. The hydrogel can be deposited on conductive substrates resulting in formation of mechanically stable polymeric thin layers. The resulting photoanodes exhibit unprecedented photoelectrochemical (PEC) performance in alcohol reforming and highly selective (~100%) conversions with very high photocurrents (>0.25 mA cm –2 under 2 sun) down to <0 V vs. RHE. This enables even effective PEC operation under zero‐bias conditions, and represents the very first example of a ‘soft matter’‐based PEC system capable of bias‐free photoreforming. The robust binder‐free films derived from sol–gel processing of water‐soluble PCN thus constitute a new paradigm for high‐performance ‘soft matter’ photoelectrocatalytic systems, and pave the way for further applications in which high‐quality PCN films are required.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Santos‐Gómez; Santiago García‐Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes**. ChemSusChem 2021, 14, 2170 -2179.
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía Santos‐Gómez, Santiago García‐Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes**. ChemSusChem. 2021; 14 (10):2170-2179.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Santos‐Gómez; Santiago García‐Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2021. "Sol−Gel Processing of Water‐Soluble Carbon Nitride Enables High‐Performance Photoanodes**." ChemSusChem 14, no. 10: 2170-2179.
The presence of endocrine disruptors in surface waters can have negative implications on wildlife and humans both directly and indirectly. A molecularly imprinted polymer (MIP) was explored for its potential to enhance the UV-Vis determination of trenbolone in water using solid-phase extraction (SPE). The synthesized MIP was studied using Fourier transform infrared spectra (FTIR) and scanning electron microscopy (SEM). Using the MIP resulted in a preconcentration and enrichment factor of 14 and 8, respectively. Trenbolone binding on the MIP was shown to follow a Langmuir adsorption and had a maximum adsorption capacity of 27.5 mg g−1. Interference studies showed that the MIP selectivity was not compromised by interferences in the sample. The MIP could be recycled three times before significant loss in analyte recovery.
Anele Mpupa; Mehmet Dinc; Boris Mizaikoff; Philiswa Nosizo Nomngongo. Exploration of a Molecularly Imprinted Polymer (MIPs) as an Adsorbent for the Enrichment of Trenbolone in Water. Processes 2021, 9, 186 .
AMA StyleAnele Mpupa, Mehmet Dinc, Boris Mizaikoff, Philiswa Nosizo Nomngongo. Exploration of a Molecularly Imprinted Polymer (MIPs) as an Adsorbent for the Enrichment of Trenbolone in Water. Processes. 2021; 9 (2):186.
Chicago/Turabian StyleAnele Mpupa; Mehmet Dinc; Boris Mizaikoff; Philiswa Nosizo Nomngongo. 2021. "Exploration of a Molecularly Imprinted Polymer (MIPs) as an Adsorbent for the Enrichment of Trenbolone in Water." Processes 9, no. 2: 186.
Immune cell activation leads to the acquisition of new functions, such as proliferation, chemotaxis, and cytokine production. These functional changes require continuous metabolic adaption in order to sustain ATP homeostasis for sufficient host defense. The bioenergetic demands are usually met by the interconnected metabolic pathways glycolysis, TCA cycle, and oxidative phosphorylation. Apart from glucose, other sources, such as fatty acids and glutamine, are able to fuel the TCA cycle.Rising evidence has shown that cellular metabolism has a direct effect on the regulation of immune cell functions. Thus, quiescent immune cells maintain a basal metabolic state, which shifts to an accelerated metabolic level upon immune cell activation in order to promote key effector functions.This review article summarizes distinct metabolic signatures of key immune cell subsets from quiescence to activation and demonstrates a methodical concept of how to assess cellular metabolic pathways. It further discusses why metabolic functions are of rising interest for translational research and how they can be affected by the underlying pathophysiological condition and/or therapeutic interventions.
Xiaomin Zhang; Fabian Zink; Felix Hezel; Josef Vogt; Ulrich Wachter; Martin Wepler; Maurizio Loconte; Christine Kranz; Andreas Hellmann; Boris Mizaikoff; Peter Radermacher; Clair Hartmann. Metabolic substrate utilization in stress-induced immune cells. Intensive Care Medicine Experimental 2020, 8, 1 -14.
AMA StyleXiaomin Zhang, Fabian Zink, Felix Hezel, Josef Vogt, Ulrich Wachter, Martin Wepler, Maurizio Loconte, Christine Kranz, Andreas Hellmann, Boris Mizaikoff, Peter Radermacher, Clair Hartmann. Metabolic substrate utilization in stress-induced immune cells. Intensive Care Medicine Experimental. 2020; 8 (1):1-14.
Chicago/Turabian StyleXiaomin Zhang; Fabian Zink; Felix Hezel; Josef Vogt; Ulrich Wachter; Martin Wepler; Maurizio Loconte; Christine Kranz; Andreas Hellmann; Boris Mizaikoff; Peter Radermacher; Clair Hartmann. 2020. "Metabolic substrate utilization in stress-induced immune cells." Intensive Care Medicine Experimental 8, no. 1: 1-14.
In spite of the enormous promise that polymeric carbon nitride (PCN) materials hold for various applications, the fabrication of high-quality, binder-free PCN films and electrodes has been a largely elusive goal to date. Here we tackle this challenge by devising, for the first time, a sol–gel approach that enables facile preparation of thin films based on poly(heptazine imide) (PHI), a polymer belonging to the PCN family. The sol–gel process capitalizes on the use of a water-soluble PHI precursor that allows formation of a non-covalent hydrogel. The hydrogel can be deposited on conductive substrates resulting in formation of mechanically stable polymeric thin layers. The resulting photoanodes exhibit unprecedented PEC performance in alcohol reforming and selective (~100%) conversions with very high photocurrents down to ~0 V vs. RHE, which enables even effective operation under bias-free conditions. The robust binder-free films derived from sol–gel processing of water-soluble PCN thus represent a new paradigm for high-performance ‘soft-matter’ photoelectrocatalytic systems, and pave the way for further applications in which high-quality PCN films are required.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. 2020, 1 .
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía Dos Santos-Gómez, Santiago García-Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. . 2020; ():1.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2020. "Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes." , no. : 1.
In spite of the enormous promise that polymeric carbon nitride (PCN) materials hold for photoelectrochemical (PEC) applications, the fabrication of highly stable and photoactive PCN photoelectrodes has been a largely elusive goal to date. Here we tackle this challenge by devising, for the first time, a sol–gel approach that enables facile preparation of photoanodes based on poly(heptazine imide) (PHI), a polymer belonging to the PCN family. The sol–gel process capitalizes on the use of a water-soluble PHI precursor composed of nanosized (~10 nm) particles that allows formation of a non-covalent hydrogel. The hydrogel can be deposited on a conductive substrate resulting in formation of mechanically stable porous polymeric thin layers (~400 nm), in contrast to the commonly obtained loosely attached thick particulate coatings. The resulting photoanodes exhibit unprecedented PEC performance in methanol reforming in neutral pH electrolytes with very high photocurrents of 177±27 mA (1 sun illumination) cm-2 and 320±40 mA cm-2 (2 sun illumination) at 1.23 V vs. RHE, with very high photocurrents down to ~0 V vs. RHE. These parameters permit effective operation even without any external electric bias, as demonstrated by zero-bias photoreforming of methanol and glycerol, and highly selective (~100%) photooxidation of 4-methoxybenzyl alcohol (4-MBA). The robust binder-free films derived from sol–gel processing of water-soluble PCN thus represent a new paradigm for high-performance ‘soft-matter’ photoelectrocatalytic systems based on PCN.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. 2020, 1 .
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía Dos Santos-Gómez, Santiago García-Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. . 2020; ():1.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2020. "Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes." , no. : 1.
In spite of the enormous promise that polymeric carbon nitride (PCN) materials hold for photoelectrochemical (PEC) applications, the fabrication of high-quality PCN photoelectrodes has been a largely elusive goal to date. Here we tackle this challenge by devising, for the first time, a sol–gel approach that enables facile preparation of photoanodes based on poly(heptazine imide) (PHI), a polymer belonging to the PCN family. The sol–gel process capitalizes on the use of a water-soluble PHI precursor composed of nanosized (~10 nm) particles that allows formation of a non-covalent hydrogel. The hydrogel can be deposited on a conductive substrate resulting in formation of mechanically stable porous polymeric thin layers (~400 nm), in contrast to the commonly obtained loosely attached thick particulate coatings. The resulting photoanodes exhibit unprecedented PEC performance in methanol reforming in neutral pH electrolytes with photocurrents of up to 177±27 mA cm-2 (1 sun illumination) and 320±40 mA cm-2 (2 sun illumination) at 1.23 V vs. RHE, maintaining such high photocurrents even down to ~0 V vs. RHE. These parameters permit effective operation even without any external electric bias, as demonstrated by bias-free photoreforming of methanol and glycerol, and highly selective (~100%) photooxidation of 4-methoxybenzyl alcohol (4-MBA). The robust binder-free films derived from sol–gel processing of water-soluble PCN thus represent a new paradigm for high-performance ‘soft-matter’ photoelectrocatalytic systems, and pave the way for further applications in which high-quality PCN films are required.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. 2020, 1 .
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía Dos Santos-Gómez, Santiago García-Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. . 2020; ():1.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2020. "Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes." , no. : 1.
Although we have recently reported the involvement of neonatal Fc receptor (FcRn) in intranasal transport, the transport mechanisms are far from being elucidated. Ex vivo porcine olfactory tissue, primary cells from porcine olfactory epithelium (OEPC) and the human cell line RPMI 2650 were used to evaluate the permeation of porcine and human IgG antibodies through the nasal mucosa. IgGs were used in their wild type and deglycosylated form to investigate the impact of glycosylation. Further, the expression of FcRn and Fc-gamma receptor (FCGR) and their interaction with IgG were analyzed. Comparable permeation rates for human and porcine IgG were observed in OEPC, which display the highest expression of FcRn. Only traces of porcine IgGs could be recovered at the basolateral compartment in ex vivo olfactory tissue, while human IgGs reached far higher levels. Deglycosylated human IgG showed significantly higher permeation in comparison to the wild type in RPMI 2650 and OEPC, but insignificantly elevated in the ex vivo model. An immunoprecipitation with porcine primary cells and tissue identified FCGR2 as a potential interaction partner in the nasal mucosa. Glycosylation sensitive receptors appear to be involved in the uptake, transport, but also degradation of therapeutic IgGs in the airway epithelial layer.
Simone Ladel; Frank Maigler; Johannes Flamm; Patrick Schlossbauer; Alina Handl; Rebecca Hermann; Helena Herzog; Thomas Hummel; Boris Mizaikoff; Katharina Schindowski. Impact of Glycosylation and Species Origin on the Uptake and Permeation of IgGs through the Nasal Airway Mucosa. Pharmaceutics 2020, 12, 1014 .
AMA StyleSimone Ladel, Frank Maigler, Johannes Flamm, Patrick Schlossbauer, Alina Handl, Rebecca Hermann, Helena Herzog, Thomas Hummel, Boris Mizaikoff, Katharina Schindowski. Impact of Glycosylation and Species Origin on the Uptake and Permeation of IgGs through the Nasal Airway Mucosa. Pharmaceutics. 2020; 12 (11):1014.
Chicago/Turabian StyleSimone Ladel; Frank Maigler; Johannes Flamm; Patrick Schlossbauer; Alina Handl; Rebecca Hermann; Helena Herzog; Thomas Hummel; Boris Mizaikoff; Katharina Schindowski. 2020. "Impact of Glycosylation and Species Origin on the Uptake and Permeation of IgGs through the Nasal Airway Mucosa." Pharmaceutics 12, no. 11: 1014.
In spite of the enormous promise that polymeric carbon nitride (PCN) materials hold for photoelectrochemical (PEC) applications, the fabrication of highly stable and photoactive PCN photoelectrodes has been a largely elusive goal to date. Here we tackle this challenge by devising, for the first time, a sol–gel approach that enables facile preparation of photoanodes based on poly(heptazine imide) (PHI), a polymer belonging to the PCN family. The sol–gel process capitalizes on the use of a water-soluble PHI precursor composed of nanosized (~10 nm) particles that allows formation of a non-covalent hydrogel. The hydrogel can be deposited on a conductive substrate resulting in formation of mechanically stable porous polymeric thin layers (~400 nm), in contrast to the commonly obtained loosely attached thick particulate coatings. The resulting photoanodes exhibit unprecedented PEC performance in methanol reforming in neutral pH electrolytes with very high photocurrents of 177±27 mA (1 sun illumination) cm-2 and 320±40 mA cm-2 (2 sun illumination) at 1.23 V vs. RHE, with very high photocurrents down to ~0 V vs. RHE. These parameters permit effective operation even without any external electric bias, as demonstrated by zero-bias photoreforming of methanol and glycerol, and highly selective (~100%) photooxidation of 4-methoxybenzyl alcohol (4-MBA). The robust binder-free films derived from sol–gel processing of water-soluble PCN thus represent a new paradigm for high-performance ‘soft-matter’ photoelectrocatalytic systems based on PCN.
Christiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. 2020, 1 .
AMA StyleChristiane Adler, Igor Krivtsov, Dariusz Mitoraj, Lucía Dos Santos-Gómez, Santiago García-Granda, Christof Neumann, Julian Kund, Christine Kranz, Boris Mizaikoff, Andrey Turchanin, Radim Beranek. Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes. . 2020; ():1.
Chicago/Turabian StyleChristiane Adler; Igor Krivtsov; Dariusz Mitoraj; Lucía Dos Santos-Gómez; Santiago García-Granda; Christof Neumann; Julian Kund; Christine Kranz; Boris Mizaikoff; Andrey Turchanin; Radim Beranek. 2020. "Sol–Gel Processing of Water-Soluble Carbon Nitride Enables High-Performance Photoanodes." , no. : 1.
In the presented study, the possibility of drift counteraction using component removal methods performing drift correction is explored by utilising our recently demonstrated innovative eNose concept, the so-called iLovEnose system.
Carsten Jaeschke; Johannes Glöckler; Marta Padilla; Jan Mitrovics; Boris Mizaikoff. An eNose-based method performing drift correction for online VOC detection under dry and humid conditions. Analytical Methods 2020, 12, 4724 -4733.
AMA StyleCarsten Jaeschke, Johannes Glöckler, Marta Padilla, Jan Mitrovics, Boris Mizaikoff. An eNose-based method performing drift correction for online VOC detection under dry and humid conditions. Analytical Methods. 2020; 12 (39):4724-4733.
Chicago/Turabian StyleCarsten Jaeschke; Johannes Glöckler; Marta Padilla; Jan Mitrovics; Boris Mizaikoff. 2020. "An eNose-based method performing drift correction for online VOC detection under dry and humid conditions." Analytical Methods 12, no. 39: 4724-4733.
Infrared spectroscopy enables insight into light‐activated riboflavin‐induced collagen cross‐linking for future intervertebral disc treatment and repair. Further details can be found in the article by Ioannis Vasilikos, Julian Haas, Graciosa Q. Teixeira, Julia Nothelfer, Cornelia Neidlinger‐Wilke, Hans‐Joachim Wilke, Andreas Seitz, Demetrios G. Vavvas, Josef Zentner, Jürgen Beck, Ulrich Hubbe, and Boris Mizaikoff (e202000110).
Ioannis Vasilikos; Julian Haas; Graciosa Q. Teixeira; Julia Nothelfer; Cornelia Neidlinger‐Wilke; Hans‐Joachim Wilke; Andreas Seitz; Demetrios G. Vavvas; Josef Zentner; Jürgen Beck; Ulrich Hubbe; Boris Mizaikoff. Front Cover. Journal of Biophotonics 2020, 13, 1 .
AMA StyleIoannis Vasilikos, Julian Haas, Graciosa Q. Teixeira, Julia Nothelfer, Cornelia Neidlinger‐Wilke, Hans‐Joachim Wilke, Andreas Seitz, Demetrios G. Vavvas, Josef Zentner, Jürgen Beck, Ulrich Hubbe, Boris Mizaikoff. Front Cover. Journal of Biophotonics. 2020; 13 (10):1.
Chicago/Turabian StyleIoannis Vasilikos; Julian Haas; Graciosa Q. Teixeira; Julia Nothelfer; Cornelia Neidlinger‐Wilke; Hans‐Joachim Wilke; Andreas Seitz; Demetrios G. Vavvas; Josef Zentner; Jürgen Beck; Ulrich Hubbe; Boris Mizaikoff. 2020. "Front Cover." Journal of Biophotonics 13, no. 10: 1.
Bare gold nanoparticles were embedded into an iron-polyoxovanadate matrix and used to enhance both the infrared and Raman signatures of a model analyte. A detailed characterization of the matrix-embedded nanoparticles revealed that they retained a plasmon resonance at 564 nm. The enhancement of vibrational signatures of the model analyte crystal violet using bare and embedded gold nanoparticles was compared for both surface enhanced infrared (SEIRA) spectroscopy and surface enhanced Raman spectroscopy (SERS) yielding enhancement factors of 2.2 for SEIRA and 77 for SERS. In contrast, the bare gold nanoparticles revealed significantly lower enhancements (1.6 for SEIRA; 20 for SERS). Hence, it was shown that embedding nanoparticles within an inorganic polyoxometalate-based matrix is an innovative strategy to amplify their signal enhancement properties in vibrational spectroscopies.
Stefan Repp; Ángela I. Lopez-Lorente; Boris Mizaikoff; Carsten Streb. Hybrid Gold Nanoparticle–Polyoxovanadate Matrices: A Novel Surface Enhanced Raman/Surface Enhanced Infrared Spectroscopy Substrate. ACS Omega 2020, 5, 25036 -25041.
AMA StyleStefan Repp, Ángela I. Lopez-Lorente, Boris Mizaikoff, Carsten Streb. Hybrid Gold Nanoparticle–Polyoxovanadate Matrices: A Novel Surface Enhanced Raman/Surface Enhanced Infrared Spectroscopy Substrate. ACS Omega. 2020; 5 (39):25036-25041.
Chicago/Turabian StyleStefan Repp; Ángela I. Lopez-Lorente; Boris Mizaikoff; Carsten Streb. 2020. "Hybrid Gold Nanoparticle–Polyoxovanadate Matrices: A Novel Surface Enhanced Raman/Surface Enhanced Infrared Spectroscopy Substrate." ACS Omega 5, no. 39: 25036-25041.
A surfactant-free method was used to synthesize iron oxyhydroxide (akaganeite, β-FeOOH) nanorods and characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM-EDS), and transmission electron microscopy (TEM). The synthesized nanoadsorbent was applied for the adsorptive removal of β-estradiol from aqueous solutions. The parameters affecting the adsorption were optimized using a multivariate approach based on the Box–Behnken design with the desirability function. Under the optimum conditions, the equilibrium data were investigated using two and three parameter isotherms, such as the Langmuir, Freundlich, Dubinin–Radushkevich, Redlich–Peterson, and Sips models. The adsorption data were described as Langmuir and Sips isotherm models and the maximum adsorption capacities in Langmuir and Sips of the β-FeOOH nanorods were 97.0 and 103 mg g−1, respectively. The adjusted non-linear adsorption capacities were 102 and 104 mg g−1 for Langmuir and Sips, respectively. The kinetics data were analyzed by five different kinetic models, such as the pseudo-first order, pseudo-second order, intraparticle, as well as Boyd and Elovich models. The method was applied for the removal β-estradiol in spiked recoveries of wastewater, river, and tap water samples, and the removal efficiency ranged from 93–100%. The adsorbent could be reused up to six times after regeneration with acetonitrile without an obvious loss in the removal efficiency (%RE = 95.4 ± 1.9%). Based on the results obtained, it was concluded that the β-FeOOH nanorods proved to be suitable for the efficient removal of β-estradiol from environmental matrices.
Anele Mpupa; Azile Nqombolo; Boris Mizaikoff; Philiswa Nosizo Nomngongo. Enhanced Adsorptive Removal of β-Estradiol from Aqueous and Wastewater Samples by Magnetic Nano-Akaganeite: Adsorption Isotherms, Kinetics, and Mechanism. Processes 2020, 8, 1197 .
AMA StyleAnele Mpupa, Azile Nqombolo, Boris Mizaikoff, Philiswa Nosizo Nomngongo. Enhanced Adsorptive Removal of β-Estradiol from Aqueous and Wastewater Samples by Magnetic Nano-Akaganeite: Adsorption Isotherms, Kinetics, and Mechanism. Processes. 2020; 8 (9):1197.
Chicago/Turabian StyleAnele Mpupa; Azile Nqombolo; Boris Mizaikoff; Philiswa Nosizo Nomngongo. 2020. "Enhanced Adsorptive Removal of β-Estradiol from Aqueous and Wastewater Samples by Magnetic Nano-Akaganeite: Adsorption Isotherms, Kinetics, and Mechanism." Processes 8, no. 9: 1197.
Ferrous objects, especially those that are additionally exposed to harsh environments, e.g., high humidity, have the common problem of suffering aggressive corrosion processes. Without a precaution, this leads in many cases to a limited functionality followed by treatment steps, and expensive repairing costs, as well as to defects/uselessness and even to safety problems, e.g., bridge-collapsing, escaping gas and liquids from pipelines, or leaking oil tankers destroying the ecological system. Conventionally applied methods are confined to laboratory use due to bulky instruments, and are, therefore, time-intensive and may cause erroneous results. Therefore, a sensor based on fiber-optic evanescent wave spectroscopy (FEWS) working in the visible spectral range was developed. The sensor system is comprised of an uncoated single crystal sapphire fiber as a waveguide operating in the visible spectral range in combination with a laser diode as a light source at a specific wavelength and a photodiode for signal detection. Within this study, the potential of the developed sensor was investigated. The corrosion process was simulated by implementing a corroded iron bar inside the measuring cell. When corrosion starts, iron ions are released leading to a complexation reaction with the dye. The results showed the potential use of the developed sensor system enabling implementation for online and on-site detection and monitoring of components susceptible to corrosion.
Dervis Türkmen; Achim Krug; Boris Mizaikoff. Monitoring Corrosion Processes via Visible Fiber-Optic Evanescent Wave Sensor. Chemosensors 2020, 8, 76 .
AMA StyleDervis Türkmen, Achim Krug, Boris Mizaikoff. Monitoring Corrosion Processes via Visible Fiber-Optic Evanescent Wave Sensor. Chemosensors. 2020; 8 (3):76.
Chicago/Turabian StyleDervis Türkmen; Achim Krug; Boris Mizaikoff. 2020. "Monitoring Corrosion Processes via Visible Fiber-Optic Evanescent Wave Sensor." Chemosensors 8, no. 3: 76.
Volatile organic compounds (VOCs) are one of the most commonly detected contaminants in water. The occurrence is mainly in gasoline and other petroleum-based products, fumigants, paints and plastics. Releases into the environment and the widespread use have an impact on the ecosystem such as humans and animals due to their toxicity, mutagenicity, and carcinogenicity. VOCs may persist in groundwater and may enter drinking water supplies. In this paper, a diamond-like carbon (DLC)-coated silicon waveguide in combination with a polymer film (ethylene/propylene copolymer, E/P-co) for enrichment of analytes was investigated to determine its suitability for ATR-FTIR (attenuated total reflection Fourier transform infrared) spectroscopic detection of VOCs. The DLC film was fluorine-terminated enhancing the adhesion of the hydrophobic polymer to the waveguide surface. The analytes diffuse into the hydrophobic polymer whereas water is excluded from the emanating evanescent field. Therefore, direct detection in aqueous systems is enabled. Nine VOCs, i.e., ethylbenzene (EB), trichloroethylene (TCE), tetrachloroethylene (TeCE), the xylene isomers (p-xylene, pXYL; m-xylene, mXYL; o-xylene, oXYL), naphthalene (NAPH), toluene (TOL), and benzene (BENZ), were evaluated simultaneously qualitatively and quantitatively showing the potential of DLC coatings revealing high sensitivities in the low ppb to ppm concentration range, i.e., 50 ppb for TeCE. To the best of our knowledge, this is the first time of IR spectroscopic detection of VOCs in aqueous solutions using DLC-coated waveguides in combination with a hydrophobic polymer. By utilizing a DLC-coated waveguide, a versatile sensor for real-time monitoring in harsh environments such as effluents, leaking pipelines, and underground storage tanks is feasible due to response times within a few minutes.
Carina Dettenrieder; Dervis Türkmen; Andreas Mattsson; Lars Österlund; Mikael Karlsson; Boris Mizaikoff. Determination of Volatile Organic Compounds in Water by Attenuated Total Reflection Infrared Spectroscopy and Diamond-Like Carbon Coated Silicon Wafers. Chemosensors 2020, 8, 75 .
AMA StyleCarina Dettenrieder, Dervis Türkmen, Andreas Mattsson, Lars Österlund, Mikael Karlsson, Boris Mizaikoff. Determination of Volatile Organic Compounds in Water by Attenuated Total Reflection Infrared Spectroscopy and Diamond-Like Carbon Coated Silicon Wafers. Chemosensors. 2020; 8 (3):75.
Chicago/Turabian StyleCarina Dettenrieder; Dervis Türkmen; Andreas Mattsson; Lars Österlund; Mikael Karlsson; Boris Mizaikoff. 2020. "Determination of Volatile Organic Compounds in Water by Attenuated Total Reflection Infrared Spectroscopy and Diamond-Like Carbon Coated Silicon Wafers." Chemosensors 8, no. 3: 75.