Ziwei Liu

Dr. Ziwei Liu


Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 November 2026 in Gels
Verified
Journal Article
Open access
PDF file
ZLZhang Linxiaoran
Zhang Linxiaoran
SCShengxiang Chen
Shengxiang Chen
HLHengxiang Liu
Hengxiang Liu
ZCZishuai Chen
Zishuai Chen
ZLZiwei Liu
Ziwei Liu
HHHai He
Hai He
Ablative and non-ablative energy-based procedures—lasers, intense pulsed light, radiofrequency and ultrasound—rejuvenate skin by inflicting controlled, mechanism-specific injury, yet the resulting perturbation can drive erythema, barrier disruption, dyschromia and, occasionally, scarring. Hydrogel dressings are increasingly used to manage this recovery window, but design principles specific to the post-procedure microenvironment remain scattered. This narrative review synthesises how each energy modality perturbs the cutaneous microenvironment across five coupled dimensions—thermal load, barrier integrity, inflammation, pigmentation and a merged microbiome–oxidative axis—and maps six hydrogel design strategies onto these perturbations: cooling and moist barrier restoration, antioxidant and bioactive gas delivery, immunomodulation, antibacterial and photothermal design, anti-pigmentation strategies, and active delivery against aberrant remodeling. We then grade the evidence with an author-defined, scenario-adapted rubric, revealing a steep evidence cliff: 133 unique cited source records were reconciled, of which 85 original studies were graded; only three randomized trials tested gel-based formulations directly after energy-based procedures (two tested water-swollen hydrogels under the strict definition; the cliff conclusion is unchanged), and 41 of these 85 graded original studies remain at the in vitro or small-animal stage. The other 48 records comprise 34 reviews and 14 context, methods, regulatory, or out-of-scope records, each with an explicit reason for non-grading. The article uses a structured citation-level evidence audit and is not a systematic or scoping review. Evidence from burns, chronic wounds, injectable fillers, melasma, ex vivo skin, or infected animal wounds is treated as indirect and is not used to infer efficacy after aesthetic energy-based procedures. Finally, we dissect translational bottlenecks—regulatory classification and the resulting scissors gap between laboratory innovation and registration feasibility, the sterilization paradox, and manufacturing scale-up—and propose a staged roadmap from bench to clinic. Hydrogels are poised to become precision recovery platforms rather than passive dressings, provided that design, evidence and regulation advance together. Personalized, closed-loop and bioactive-cargo dressings remain research directions for prospective, adequately controlled, procedure-specific evaluation rather than established clinical capabilities.