Cancer is a serious public health problem worldwide. This clinical pathology is associated with the activation/release of several biomolecules, including the Smyd proteins family. In this way, some studies indicate that Smyd3 is associated with cancer cells growth. It is important to mention that some drugs act as Smyd3 inhibitors in the treat some cancers. However, their interaction is very confusing; for this reason, the aim of this research was to evaluate the theoretical interaction of benzenesulfonamide and their derivatives (compounds 2 to 28) using 7o2c protein, novobiocin, BAY-6035, EPZ031686 and BCI-121 drugs as theoretical tools in DockingServer program. The results showed differences in the aminoacid residues involved in the interaction of benzenesulfonamide and their derivatives with 7o2c protein surface compared with novobiocin, BAY-6035, EPZ031686 and BCI-121 drugs. In additions, the inhibition constant (Ki) for benzenesulfonamide derivatives 2, 7, 8, 13, 14, 17, 20, 21, 24 and 28 was very lower compared to benzenesulfonamide, novobiocin, BAY-6035, EPZ031686 and BCI-121. In conclusion, the benzenesulfonamide derivatives 2, 7, 8, 13, 14, 17, 20, 21, 24 and 28 could be a good alternative as Smyd3 inhibitors to decrease cancer cells growth.

Several genetic expressions have been involved in the development of cancer such as the expression of a ribosomal kinase S6 P90 (RSK-4). It is important to mention that some compounds such as LJH685, 2073047-06-8, and SL0101 can act as RSK-4 inhibitors; however, its interaction with the surface of RSK-4 is very confusing. The aim of this research was to evaluate the interaction of twenty-nine steroid derivatives (1 to 29) with of RSK-4 surface using 6rv2 protein, LJH685, 2073047-06-8 and SL0101 as theoretical tools in the Dockingserver program. The results showed differences in the aminoacid residues involved in the interaction of steroid derivatives with 6rv2 protein surface compared with LJH685, 2073047-06-8 and SL0101. Besides, the inhibition constant for steroid derivatives 1, 12, 14, 19 and 22 was lower compared to 2073047-06-8 drug. In conclusion, the steroid derivatives 1, 12, 14, 19 and 22 could be a good alternative as RSK-4 inhibitors to decrease cancer cells growth.

Objective: To determine the degree of security and food insecurity of university students and their homes in the period of the COVID-19 pandemic. Materials and methods: A cross-sectional, observational study was carried out with 110 university students from the faculty of nutrition in the Xalapa region of the Universidad Veracruzana (UV), through an online survey in which they reported individual information and information on their household members. The online survey was hosted on the platform of the survey system of the University Coordination of Observatories (CUO) of the UV and was applied during november 2020. Results: Due to the pandemic situation, half of the respondents reported that their food expenses decreased,this was also affected because, in this period, in 15.4% of households, between 1 and 2 household members lost their job or source of income. A prevalence of households in food safety of 82.72% was identified, 12.73% mild insecurity and 4.55% moderate insecurity; 83.6% of the households presented slight alterations in their diet; almost half (45%) maintained the same pattern of consumption of processed and ultra-processed foods. Conclusions: It is necessary to promote educational interventions in the university context that favor healthy habits of students and access to nutritious and varied products, and with this, seek better food safety. Key words: Food safety; COVID 19; Food consumption; Students.

For several years, different drugs have been used to treat heart failure, such as digoxin, captopril, spironolactone, milrinone, levosimedam, dobutamine, and others. However, some of these drugs can produce secondary effects such as arrhythmia, cough, hyperkalemia, and others. Analyzing these data, this study aimed to evaluate the interaction of some chalcone derivatives (1-17) with calcium channels using theoretical models. It is important to mention that 7pjx protein, nifedipine, amlodipine, diltiazem, and verapamil were used as theoretical tools in the DockingServer program. The results showed differences in the interaction of chalcone derivatives compared with nifedipine, amlodipine, diltiazem, and verapamil drugs. Other data indicate that the inhibition constant (Ki) for chalcone analog 1 was lower compared with nifedipine, amlodipine, verapamil, and diltiazem. Besides, other results suggest that Ki for compound 11 was lower compared with nifedipine, verapamil, and diltiazem. All these data suggest that chalcone derivatives 1 and 11 could act as calcium channel inhibitors; this phenomenon could be translated into changes in blood pressure through a decrease in calcium intracellular levels. These data suggest that chalcone derivatives 1 and 11 could be good therapeutic alternatives to treat heart failure.

Some vascular endothelial growth factor receptor-1 (VEGFR-1) inhibitors drugs have been used to cancer cells; however, their interaction with VEGFR-1 is very confusing. The objective of this research was to evaluate the possible interaction of eight steroid derivatives with VEGFR-1 surface using 3hgn protein, cabozantinib, pazopanib, regorafenib, and sorafenib as theoretical tools in DockingServer program. The results showed some differences in the interaction of the steroid derivatives (1-8) with the 3hng protein surface such as i) differences in the number of amino acids; ii) different position of some amino acids compared to cabozantinib, pazopanib, regorafenib, and sorafenib. Besides, the inhibition constant (Ki) for steroid derivatives 1, 3, 6 and 8 was lower compared to cabozantinib and sorafenib drugs. In addition, other data display that Ki for steroid analogs 1, 3, 4, 6, 7 and 8 was lower compared with pazopanib and regorafenib. In conclusion, all these data suggest that steroid derivatives 1, 3, 4, 6, 7 and 8 could act as VEGFR-1 inhibitors and this phenomenon could be translated as good compounds to treat cancer cells.