One of the most significant challenges implementing colloidal magnetic nanoparticles in medicine is the efficient heating of microliter quantities by applying a low frequency alternating magnetic field. The ultimate goal is to accomplish nonsurgically the treatment of millimeter size tumors. Here, we demonstrate the synthesis, characterization, and the in vitro as well as in vivo efficiency of a dextran coated maghemite $\left(\gamma {\text{-Fe}}_2{\text{O}}_3\right)$ ferrofluid with an exceptional response to magnetic heating. The difference to previous synthetic attempts is the high charge of the dextran coating, which according to our study maintains the colloidal stability and good dispersion of the ferrofluid during the magnetic heating stage. Specifically, in vitro $2\mu \text{l}$ of the ferrofluid gives an outstanding temperature rise of $33°\text{C}$ within 10 min, while in vivo treatment, by infusing $150\mu \text{l}$ of the ferrofluid in animal model (rat) glioma tumors, causes an impressive cancer tissue dissolution.

Studying the properties of water confined in carbon nanotubes (CNTs) have gained a lot of interest in recent years due to the vast potential applications of systems in nanoscale liquid transport as well as biology functions. This article presents a comprehensive review of recent experimental and theoretical results using nuclear magnetic resonance (NMR) and molecular dynamics (MD) simulations. Different NMR methods including