Dissolving hyaluronic acid (HA) microneedles (MNs) offer a promising platform for transdermal drug delivery, yet conventional micromolding processes struggle with void‐free fabrication, large‐area scalability, and residual substrates that reduce patch flexibility on contoured skin. To overcome these limitations, we propose a screen‐printing‐based fabrication process to produce substrate‐free and scalable HA MN arrays. To improve mold filling capabilities and support the formation of solid, void‐free MNs, a hybrid HA ink blending low and high molecular weight HA was utilized. A vacuum‐assisted jig was employed to facilitate the rapid and uniform infiltration of the viscous ink into the cavities of polydimethylsiloxane (PDMS) molds. Furthermore, a “delayed drying system” utilizing a stepwise steam flow was applied to manage the evaporation rate, effectively preventing premature drying and ensuring the formation of void‐free, solid MNs. Notably, the proposed process achieved a production yield of approximately 95% for 21 × 21 arrays. The fabricated MNs exhibited structural uniformity and mechanical stability, demonstrating skin penetration and drug delivery in ex vivo porcine skin models. Multi‐drug loaded and patterned arrays were also successfully fabricated using various mask designs, confirming process versatility. This work presents a scalable and flexible manufacturing strategy for transdermal drug delivery systems.

Generating rapid, high‐power mechanical impulses with light‐driven soft actuators remains challenging because photochemical deformation alone typically provides limited force and output power. Here, we report a magnetically assisted photoresponsive azobenzene‐containing liquid crystal elastomer actuator that converts light‐induced contraction into an amplified snap‐through impulse. By programming the liquid crystal alignment, a twisted nematic architecture with orthogonal surface directors was identified to maximize through‐thickness strain mismatch and the bending moment required for snap‐through. The optimized azobenzene‐containing LCE arch exhibited a peak velocity of 140 mm s ^{− 1} under purely light‐driven operation, confirming efficient photomechanical energy conversion; however, this response was insufficient for reliable microneedle penetration. Introducing magnetic bias lowered the instability threshold and amplified elastic energy release, increasing the peak velocity to 332 mm s ^{− 1} and yielding output powers approximately two orders of magnitude higher than previously reported liquid crystal‐based soft actuators. Leveraging this capability, SU‐8 microneedles were integrated onto the actuator to create a remotely triggered injection platform capable of penetrating skin‐mimicking gelatin phantoms and ex vivo porcine skin. These results establish a general strategy for high‐power soft actuation and non‐contact microneedle‐based physical intervention.