Medical article медицинская статья

The aim of this work was to study the influence of components of dental status on the local immunity of the oral cavity; we compared the results of the study of patients with squamous cell carcinoma (SCC) of the oral mucosa and patients without neoplasm. The study involved 136 patients with squamous cell carcinoma of the oral mucosa and 57 patients without neoplasms. In the role of the constituent characteristics of dental status were examined: the use of removable and fixed dentures, dental caries, dental plaque, sharp edges of fullings. Matrix metalloproteinases (MMPs) 2, 8 and 9, as well as their tissue inhibitors 1 and 2 were assessed in oral fluid. The results suggest the influence of all factors on local immune status of the oral cavity as proved by the significant changes in MMPs level. The use of removable dentures resulted in the pronounced decrease of MMPs and should be considered in oral SSC screening and non-invasive diagnostics.

The morbidity and mortality rates due to malignant neoplasms demonstrate annual growth, while the age of newly diagnosed patients continues to decrease. The peak incidence of malignant neoplasms in the maxillofacial region is recorded among elderly people. The development of this pathology should be attributed not only to age-related changes in the body of patients but also to harmful addictions. A comprehensive approach to solving the problem includes surveying this age group of patients to identify risk factors for the development of oncologic pathology in the maxillofacial region.