Covalent inhibitor-based PROTACs were successfully developed for the degradation of target proteins in live cells to further extend the application scope of PROTACs.

The Bruton’s tyrosine kinase inhibitor ibrutinib exerts immunomodulatory effects through regulation of tumor-infiltrating macrophages

Polystyrene–polyamidoamine-supported gold nanoparticles were prepared using a reductant-directed formation strategy. The resulting catalysts exhibited excellent activities in the aerobic oxidation of benzyl alcohols and the homocoupling of phenylboronic acids under mild conditions and can be recycled at least 14 times without significant loss of activity.