The aim of this study was to evaluate maternal serological status and fetal sonographic findings of Cytomegalovirus (CMV) infection. This is a retrospective study performed at Perinatology Department of Istanbul Başakşehir Çam and Sakura City Hospital. A computerized search was conducted to identify cases who underwent prenatal diagnosis of fetal CMV infection between September 2020 and December 2023. We identified nine cases with fetal CMV infection. The clinical data of the patients, gestational age at the time of diagnosis, serological, sonographic findings, and pregnancy outcomes were analyzed. A computer search of the database was made for the seroprevalance of CMV-IgM and CMV-IgG in our population. The CMV-IgM and IgG results of the 1235 patients who underwent CMV screening in the first trimester between September 2020 and December 2023 were evaluated. Fetal CMV infection was identified in nine patients. None of the 9 cases showed maternal CMV-IgM positivity. Seven of the 9 patients showed high IgG avidity index. Pregnant population had 98 % positivity for CMV-IgG. The evaluation of serologic tests for CMV is not straightforward in the second and third trimester. IgM and IgG avidity should be interpreted with caution in the second and third trimester. In the presence of ultrasound findings suggesting fetal CMV infection and CMV-IgG positivity, invasive diagnostic tests rather than serological test should be discussed with the patient, and non-primary infections should always be considered to minimize overlooked fetal cytomegalovirus infections and missed antiviral treatment opportunity.

Aims: To compare serum levels of sC5b-9, C3, C4, C1-INH, and CH50, which are indicators of complement system activation and regulatory processes, in pregnant women with and without fetal growth restriction (FGR). Methods: This study enrolled eighty-six women with gestational age between 24 and 36 weeks. Maternal blood samples were obtained from 43 patients diagnosed with FGR and 43 from healthy pregnancies. Serum complement levels were measured using commercially available ELISA kits according to the manufacturer’s instructions (SunRed, China). Results: When the levels of complement activation biomarkers of pregnancies with FGR were compared with those of healthy pregnancies, the C1est level was significantly higher, C4 and CH50 levels were slightly lower, and Sc5b9 and C3 levels were similar. Conclusion: While the exact role of complement activation in FGR remains fully elucidated, the elevated levels of C1-INH in women with FGR suggest a compensatory mechanism to mitigate thrombus formation and inflammation. This adaptive response may be a potential therapeutic target for improving placental function and pregnancy outcomes.

Objective COVID-19 has spread all over the world since December 2019. There is little evidence concerning maternal or perinatal outcomes up to now. The present study aimed to compare pregnant women with severe and mild-moderate COVID-19 symptoms in terms of maternal and perinatal outcomes. Methods The study group was composed of pregnant patients admitted to our tertiary center with symptoms and diagnosed with severe acute respiratory syndrome Coronavirus 2 (SARS-Cov-2). The patients were categorized into two groups: severe and not severe, and women determined as in the severe disease group were hospitalized. The patients were continued to their routine follow-up, their maternal and perinatal outcomes were recorded. Results A total of 52 patients were enrolled in the study: 59.6% presented mild-moderate disease and 40.4% presented severe disease. The gestational age at diagnosis of COVID-19 was higher in the patients with severe symptoms than in patients with mild-moderate symptoms (median 20.5 vs 28.0, respectively, p=0.048). There was no difference between those two groups in terms of maternal and perinatal outcomes. Conclusion Despite the growing number of published studies on COVID-19 in pregnancy, there are insufficient quality data to draw conclusions about the severity of COVID-19 in symptomatic pregnant women and its maternal and neonatal consequences. In our study, there is no difference between mild-moderate and severe groups in terms of maternal and perinatal outcomes.

Amniocentesis is the most commonly used invasive prenatal diagnostic test. This study aimed to investigate the effect of video-based multimedia information (MMI) on the anxiety and pain levels of patients undergoing amniocentesis. This randomized controlled study included all consecutive women aged 18–45 years scheduled for amniocentesis. Subjects were assigned to receive video-based MMI or standard written information. Anxiety levels were assessed pre-procedure and post-procedure using the State and Trait Anxiety Inventory-State (STAI-S). All patients underwent standard amniocentesis by the same perinatologists. After amniocentesis, Likert scale was used to evaluate the ease of the procedure and patient satisfaction, and a visual analog scale was used to evaluate pain. Pregnancy results and amniocentesis results were noted. Eighty-four patients were randomized to receive video-based MMI, and 76 were randomized to receive written information. The post-procedure STAI-S score was significantly lower in both the video group and the control group compared to the pre-procedure STAI-S score (47.8 ± 5.23 vs. 45.86 ± 5.02, 95% CI: [2.38–1.52], p < 0.001, and 46.75 ± 7.35 vs. 44.82 ± 6.85, 95% CI: [2.33–1.51], p < 0.001). The satisfaction rate of the video group was significantly higher than controls (69.05% vs. 48.68%, p = 0.01). Procedure pain, ease of procedure, and pregnancy outcomes were similar for both groups (p > 0.05). Performing video-based MMI before the amniocentesis procedure is associated with higher patient satisfaction than standard written information. Video-based MMI was not associated with reductions in pain and anxiety in patients undergoing amniocentesis.

Anne ölümü, gebeliğin başlangıcından doğum sonrası 42. günü kapsayacak şekilde; kaza ve tesadüfi sebeplerden kaynaklanmayan, gebelik veya gebeliğin yönetiminden kaynaklı olarak veya gebeliğin ağırlaştırdığı herhangi bir sebeple kadının ölmesi olarak ifade edilmektedir. Ülkemizde her yıl yaklaşık 1.5 milyon bayan gebe kalıyor, bunun 1 milyon 350 bin i doğumla sonuçlanıyor. Anne ölümoranı 2017 TÜİK verilerine göre 100 binde 14.4 dir.

Epithelial-mesenchymal transition and chemokine signaling are implicated in endometrial carcinogenesis, yet the value of their circulating mediators as pre