Cara Moore

Mrs. Cara Moore


Research Focus & Metrics

Academic Career Length

1Year (2026-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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3 November 2026 in Preprints.org
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JWJoshua Winograd
Joshua Winograd
MGMichael Greenberg
Michael Greenberg
AKAutumn Kim
Autumn Kim
CMCara Moore
Cara Moore
RYRoanne Yehia
Roanne Yehia
TCTony Chen
Tony Chen
Poly(vinyl alcohol) (PVA) hydrogels are promising for meniscal replacement, but reproducing native meniscal anisotropy remains unsolved. We developed a fabrication strategy for imparting controlled anisotropy to PVA hydrogels. We hypothesized that modulus and alignment would increase with applied strain, and that circumferential strain would produce direction-dependence in a meniscal-like geometry. Dogbone specimens at three PVA concentrations were strained 0–200% during freeze–thaw processing. Meniscal-like specimens were fabricated at 27.5% PVA under 200% circumferential strain. Constructs were characterized by tensile testing, stress-relaxation compression, and polarized light microscopy. In dogbone specimens, tensile modulus rose exponentially and coherency linearly with applied strain (adjusted R² > 0.92; R² ≥ 0.96). In meniscal-like specimens, stretching increased circumferential peak stress (587 ± 173 vs 439 ± 96 kPa), and direction-dependence appeared only after stretching. Stretched constructs showed higher optical coherency (p = 0.002, r = 0.77), concentrated in the outer third of the cross-section. Compressive moduli trended lower in stretched constructs, reaching significance anteriorly. Strain applied during freeze–thaw processing programs direction-dependent stiffness and alignment into a homogeneous hydrogel, though absolute stiffness remains below native tissue. More strain during processing is the most direct route to a stiffer construct, and further development is required before functional replacement.